Title:
ANTI-AGING COMPOSITION COMPRISING LACTIC ACID BACTERIA-DERIVED EXTRACELLULAR VESICLE
Document Type and Number:
WIPO Patent Application WO/2019/004673
Kind Code:
A2
Abstract:
Disclosed in the specification is an anti-aging composition comprising, as an effective ingredient, extracellular vesicles that are complex physiologically active substances derived from lactic acid bacteria. The extracellular vesicles may be exosome-like vesicles with a diameter of 20 to 200 nm and the composition inhibits the expression of MMP-1 protein, thereby providing the effects of reducing skin wrinkles, improving skin elasticity, suppressing collagen reduction, and preventing ultraviolet light-induced skin damage.
Inventors:
KIM WANIL (KR)
CHO EUN-GYUNG (KR)
LEE TAE RYONG (KR)
CHO EUN-GYUNG (KR)
LEE TAE RYONG (KR)
Application Number:
PCT/KR2018/007166
Publication Date:
January 03, 2019
Filing Date:
June 25, 2018
Export Citation:
Assignee:
AMOREPACIFIC CORP (KR)
International Classes:
A61K8/99; A61Q17/04; A61Q19/00; A61Q19/08
Foreign References:
| KR20110025603A | 2011-03-10 |
Other References:
INOMATA S ET AL., J. INVEST. DERMATOL., vol. 120, no. 1, 2003, pages 128 - 134
LOYER XVION ACTEDGUI ABOULANGER CM: "Microvesicles as cell-cell messengers in cardiovascular diseases", CIRC RES, vol. 114, 2014, pages 345 - 53
OHNO SISHIKAWA AKURODA M: "Roles of exosomes and microvesicles in disease pathogenesis", ADV DRUG DELIV REV, vol. 65, 2013, pages 398 - 401, XP028996222, DOI: 10.1016/j.addr.2012.07.019
CAMUSSI, G.DEREGIBUS, M. C.BRUNO, S.CANTALUPPI, V.BIANCONE, L.: "Exosomes/microvesicles as a mechanism of cell-to-cell communication", KIDNEY INTERNATIONAL, vol. 78, no. 9, 2010, pages 838 - 848, XP002669206, DOI: 10.1038/ki.2010.278
BANG, CLAUDIATHOMAS THUM: "Exosomes: New players in cell-cell communication", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 44.11, 2012, pages 2060 - 2064
KIM, D. K.LEE, J.SIMPSON, R. J.LOTVALL, J.GHO, Y. S.: "Seminars in Cell & Developmental Biology", vol. 40, April 2015, ACADEMIC PRESS, article "EVpedia: A community web resource for prokaryotic and eukaryotic extracellular vesicles research", pages: 97 - 104
See also references of EP 3646851A4
LOYER XVION ACTEDGUI ABOULANGER CM: "Microvesicles as cell-cell messengers in cardiovascular diseases", CIRC RES, vol. 114, 2014, pages 345 - 53
OHNO SISHIKAWA AKURODA M: "Roles of exosomes and microvesicles in disease pathogenesis", ADV DRUG DELIV REV, vol. 65, 2013, pages 398 - 401, XP028996222, DOI: 10.1016/j.addr.2012.07.019
CAMUSSI, G.DEREGIBUS, M. C.BRUNO, S.CANTALUPPI, V.BIANCONE, L.: "Exosomes/microvesicles as a mechanism of cell-to-cell communication", KIDNEY INTERNATIONAL, vol. 78, no. 9, 2010, pages 838 - 848, XP002669206, DOI: 10.1038/ki.2010.278
BANG, CLAUDIATHOMAS THUM: "Exosomes: New players in cell-cell communication", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 44.11, 2012, pages 2060 - 2064
KIM, D. K.LEE, J.SIMPSON, R. J.LOTVALL, J.GHO, Y. S.: "Seminars in Cell & Developmental Biology", vol. 40, April 2015, ACADEMIC PRESS, article "EVpedia: A community web resource for prokaryotic and eukaryotic extracellular vesicles research", pages: 97 - 104
See also references of EP 3646851A4
Attorney, Agent or Firm:
KIM, Sun-young (KR)
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