Title:
ANGIOTENSIS CONVERTING ENZYME INHIBITORS
Document Type and Number:
WIPO Patent Application WO1992000276
Kind Code:
A3
Abstract:
PCT No. PCT/GB91/00980 Sec. 371 Date Dec. 10, 1992 Sec. 102(e) Date Dec. 10, 1992 PCT Filed Jun. 18, 1991 PCT Pub. No. WO92/00276 PCT Pub. Date Jan. 9, 1992.Angiotensin converting enzyme inhibitors have the formula Z(CH2)nCHR1COOCHR2COOH in which Z is -SR3, -COCHR4NHCOR5, or -NHCHR7COOH, R4, R5, R6, and R7, which may be the same or different, are each phenyl or alkylphenyl C7-12, R4 is hydrogen, alkyl C1-6, NHR8 or (CH2)pR9, R2 is (CH2)mXR10, alkyl C1-6 optionally substituted by a saturated 5- or 6-membered carbocyclic or heterocyclic ring, alkylhalo C1-6, alkylcyano C1-6, or alkyl phenyl C7-12, the phenyl being optionally substituted by NO2 or NH2, X is O, S(O)q, C=O or NR11, and R10 is alkyl C1-6, alkylhalo C1-6, alkoxy C1-6, alkoxy C1-6 substituted by halogen, alkanoyl C1-6, S(O)rR12, NR13R14, phenyl, alkylphenyl C7-12, naphthalenyl or a 5-membered unsaturated heterocyclic ring, n is an integer from 0 to 6, m and p, which may be the same or different, are each an integer from 1 to 6, R9 is hydrogen, SR15 or phenyl optionally substituted by OR16, R3 and R15, which may be the same or different, are each hydrogen or alkanoyl C1-6, R8 is hydrogen or COOR17, q and r, which may be the same or different, are each 0, 1, or 2, R11, R13, R14, R16, and R17, which may be the same or different, are each hydrogen or alkyl C1-6, and R12 is hydrogen, alkyl C1-6 or phenyl. The compounds, and salts thereof, are useful as vasodilators.
Inventors:
BAXTER ANDREW JOHN GILBY (GB)
MEGHANI PREMJI (GB)
MEGHANI PREMJI (GB)
Application Number:
PCT/GB1991/000980
Publication Date:
February 20, 1992
Filing Date:
June 18, 1991
Export Citation:
Assignee:
FISONS PLC (GB)
International Classes:
A61K31/22; A61P43/00; C07C229/16; C07C229/36; A61K31/215; C07C233/47; C07C233/83; C07C317/44; C07C323/52; C07C323/56; C07D333/34; C07D339/06; C07F9/12; C07F9/40; (IPC1-7): C07C323/52; C07C311/06; C07D333/34; A61K31/19
Foreign References:
| GB2001963A | 1979-02-14 | |||
| US4242265A | 1980-12-30 |
Other References:
See also references of EP 0535042A1
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