ANALYSIS METHOD FOR PREDICTION OF RESPONSE TO PREOPERATIVE CHEMORADIOTHERAPY IN RECTAL CANCER PATIENT

Title:

ANALYSIS METHOD FOR PREDICTION OF RESPONSE TO PREOPERATIVE CHEMORADIOTHERAPY IN RECTAL CANCER PATIENT

Document Type and Number:

WIPO Patent Application WO/2021/167280

Kind Code:

A1

Abstract:

The present invention provides an analysis method for providing information necessary for diagnosis of a patient who exhibits a response to preoperative chemoradiotherapy among rectal cancer patients. It is revealed in the present invention that when nine genes, that is, FGFR3, GNA11, H3F3A, IL12A, IL1R1, IL2RB, NKD1, SGK2, and SPRY2 genes in tumor tissues of rectal cancer patients are analyzed for expression levels in combination, a response (sensitivity) to preoperative chemoradiotherapy can be predicted with high accuracy. Therefore, a combination of the genes can be advantageously used as a biomarker capable of selecting a rectal cancer patient who exhibits a response to preoperative chemoradiotherapy.

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Inventors:

YU CHANG-SIK (KR)
PARK IN-JA (KR)
HONG SEUNG-MO (KR)
AHN SUNG-MIN (KR)
ANSARI ADNAN AHMAD (KR)
MUSTAFA BILAL (KR)
PARK JIN-YOUNG (KR)

Application Number:

PCT/KR2021/001605

Publication Date:

August 26, 2021

Filing Date:

February 08, 2021

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Assignee:

ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
CBSBIOSCIENCE CO LTD (KR)

International Classes:

C12Q1/6886

Foreign References:

KR20190079801A	2019-07-08
KR20180040420A	2018-04-20
KR20090003178A	2009-01-09

Other References:

CHO EUNHAE; PARK IN JA; YEOM SEUNG-SEOP; HONG SEUNG MO; LEE JUNG BOK; KIM YEON WOOK; KIM MI-JU; LIM HYE MIN; LIM SEOK-BYUNG; YU CH: "A Multigene Model for Predicting Tumor Responsiveness After Preoperative Chemoradiotherapy for Rectal Cancer", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS., PERGAMON PRESS., USA, vol. 105, no. 4, 13 August 2019 (2019-08-13), USA, pages 834 - 842, XP085878516, ISSN: 0360-3016, DOI: 10.1016/j.ijrobp.2019.07.058
CATERINA MILLINO, ISACCO MARETTO, BENIAMINA PACCHIONI, MAURA DIGITO, ANTONINO DE PAOLI, VINCENZO CANZONIERI, EDOARDO D’ANGELO, MAR: "Gene and MicroRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated With Preoperative Chemoradiotherapy", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 232, pages 426 - 435, XP055838509

Attorney, Agent or Firm:

OH, Kook-Jin (KR)

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