Title:
ANTI-A33 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2006/028197
Kind Code:
A1
Abstract:
It is intended to provide an antibody or a fragment of the antibody which can bind to A33, specifically attacks a tumor cell expressing A33 by using an immune system with ADCC or CDC and produces no HAHA; and a drug for preventing or treating presently intractable malignant tumors of various types such as solid tumor which contains the antibody or the antibody fragment as described above. Namely, an antibody capable of binding to A33 or a functional fragment thereof which is an A33-binding antibody produced by the hybridoma M10 (deposition number: FERM BP-10107), M96 (deposition number: FERM BP-10108), M165 (deposition number: FERM BP-10106), N26 (deposition number FERM BP-10109), Q47 (deposition number: FERM BP-10104), Q54 (deposition number: FERM BP-10105) or R5 (deposition number: FERM BP-10107) or its functional fragment; and a drug for preventing or treating tumor which contains the above antibody or its functional fragment.
Inventors:
KATAOKA SHIRO (JP)
TOMURA TAKAFUMI (JP)
OTANI NORIKO (JP)
TOMURA TAKAFUMI (JP)
OTANI NORIKO (JP)
Application Number:
PCT/JP2005/016576
Publication Date:
March 16, 2006
Filing Date:
September 02, 2005
Export Citation:
Assignee:
KIRIN BREWERY (JP)
KATAOKA SHIRO (JP)
TOMURA TAKAFUMI (JP)
OTANI NORIKO (JP)
KATAOKA SHIRO (JP)
TOMURA TAKAFUMI (JP)
OTANI NORIKO (JP)
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K16/30; C12N5/10; C12P21/08
Foreign References:
| JPS62111697A | 1987-05-22 | |||
| JP2004515230A | 2004-05-27 |
Other References:
TOMIZUKA K. ET AL: "Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies", PROC.NATL.ACAD.SCI. USA, vol. 97, no. 2, 18 January 2000 (2000-01-18), pages 722 - 727, XP002150871
WELT S. ET AL: "Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer", CLIN. CANCER RES., vol. 9, no. 4, April 2003 (2003-04-01), pages 1347 - 1353, XP002995035
See also references of EP 1801208A4
WELT S. ET AL: "Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer", CLIN. CANCER RES., vol. 9, no. 4, April 2003 (2003-04-01), pages 1347 - 1353, XP002995035
See also references of EP 1801208A4
Attorney, Agent or Firm:
Hiraki, Yusuke (3-20 Toranomon 4-chom, Minato-ku Tokyo 01, JP)
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