Title:
ANALOGS OF ISOVALERAMIDE, A PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND A METHOD OF TREATING CENTRAL NERVOUS SYSTEM CONDITIONS OR DISEASES
Document Type and Number:
WIPO Patent Application WO2006012603
Kind Code:
A3
Abstract:
An isovaleramide analog having at least one of an increased potency, an increased half-life, and an increased stability compared to isovaleramide. The isovaleramide analog is a cyclic analog or a noncyclic analog. The isovaleramide analog is formulated into a pharmaceutical composition. A method of treating a central nervous system condition or disease is also disclosed. The method comprises administering an isovaleramide analog to a patient suffering from the central nervous system condition or disease.
Inventors:
ARTMAN LINDA D (US)
BALANDRIN MANUEL F (US)
MOE SCOTT T (US)
VAN WAGENEN BRADFORD C (US)
PESYAN AMIR (US)
BALANDRIN MANUEL F (US)
MOE SCOTT T (US)
VAN WAGENEN BRADFORD C (US)
PESYAN AMIR (US)
Application Number:
PCT/US2005/026279
Publication Date:
June 01, 2006
Filing Date:
July 22, 2005
Export Citation:
Assignee:
NPS PHARMA INC (US)
ARTMAN LINDA D (US)
BALANDRIN MANUEL F (US)
MOE SCOTT T (US)
VAN WAGENEN BRADFORD C (US)
PESYAN AMIR (US)
ARTMAN LINDA D (US)
BALANDRIN MANUEL F (US)
MOE SCOTT T (US)
VAN WAGENEN BRADFORD C (US)
PESYAN AMIR (US)
International Classes:
A61K31/16; A61K31/10; A61K31/19; A61P25/08; C07C53/126; C07C233/05; C07C233/08; C07C233/58; C07C237/06; C07C237/14; C07C317/04
Domestic Patent References:
| WO2001028516A2 | 2001-04-26 | |||
| WO2000051586A2 | 2000-09-08 | |||
| WO2004037769A2 | 2004-05-06 | |||
| WO1998008498A1 | 1998-03-05 | |||
| WO2002074727A1 | 2002-09-26 | |||
| WO1999031057A1 | 1999-06-24 | |||
| WO1999031074A2 | 1999-06-24 |
Foreign References:
| EP0042626A2 | 1981-12-30 | |||
| US4256126A | 1981-03-17 |
Other References:
HAJ-YEHIA A ET AL: "STRUCTURE-PHARMACOKINETIC RELATIONSHIPS IN A SERIES OF SHORT FATTY ACID AMIDES THAT POSSESS ANTICONVULSANT ACTIVITY", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 79, no. 8, August 1990 (1990-08-01), pages 719 - 724, XP001037138, ISSN: 0022-3549
TSAI L ET AL: "STERIC EFFECTS IN HYDROLYSIS OF HINDERED AMIDES AND NITRILES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 79, 20 May 1957 (1957-05-20), pages 2530 - 2533, XP000943821, ISSN: 0002-7863
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FARINA, MARIO ET AL: "Optical antipodes of 2,3,3-trimethyl-1-butanol and 2,3,3-trimethylbutyric acid", XP002362585, retrieved from STN Database accession no. 1966:465111
TSAI L ET AL: "STERIC EFFECTS IN HYDROLYSIS OF HINDERED AMIDES AND NITRILES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 79, 20 May 1957 (1957-05-20), pages 2530 - 2533, XP000943821, ISSN: 0002-7863
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; FARINA, MARIO ET AL: "Optical antipodes of 2,3,3-trimethyl-1-butanol and 2,3,3-trimethylbutyric acid", XP002362585, retrieved from STN Database accession no. 1966:465111
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