Title:
ANG-(1-7) AND DERIVATIVE OLIGOPEPTIDES FOR THE TREATMENT OF TRAUMATIC BRAIN INJURY AND OTHER COGNITIVE IMPAIRMENTS
Document Type and Number:
WIPO Patent Application WO/2018/129511
Kind Code:
A3
Abstract:
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or traumatic brain injury.
Inventors:
HAY MEREDITH (US)
POLT ROBIN L (US)
VANDERAH TODD (US)
MILNES TALLY (US)
POLT ROBIN L (US)
VANDERAH TODD (US)
MILNES TALLY (US)
Application Number:
PCT/US2018/012906
Publication Date:
September 20, 2018
Filing Date:
January 09, 2018
Export Citation:
Assignee:
UNIV ARIZONA (US)
International Classes:
C07K7/14; A61K38/08; C07K7/06
Foreign References:
| US20160016996A1 | 2016-01-21 | |||
| US8633158B1 | 2014-01-21 |
Attorney, Agent or Firm:
KUHLMANN, Anthony C. (US)
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