Title:
ANIONIC POLYPEPTIDE CARBOXYLATED BIO-NANO-MAGNETIC BEAD AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/140911
Kind Code:
A1
Abstract:
An anionic polypeptide carboxylated bio-nano-magnetic bead, formed by fusion expression of an anionic polypeptide polymer linked to a membrane protein of the bio-nano-magnetic bead via a flexible linker. The amino acid residue of the flexible linker is GCVA(DLGGV)2GVC(GA)3MADEGAG, which displays a specific anionic polypeptide structure on the surface of the bio-nano-magnetic beads. The number of provided functional groups, which serve as modification sites, is large. The number of binding antibodies is also high. The magnetic beads have good biological activity, higher specificity, and good practicability.
Inventors:
ZHANG JINJU (CN)
WANG HONGGUANG (CN)
WANG HONGGUANG (CN)
Application Number:
PCT/CN2018/102326
Publication Date:
July 25, 2019
Filing Date:
August 24, 2018
Export Citation:
Assignee:
BEIJING ZHONGKEYUANRONG BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N15/10; C12N15/62; C12N15/63; H01F1/00
Domestic Patent References:
| WO2005046572A2 | 2005-05-26 |
Foreign References:
| CN108251415A | 2018-07-06 | |||
| CN106366194A | 2017-02-01 | |||
| CN107045061A | 2017-08-15 | |||
| CN102617810A | 2012-08-01 | |||
| CN104316683A | 2015-01-28 | |||
| CN107202884A | 2017-09-26 |
Other References:
CUSANO, A.M. ET AL.: "Integration of Binding Peptide Selection and Multifunctional Particles as Tool-Box for Capture of Soluble Proteins in Serum", JOURNAL OF THE ROYAL SOCIETY INTERFACE, vol. 11, no. 20140718, 6 October 2014 (2014-10-06) - 31 December 2014 (2014-12-31), pages 1 - 11, XP055625487
Attorney, Agent or Firm:
BEIJING AIPUNAJIE PATENT FIRM (CN)
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