Title:
ANALGESIC METHODS USING ENDOTHELIN RECEPTOR LIGANDS
Document Type and Number:
WIPO Patent Application WO2003009805
Kind Code:
A3
Abstract:
The present invention features methods and compositions for preventing, reducing or eliminating pain (for example, acute pain) using an endothelin-B receptor agonist alone or in combination with either an endothelin-A receptor antagonist, an opioid receptor agonist, a GIRK channel activator, or a PKC activator.
Inventors:
DAVAR GUDARZ
STRICHARTZ GARY
FAREED MOIN
KHODOROVA ALLA
STRICHARTZ GARY
FAREED MOIN
KHODOROVA ALLA
Application Number:
PCT/US2002/023257
Publication Date:
May 08, 2003
Filing Date:
July 23, 2002
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
International Classes:
A61K31/00; A61K31/42; A61P9/10; A61P29/00; A61P35/00; (IPC1-7): A61K38/10; A61K38/16
Foreign References:
| US5658943A | 1997-08-19 |
Other References:
PALACIOS ET AL.: "Endothelin ETB receptors counteract venoconstrictor effects of endothelin-1 in anesthetized rats", LIFE SCIENCES, vol. 63, no. 14, 1998, pages 1239 - 1249, XP002961264
PIOVEZAN ET AL.: "Effects of endothelin-1 on capsaicin-induced nociception in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 351, 1998, pages 15 - 22, XP002961265
PIOVEZAN ET AL.: "Effects of endothelin-1 on capsaicin-induced nociception in mice", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 351, 1998, pages 15 - 22, XP002961265
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