Title:
ANTHRANILIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1995/018097
Kind Code:
A1
Abstract:
An anthranilic acid derivative having a cGMP-PDE inhibitory activity and represented by general formula (I), or a pharmacologically acceptable salt thereof wherein R1, R2, R3 and R4 represent each independently hydrogen, halogen, hydroxy, optionally halogenated lower alkyl, optionally halogenated lower alkoxy, nitro, hydroxyalkyl, cyano, etc.; R5 and R6 represent each independently hydrogen, halogen hydroxy, cyano, optionally halogenated lower alkyl, optionally halogenated lower alkoxy, etc.; W represents -N= or -CH=; R7 and R8 represent each independently hydrogen, optionally halogenated lower alkyl, etc.; A represents hydrogen, optionally halogenated lower alkyl, etc.; Z represents hydroxy, optionally halogenated lower alkoxy, cyano, halogen, etc.; Y represents oxygen or sulfur; and n represents an integer of 0, 1 to 6.
Inventors:
OZAKI FUMIHIRO (JP)
ISHIBASHI KEIJI (JP)
IKUTA HIRONORI (JP)
ISHIHARA HIROKI (JP)
SOUDA SHIGERU (JP)
ISHIBASHI KEIJI (JP)
IKUTA HIRONORI (JP)
ISHIHARA HIROKI (JP)
SOUDA SHIGERU (JP)
Application Number:
PCT/JP1994/002262
Publication Date:
July 06, 1995
Filing Date:
December 27, 1994
Export Citation:
Assignee:
EISAI CO LTD (JP)
OZAKI FUMIHIRO (JP)
ISHIBASHI KEIJI (JP)
IKUTA HIRONORI (JP)
ISHIHARA HIROKI (JP)
SOUDA SHIGERU (JP)
OZAKI FUMIHIRO (JP)
ISHIBASHI KEIJI (JP)
IKUTA HIRONORI (JP)
ISHIHARA HIROKI (JP)
SOUDA SHIGERU (JP)
International Classes:
A61K31/24; A61K31/41; A61K31/415; A61K31/452; A61P3/00; C07C217/58; C07C229/56; C07C229/64; C07C237/30; C07C237/32; C07C237/40; C07C237/42; C07C237/44; C07C255/57; C07C255/58; C07C255/59; C07C255/60; C07C311/39; C07C311/40; C07C311/51; C07D211/46; C07D211/62; C07D213/40; C07D213/64; C07D213/81; C07D265/26; C07D295/15; C07D295/155; C07D307/33; C07D317/48; C07D317/58; C07D317/60; C07D405/06; C07D405/12; C07D521/00; (IPC1-7): C07C237/30; C07C237/42; C07D265/26; C07D317/60; C07D405/12; A61K31/36; A61K31/44; A61K31/445; A61K31/495
Foreign References:
| JPS5095285A | 1975-07-29 | |||
| JPS62242675A | 1987-10-23 | |||
| JPS57181041A | 1982-11-08 | |||
| JPS51133245A | 1976-11-18 | |||
| JPS6483073A | 1989-03-28 |
Other References:
See also references of EP 0686625A4
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