Title:
ANNONA SQUAMOSAL SEED EXTRACT FOR TREATING CHORIOCARCINOMA, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/156331
Kind Code:
A1
Abstract:
Provided is an application of compounds of any one or more of formula I, formula II and formula III in preparation of a drug for treating choriocarcinoma, belonging to the technical field of antitumor drugs. The compounds shown in formula I, formula II and formula III are monomer ingredients in an annona squamosa total lactones extract. Also provided are a preparation method for an annona squamosal seed extract for treating choriocarcinoma and a product thereof. The compounds shown in formula I, formula II and formula III and the prepared extract (including effective parts) prepared by the preparation method have an IC 50 value of less than 10 ng/ml to choriocarcinoma JEG-3, wherein the extract has an IC 50 value as low as 1.269 mg/mL to choriocarcinoma JEG-3, and the effective parts have an IC 50 value of 0.4277 nM to choriocarcinoma JEG-3. Particularly, the compound shown in formula I achieves an IC 50 value of only 0.1302 nM to choriocarcinoma JEG-3, while the IC50 for most other tumors is often between 1 uM and 100 uM, and the difference is more than three orders of magnitude, showing a selective and efficient killing effect on choriocarcinoma JEG-3.
Inventors:
WANG XIANGTAO (CN)
AO HUI (CN)
LI HAOWEN (CN)
WANG YI-AN (CN)
GUO YIFEI (CN)
HAN MEIHUA (CN)
AO HUI (CN)
LI HAOWEN (CN)
WANG YI-AN (CN)
GUO YIFEI (CN)
HAN MEIHUA (CN)
Application Number:
PCT/CN2020/073269
Publication Date:
August 06, 2020
Filing Date:
January 20, 2020
Export Citation:
Assignee:
THE INST OF MEDICINAL PLANT DEVELOPMENT (CN)
International Classes:
A61K31/365; A61K36/185; A61P35/00; C07D307/58
Foreign References:
| CN109793732A | 2019-05-24 | |||
| CN109528785A | 2019-03-29 | |||
| CN109620822A | 2019-04-16 | |||
| CN103239491A | 2013-08-14 |
Other References:
SUN LAN : "Determination of Annonaceous Acetogenins in Annonaceae Plants by HPLC", ACTA PHARMACEUTICA SINICA, vol. 36, no. 9, 31 December 2001 (2001-12-31), pages 683 - 685, XP009522443, ISSN: 0513-4870
AHMED ABDEL-LATEFF, EL-MENSHAWI BASSEM S, HAGGAG MOHAMED Y, NAWWAR MAHMOUD A: "Cytotoxic Acetogenins from Annona Glabra Cultivated in Egypt", PHARMACOGNOSY RESEARCH, vol. 1, no. 3, 30 June 2009 (2009-06-30), pages 135 - 135, XP055724280
AHMED ABDEL-LATEFF, EL-MENSHAWI BASSEM S, HAGGAG MOHAMED Y, NAWWAR MAHMOUD A: "Cytotoxic Acetogenins from Annona Glabra Cultivated in Egypt", PHARMACOGNOSY RESEARCH, vol. 1, no. 3, 30 June 2009 (2009-06-30), pages 135 - 135, XP055724280
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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