Title:
RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE
Document Type and Number:
WIPO Patent Application WO/2020/011147
Kind Code:
A1
Abstract:
Provided herein are compounds as RORγ antagonist having Formula (I). The compounds or pharmaceutical composition thereof can be used for regulating Retinoid-related orphan receptor gamma t (RORγt). Also provided herein are methods of preparation of the compounds and composition thereof, and uses thereof in treating or preventing RORγt mediated inflammation or autoimmune diseases in mammals, particularly humans.
Inventors:
LIU BING (CN)
ZHONG XUE (CN)
WANG FENG (CN)
LI XUKE (CN)
HE WEI (CN)
PAN WEI (CN)
HUANG JIUZHONG (CN)
ZHANG YINGJUN (CN)
ZHENG CHANGCHUN (CN)
ZHONG XUE (CN)
WANG FENG (CN)
LI XUKE (CN)
HE WEI (CN)
PAN WEI (CN)
HUANG JIUZHONG (CN)
ZHANG YINGJUN (CN)
ZHENG CHANGCHUN (CN)
Application Number:
PCT/CN2019/095203
Publication Date:
January 16, 2020
Filing Date:
July 09, 2019
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
A61K31/5375; C07D295/155; A61K31/5377; A61P19/02; C07D413/04; C07D417/04
Domestic Patent References:
| WO2018116285A1 | 2018-06-28 | |||
| WO2017157332A1 | 2017-09-21 | |||
| WO2017024018A1 | 2017-02-09 |
Foreign References:
| CN106061947A | 2016-10-26 |
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