Title:
ANALYSIS APPARATUS HAVING PLURALITY OF LIQUID CHROMATOGRAPHS, AND ANALYSIS METHOD FOR SAME
Document Type and Number:
WIPO Patent Application WO/2020/105624
Kind Code:
A1
Abstract:
This analysis apparatus has a plurality of liquid chromatographs whereby separation performance, etc., is determined at an appropriate timing and analysis performance can be enhanced in an early stage. Analysis is started, a non-retained component is added to a sample to be measured to prepare a mixed sample, and the mixed sample is introduced to an analysis flow channel (S401-S404). The mixed sample is separated into components by a separation column, chromatogram data are outputted by a detector, and analysis is ended (S404-S406). A retention time and peak information are acquired from the chromatogram outputted from the detector, a determination is made as to whether the measurement result is within an allowed range, and a transition is made to the next analysis when the measurement result is within the allowed range (S407-S409). When the separation performance is outside the allowed range in step S408, the amount of shift in the transit time t0 of the non-retained component from an allowed value is confirmed, and an instruction to replace the separation column outputted to an output unit when the amount of fluctuation of the transit time t0 is within an allowed range (S410, S411). When the amount of fluctuation is outside the allowed range in step S410, an instruction to perform maintenance of the apparatus is outputted to the output unit (S412).
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Inventors:
AKIEDA DAISUKE (JP)
NOGAMI MAKOTO (JP)
SUZUKI IWAO (JP)
KAWARAI MASAKO (JP)
OGATA IZUMI (JP)
ITO SHINYA (JP)
NOGAMI MAKOTO (JP)
SUZUKI IWAO (JP)
KAWARAI MASAKO (JP)
OGATA IZUMI (JP)
ITO SHINYA (JP)
Application Number:
PCT/JP2019/045240
Publication Date:
May 28, 2020
Filing Date:
November 19, 2019
Export Citation:
Assignee:
HITACHI HIGH TECH CORP (JP)
International Classes:
G01N30/24; G01N30/46; G01N30/86
Domestic Patent References:
| WO2017216934A1 | 2017-12-21 |
Foreign References:
| JP2008224559A | 2008-09-25 | |||
| JP2017138248A | 2017-08-10 | |||
| JP2004524518A | 2004-08-12 | |||
| JP2004515770A | 2004-05-27 | |||
| JP2006084308A | 2006-03-30 | |||
| US20140033793A1 | 2014-02-06 | |||
| JP4372419B2 | 2009-11-25 | |||
| JP2017138248A | 2017-08-10 |
Other References:
HIROSHI NAKAMURA: "Question 5: What is a suitable solute to measure t0 or hold-up volume? Please tell me for each isolation mode.", LIQUID KURO TORA NO MAKI: HPLC Q & A THAT NO ONE COULD ASK, 22 November 2001 (2001-11-22), pages 8, XP009527727, ISBN: 4-924753-47-5
HIROSHI NAKAMURA: "Question 74: What kind of reagents are used for evaluation of color, and what grade of reagents should be used? Are there any reagents that are already mixed?", LIQUID CHROMATIC DOG VOLUME: HPLC Q & A THAT NO ONE COULD ASK, 10 December 2004 (2004-12-10), pages 145, XP009527729, ISBN: 4-924753-52-1
HIROSHI NAKAMURA: "Question 23: Please tell me the source of the abnormal peak shape and its countermeasures.", VOLUME OF LIQUID KURO RYU (RYU) HPLC Q & A THAT NO ONE COULD ASK, 30 November 2002 (2002-11-30), pages 42 - 43, XP009527730, ISBN: 4-924753-48-3
HIROSHI NAKAMURA: "Question 74: What kind of reagents are used for evaluation of color, and what grade of reagents should be used? Are there any reagents that are already mixed?", LIQUID CHROMATIC DOG VOLUME: HPLC Q & A THAT NO ONE COULD ASK, 10 December 2004 (2004-12-10), pages 145, XP009527729, ISBN: 4-924753-52-1
HIROSHI NAKAMURA: "Question 23: Please tell me the source of the abnormal peak shape and its countermeasures.", VOLUME OF LIQUID KURO RYU (RYU) HPLC Q & A THAT NO ONE COULD ASK, 30 November 2002 (2002-11-30), pages 42 - 43, XP009527730, ISBN: 4-924753-48-3
Attorney, Agent or Firm:
KAICHI IP (JP)
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