Title:
ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO
Document Type and Number:
WIPO Patent Application WO2002046171
Kind Code:
A3
Abstract:
Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: (A) wherein R>1< and R>6< are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to IKK inhibition. Thus, methods or treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.
Inventors:
KOIS ADAM
MACFARLANE KAREN J
SATOH YOSHITAKA
BHAGWAT SHRIPAD S
PARNES JASON S
PALANKI MOORTHY S S
ERDMAN PAUL E
MACFARLANE KAREN J
SATOH YOSHITAKA
BHAGWAT SHRIPAD S
PARNES JASON S
PALANKI MOORTHY S S
ERDMAN PAUL E
Application Number:
PCT/US2001/046403
Publication Date:
January 23, 2003
Filing Date:
December 05, 2001
Export Citation:
Assignee:
SIGNAL PHARM INC (US)
International Classes:
A61K31/505; A61K31/506; A61K31/5377; A61K31/5415; A61K45/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P15/10; A61P17/02; A61P19/02; A61P19/06; A61P19/10; A61P25/00; A61P25/08; A61P25/18; A61P25/28; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D239/42; C07D401/12; C07D403/04; C07D403/08; C07D403/12; C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D409/14; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D417/14; (IPC1-7): C07D239/42; C07D401/12; C07D405/12; C07D413/12; C07D403/12; A61K31/505; A61P29/00
Domestic Patent References:
| WO1999001439A1 | 1999-01-14 | |||
| WO2002046170A2 | 2002-06-13 |
Other References:
See also references of EP 1349841A2
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