Title:
ANNULATED PYRIDAZINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/003002
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a pharmaceutical composition, in particular, a compound suitable for preventing and/or treating inflammatory diseases and/or neurodegenerative diseases. The inventors of the present invention conducted extensive studies to find a compound that has an inhibiting action on NLRP3 inflammasome activation, and found that an annulated pyridazine compound has an inhibiting action on NLRP3 inflammasome activation, leading to the achievement of the present invention. The annulated pyridazine compound according to the present invention is expected to serve as a drug for preventing and/or treating inflammatory diseases and/or a neurodegenerative diseases.
Inventors:
INAGAKI YUSUKE (JP)
WASHIO TAKUYA (JP)
KOIZUMI YUKA (JP)
TOYA HIROKI (JP)
YAMASHITA YUMI (JP)
KURIWAKI IKUMI (JP)
MAEDA JUNKO (JP)
KOIKE TAKANORI (JP)
KAMIKUBO TAKASHI (JP)
YAMAKI SUSUMU (JP)
KURAMOTO KAZUYUKI (JP)
SABA KENGO (JP)
TOMIYAMA HIROSHI (JP)
IWAI YOSHINORI (JP)
NAKAMURA AKIHIKO (JP)
WASHIO TAKUYA (JP)
KOIZUMI YUKA (JP)
TOYA HIROKI (JP)
YAMASHITA YUMI (JP)
KURIWAKI IKUMI (JP)
MAEDA JUNKO (JP)
KOIKE TAKANORI (JP)
KAMIKUBO TAKASHI (JP)
YAMAKI SUSUMU (JP)
KURAMOTO KAZUYUKI (JP)
SABA KENGO (JP)
TOMIYAMA HIROSHI (JP)
IWAI YOSHINORI (JP)
NAKAMURA AKIHIKO (JP)
Application Number:
PCT/JP2022/028138
Publication Date:
January 26, 2023
Filing Date:
July 20, 2022
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D237/32; A61K31/502; A61K31/5025; A61K31/504; A61P25/00; A61P25/28; A61P29/00; A61P37/02; C07D237/26; C07D237/34; C07D401/12; C07D403/12; C07D405/12; C07D405/14; C07D409/12; C07D471/04; C07D487/04; C07D491/044; C07D491/052; C07D491/107; C07D495/04
Domestic Patent References:
| WO2020234715A1 | 2020-11-26 | |||
| WO2007130383A2 | 2007-11-15 | |||
| WO2022135567A1 | 2022-06-30 | |||
| WO2020234715A1 | 2020-11-26 | |||
| WO2021193897A1 | 2021-09-30 | |||
| WO2019008025A1 | 2019-01-10 | |||
| WO2017184604A1 | 2017-10-26 | |||
| WO2018015445A1 | 2018-01-25 | |||
| WO2006004589A2 | 2006-01-12 | |||
| WO2014191737A1 | 2014-12-04 | |||
| WO2015001348A1 | 2015-01-08 | |||
| WO2021067696A1 | 2021-04-08 |
Foreign References:
| US11319319B1 | 2022-05-03 | |||
| US11319319B1 | 2022-05-03 |
Other References:
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SCIENCE TRANSLATIONAL MEDICINE, vol. 10, 2018
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"Pharmaceutical Research and Development", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "lyakuhin no Kaihatsu"
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 2005, pages 4685 - 4696
CHEMICAL REVIEWS, vol. 107, 2007, pages 874 - 922
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol. 12, no. 1, 2009, pages 78 - 95
ARTHRITIS RESEARCH AND THERAPY, vol. 12, no. 2, 2010, pages 206
JOURNAL OF MOLECULAR MEDICINE, vol. 92, no. 10, 2014, pages 1069 - 1082
GUT, vol. 59, no. 9, 2010, pages 1192 - 1100
NATURE, vol. 493, no. 7434, 2013, pages 674 - 678
PLOS ONE, vol. 8, no. 1, 2013
INFLAMMATION, vol. 41, no. 1, 2018, pages 93 - 103
JOURNAL OF NEUROPATHOLOGY AND EXPRIMENTAL NEUROLOGY, vol. 77, no. 11, 2018, pages 1055 - 1065
SCIENCE TRANSLATIONAL MEDICINE, vol. 10, 2018
PROG. MED., vol. 5, 1985, pages 2157 - 2161
"Pharmaceutical Research and Development", vol. 7, 1990, HIROKAWA PUBLISHING COMPANY, article "lyakuhin no Kaihatsu"
"Bunshi Sekkei", MOLECULAR DESIGN, pages 163 - 198
"International Journal of Radiation Applications and Instrumentation. Part A", APPLIED RADIATION AND ISOTOPES, vol. 39, no. 4, 1988, pages 287 - 290
WUTSGREENE: "Greene's Protective Groups in Organic Synthesis", 2006
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 2005, pages 4685 - 4696
CHEMICAL REVIEWS, vol. 107, 2007, pages 874 - 922
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, vol. 12, no. 1, 2009, pages 78 - 95
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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