Title:
ANTI-ANGIOGENESIS COMBINATION THERAPIES COMPRISING PYRIDAZINE OR PYRIDINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2003059354
Kind Code:
A3
Abstract:
The invention relates generally to the use of certain substituted fused or unfused pyridazine or pyridine derivatives which are KDR inhibitors in combination with other chemotherapeutic agents for use in treatment of diseases associated with abnormal angiogenesis and/or hyperpermeability and/or hyperproliferative diseases, such as cancer.
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Inventors:
ADAMS PAUL E (US)
BOYER STEPHEN J (US)
DUMAS JACQUES (US)
ELTING JAMES J (US)
KLUENDER HAROLD C E (US)
BOYER STEPHEN J (US)
DUMAS JACQUES (US)
ELTING JAMES J (US)
KLUENDER HAROLD C E (US)
Application Number:
PCT/US2002/041145
Publication Date:
November 13, 2003
Filing Date:
December 20, 2002
Export Citation:
Assignee:
BAYER PHARMACEUTICALS CORP (US)
ADAMS PAUL E (US)
BOYER STEPHEN J (US)
DUMAS JACQUES (US)
ELTING JAMES J (US)
KLUENDER HAROLD C E (US)
ADAMS PAUL E (US)
BOYER STEPHEN J (US)
DUMAS JACQUES (US)
ELTING JAMES J (US)
KLUENDER HAROLD C E (US)
International Classes:
A61K31/501; A61K31/502; A61K31/5025; A61K45/06; A61P35/00; (IPC1-7): A61K31/502; A61K31/5025; A61P35/00
Domestic Patent References:
| WO2002041882A2 | 2002-05-30 | |||
| WO1998035958A1 | 1998-08-20 | |||
| WO2001023375A2 | 2001-04-05 | |||
| WO2001010859A1 | 2001-02-15 |
Other References:
BAKER CHERYL H ET AL: "Angiogenesis and cancer metastasis: Antiangiogenic therapy of human pancreatic adenocarcinoma.", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 6, no. 2, April 2001 (2001-04-01), pages 59 - 65, XP002239209, ISSN: 1341-9625
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