FIELD OF INVENTION

[001] The present invention pertains generally to technical field of herbal formulations for use in arthritis and paralysis. Specifically, it pertains to anti-arthritic and anti-paralytic herbal topical oil formulation and process for the preparation thereof.

BACKGROUND OF THE INVENTION

[002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.

[003] Arthritis, which is commonly referred to as joint pain or joint diseases, can be of more than 100 types. Differing in severity, arthritis can affect the heart, eyes, lungs, kidneys and skin as well as the joints. Degenerative Arthritis, Inflammatory Arthritis, Infectious Arthritis, and Metabolic Arthritis are types of arthritis. Different treatment approaches including biologies, Disease-modifying Anti-Rheumatic Drugs (DMARDs), advanced therapies, and natural medicines, joint replacement surgeries, lifestyle changes, are available for arthritis. Currently used allopathic medications show different side- effects such as Edema, heartburn, stomach upset and stomach ulcers, increased risk of blood clots, heart attack and stroke, cataracts, elevated blood fats and blood sugar levels, increased appetite, bone loss, stomach upset, increased susceptibility to infection, Injection site reactions, including redness and swelling; infusion reactions (difficulty breathing, nausea, vomiting, rapid or weak pulse) and increased risk of serious infections. Side- effects can create serious troubles considering the chronic nature of treatment of arthritis. Joint replacement surgery cannot be performed at initial stages and cannot be performed at any stage for some joints. Changes brought about to the lifestyle can be helpful but in most of the cases, they are not sufficient in themselves for the treatment of arthritis.

[004] Paralysis, which results in loss of muscle function for one or more muscles, can be accompanied by a loss of feeling (sensory loss) in the affected area. Paralysis, depending on the part which has been affected by the paralysis, can be monoplegia (affecting only one limb), diplegia (affecting two limbs), paraplegia (affecting trunk and two limbs), hemiplegia (affecting one side of body), quadriplegia (trunk and all the four limbs). Paralysis like Arthritis has no cure. Symptoms can be treated with Allopathy which suffers from many side effects.

[005] There is therefore a need in the art to develop a new medicinal herbal formulation that shows synergistic effect of the individual herbs present in it, is less costly, shows fewer side effects as compared to the existing formulations, and can be prepared easily, reduces/alleviates pain, swelling, and increases range of motion. There is also need to develop formulations which in addition to showing desired parameters as above, also show anti-paralytic effect.

[006] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply.

[007] In some embodiments, the numbers expressing quantities of ingredients, properties such as concentration, reaction conditions, and so forth, used to describe certain embodiments of the invention are to be understood as being modified in some instances by the term "about." Accordingly, in some embodiments, the numerical parameters set forth in the written description are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements. [008] As used in the description herein and throughout the claims that follow, the meaning of "a," "an," and "the" includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of "in" includes "in" and "on" unless the context clearly dictates otherwise.

[009] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g. "such as") provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.

[0010] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability.

OBJECTS OF THE INVENTION

[0011] It is an object of the present invention to provide a novel anti-arthritic and anti- paralytic medicinal herbal formulation that shows synergistic effect of the individual herbs present in it.

[0012] Yet another object of the present invention is to provide a novel cost effective anti- arthritic and anti-paralytic medicinal herbal formulation.

[0013] Yet another object of the present invention is to provide a novel anti-arthritic and anti-paralytic medicinal herbal formulation that exhibits fewer side effects as compared to existing formulations.

[0014] Yet another object of the present invention is to provide a novel anti-arthritic and anti-paralytic medicinal herbal formulation that can be easily prepared. [0015] Yet another object of the present invention is to provide a novel anti-arthritic and anti-paralytic medicinal herbal formulation that reduces/alleviates pain, swelling, and increases range of motion. SUMMARY OF THE INVENTION

[0016] In an aspect of the present invention, there is provided a composition comprising extract of at least one plant selected from Table 1.

[0017] In another aspect of the present invention, there is provided a method of preparing a composition comprising extract of at least one plant selected from Table 1, said method comprising: (a) obtaining at least one part of at least one plant selected from Table 1; (b) dehydrating said plant part(s) to obtain extract(s); and (c) contacting said extract(s) with at least one oil and cow urine at a temperature in the range of 107-150°C for a time period of 75-95 hours to obtain said composition.

[0018] In yet another aspect of the present invention, there is provided a method of preparing a composition comprising extract of at least one plant selected from Table 1, and Table 2, said method comprising: (a) obtaining at least one part of at least one plant selected from Table 1 ; (b) obtaining at least one part of plants as set forth in Table 2; (c) dehydrating said plant part(s) to obtain extract(s); and (d) contacting said extracts(s) with at least one oil and cow urine at a temperature in the range of 107-150°C for a time period of 75-95 hours to obtain said composition.

DETAILED DESCRIPTION OF THE INVENTION

[0019] Unless the context requires otherwise, throughout the specification which follow, the word "comprise" and variations thereof, such as, "comprises" and "comprising" are to be construed in an open, inclusive sense that is as "including, but not limited to."

[0020] In the following description, numerous specific details are set forth in order to provide a thorough understanding of embodiments of the present invention. It will be apparent to one skilled in the art that embodiments of the present invention may be practiced without some of these specific details.

[0021] Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

[0022] As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. It should also be noted that the term "or" is generally employed in its sense including "and/or" unless the content clearly dictates otherwise.

[0023] Each of the appended claims defines a separate invention, which for infringement purposes is recognized as including equivalents to the various elements or limitations specified in the claims. Depending on the context, all references below to the "invention" may in some cases refer to certain specific embodiments only. In other cases it will be recognized that references to the "invention" will refer to subject matter recited in one or more, but not necessarily all, of the claims.

[0024] Various terms as used herein are shown below. To the extent a term used in a claim is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.

[0025] Each of the appended claims defines a separate invention, which for infringement purposes is recognized as including equivalents to the various elements or limitations specified in the claims. Depending on the context, all references below to the "invention" may in some cases refer to certain specific embodiments only. In other cases it will be recognized that references to the "invention" will refer to subject matter recited in one or more, but not necessarily all, of the claims.

[0026] Various terms as used herein are shown below. To the extent a term used in a claim is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.

[0027] The embodiments are in such detail as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims.

[0028] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments. Reference will now be made in detail to the exemplary embodiments of the present invention.

[0029] In an embodiment of the present invention, there is provided a composition comprising extract of at least one part of at least one plant selected from Table 1. In an embodiment, the said composition is a liquid composition. In an embodiment, the composition is a liquid composition with viscosity greater than that of water. In a preferred embodiment, the said composition comprises extract at least one part of each of the plants of Table 1. In a more preferred embodiment, the said composition comprises extracts of part of plants as set forth in Table 1.

[0030] In an embodiment of the present invention, there is provided a composition as described herein, further comprisingextract of at least one part of at least one plantas set forth in Table 2. In a preferred embodiment, the said composition comprises extract of at least one part of plants as set forth in Table 2. In a more preferred embodiment, the composition comprises extract of part of plants as set forth in Table 2.

[0031] In a most preferred embodiment, there is provided a composition comprising extract of part of plant as set forth in Table 1 and extract of part of plants as set forth in Table 2.

[0032] In an embodiment of the present invention, the plant part of plant as set forth in Table 1 or 2is selected from the group consisting of seeds, flowers, roots, shoots, whole plant, and combinations thereof. In an embodiment, the said plant partsare dehydrated to prepare extract of said plant part. In an embodiment, dehydration can be carried out naturally under the sun or shade to obtain a sufficiently dehydrated product which is within the purview of a person skilled in the art. Alternatively, the parts may be dehydrated under artificial conditions of elevated temperature, lower pressure or combination thereof. In an embodiment, the extracts are comprised in said composition.

[0033] In an embodiment of the present invention, there is provided a composition comprising extracts of plant parts selected from Table 1 as described herein, wherein w/w ratio of any two extracts of plant parts selected from Table 1 is in the range of 1 :3 to 3: 1, preferably 1 : 1. In a preferred embodiment, the composition comprises extracts of plants of Table 1 , wherein the w/w ratio of the 5 extracts of plants part in Table 1 is preferably 1 : 1.

[0034] In an embodiment of the present invention, there is provided a composition comprising extracts of plant parts selected from Table 2 as described herein, wherein w/w ratio of any two extracts of plant parts selected from Table 2 is in the range of 1 :3 to 3: 1, preferably 1 : 1. In a preferred embodiment, the composition comprises extracts of plants of Table 2, wherein the w/w ratio of the 63 extracts of plant parts in Table 2 is 1 : 1.

[0035] In a most preferred embodiment of the present invention, there is provided a composition comprising extract of plant parts as set forth in Table 1 and Table 2, wherein w/w ratio of extracts of plants of Tablel or Table 2 is 1 : 1.

[0036] In a preferred embodiment of the present invention, there is provided a composition comprising extracts of plant parts as set forth in Table 1 and Table 2 as described herein, wherein w/w ratio extracts of plant parts as set forth in Table 1 to extracts of plant parts as set forth in Table 2 is in the range of 1 :5 to 5: 1, preferably 1 :3.15.

[0037] In an embodiment of the present invention, there is provided a composition as described herein, further comprising at least one oil and cow urine. In an embodiment, said at least one oil is obtained from plant parts including seeds, and combinations thereof. In an embodiment, said oil can be selected from the group consisting of, but not limited to, coconut oil, corn oil, cottonseed oil, olive oil, palm oil, peanut oil, rapeseed oil, safflower oil, sesame oil, soybean oil, sunflower oil, mustard oil, almond oil, beech oil, brazil nut oil, cashew oil, hazelnut oil, macadamia oil, pecan oil, pine nut oil, walnut oil, citrus oils such as grapefruit seed oil, lemon oil, orange oil, oils from gourds and melons, flaxseed oil, hemp oil, any other edible oil, and combinations thereof. In a preferred embodiment, said at least one oil is a combination of two oils. In a more preferred embodiment, said oil is a combination of mustard oil and sesame oil. It is understood by a person skilled in the art that mustard and sesame oil may be substituted independently of each other, the primary factor being cost, and a secondary factor being oil smoke point.

[0038] In an embodiment of the present invention, there is provided a method of preparing a composition comprising extracts from Table 1, said method comprising: (a) obtaining at least one part of at least one plant selected from Table 1 ; (b) dehydrating said plant part(s) to obtain extract(s); and (c) contacting said extract(s) with at least one oil obtained from plant parts including seeds, and combinations thereof and cow urine at a temperature in the range of 107-150°C for a time period of 75-95 hours to obtain said composition. In a preferred embodiment, all plants and parts as set forth in Table 1 are selected. In an embodiment, said at least one oil is as described herein. In a preferred embodiment, said oil is mustard oil and sesame oil.

[0039] In an embodiment of the present invention, there is provided a method of preparing a composition comprising extracts from Table 1 and Table 2, said method comprising: (a) obtaining at least one part of at least one plant selected from Table 1; (b) obtaining at least one part of at least one plant selected from Table 2; (c) dehydrating said plant part(s) to obtain extract(s); and (d) contacting said extract(s) with at least one oil obtained from plant parts including seeds, and combinations thereof and cow urine at a temperature in the range of 107-150°C for a time period of 75-95 hours to obtain said composition. In a preferred embodiment, all plants of Table 1 and Table 2 are selected. In an embodiment, said at least one oil is as described herein. In a preferred embodiment, said oil is mustard oil and sesame oil.

[0040] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein heating is carried out in a closed container.

[0041] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein said composition is filtered prior to use.

[0042] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/v ratio of extract(s) obtained from plants part as set forth in Table 1 to mustard oil is in the range of 1 : 10 to 10: 1, w/v ratio of extract(s) obtained from plants part as set forth in Table 1 to sesame oil is in the range of 1 :8 to 8: 1, and v/v ratio of the combination of mustard and sesame oil to cow urine is in the range of 1 : 5 to 5: 1.

[0043] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/v ratio of extract(s) obtained from plants part as set forth in Table 2 to mustard oil is in the range of 1 :4 to 4: 1, w/v ratio of extract(s) obtained from plants part as set forth in Table 2 to sesame oil is in the range of 1 :3 to 3: 1, and v/v ratio of the combination of mustard and sesame oil to cow urine is in the range of 1 : 5 to 5: 1.

[0044] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/v ratio of extract(s) obtained from plants part as set forth in Table 1 to mustard oil is in the range of 1 :9 to 9: 1, w/v ratio of extract(s) obtained from plants part as set forth in Table 1 to sesame oil is in the range of 1 :7 to 7: 1, and v/v ratio of the combination of mustard and sesame oil to cow urine is in the range of 1 :4 to 4: 1.

[0045] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/v ratio of extract(s) obtained from plants part as set forth in Table 2 to mustard oil is in the range of 1 :3 to 3: 1, w/v ratio of extract(s) obtained from plants part as set forth in Table 2 to sesame oil is in the range of 1 :2 to 2: 1, and v/v ratio of the combination of mustard and sesame oil to cow urine is in the range of 1 :4 to 4: 1.

[0046] In a preferred embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/v ratio of extract(s) of plants part as set forth in Table 1 to mustard oil is 1 :8, w/v ratio of extract(s) of plants part as set forth in Table 1 to sesame oil is 1 :6, and v/v ratio of mustard and sesame oil to cow urine is 1 :3.8.

[0047] In a preferred embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/v ratio of extract(s) of plants part as set forth in Table 2 to mustard oil is 1 :2.5, w/v ratio of extract(s) of plants part as set forth in Table 1 to sesame oil is 1 : 1.9, and v/v ratio of mustard and sesame oil to cow urine is 1 :3.8.

[0048] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/w ratio of extracts from plants part as set forth in Table 1 is in the range of 1 : 3 to 3 : 1 , preferably 1 : 1.

[0049] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/w ratio of extracts from plants part as set forth in Table 2 is in the range of 1 : 3 to 3 : 1 , preferably 1 : 1. [0050] In an embodiment of the present invention, there is provided a method of preparing a composition as described herein, wherein w/w ratio of extracts from plants part as set forth in Table 1 to extracts from plants part as set forth in Table 2 is in the range of 1 :6 to 6: 1, preferably 4: 1.

[0051] In an embodiment of the present invention, there is provided a composition as described herein, wherein said composition is useful for treating arthritis.

[0052] In an embodiment of the present invention, there is provided a composition as described herein, wherein said composition is useful for treating paralysis.

[0053] In an embodiment of the present invention, there is provided a composition as described herein, wherein said composition is for topical application.

[0054] In an embodiment of the present invention, there is provided a composition as described herein, wherein said composition is useful for curative treatment of arthritis.

[0055] In an embodiment of the present invention, there is provided a composition as described herein, wherein said composition is useful for curative treatment of paralysis.

[0056] In an embodiment of the present invention, there is provided a composition as described herein, wherein said composition reduces swelling or pain associated with arthritis.

[0057] In an embodiment of the present invention, there is provided a composition as described herein, wherein said composition ameliorates loss of range of motion associated with arthritis.

[0058] In an embodiment of the present invention, there is provided a composition as described herein, wherein said composition ameliorates loss of range of motion associated with paralysis.

[0059] In an embodiment of the present invention, climbing staff plant is found in Palakkad, Idukki, Kollam, Pathanamthitta, Malappuram, Kannur, Thrissur, Wayanad, Kozhikkode districts of Kerala; Spanish Pellitory is found is found in parts of Himalayas and Northern states;Nux vomica is found in Kolhapur, Raigad, Ratnagiri, Sindhudurg districts of Maharashtra, Belgaum, Chikmagalur, Coorg, Mysore, N. Kanara, Shimoga, S. Kanara districts of Karnataka, All districts of Kerala and Tamil Nadu;WithaniaSomnifera is found in Palakkad, Wayanad districts of Kerala; White leadwort is found in all districts of Kerala; Cinnamomumtamala is found in subtropical areas in the Himalayas; Croton tiglium is found in Idukki, Kannur, Kollam, Kottayam, Malapuram, Palakkad, Pathanamthitta, Wynad districts of Kerala and ChennaiinTamilnadu; Clove tree is found in Dindigul, Kanniyakumari, Theni, Tirunelveli districts of Tamil Nadu and all districts of Kerala; Zingiberofficinale (Ginger) is found in Assam, Bihar, Delhi, Goa, Karnataka, Kerala, Madhya Pradesh, Maharashtra, Rajasthan, Sikkim, Tamil Nadu, Tripura, Uttar Pradesh, and West Bengal; Sesame is found west Bengal , Madhya Pradesh, Gujarat, Uttar Pradesh ,Andhra Pradesh, Maharashtra, and Tamil Nadu, Karnataka, and Orissa; Nerium is found in Hassan, Mysore districts of Karnataka; Nyctanthes arbor-tristis L is found in Ahmednagar, Nasik, Pune districts of Maharashtra, N. Kanara district of Karnataka, All districts of TamilNadu and Kerala; AlpiniaGalanga is found in Himalaya and Southern region of Western Ghats in India; Embeliaribes is found in some parts of Andhra Pradesh, Chhattisgarh, Orissa and eastern part of India; Jatrophacurcas L. is found in Belgaum, Chikmagalur, Coorg, Hassan, Mysore, N. Kanara, Shimoga, S. Kanara is found in all districts of Karnataka, all districts of Tamil Nadu and Kerala; Menthapiperita L. is found in Pune of Maharashtra and all districts of Tamil Nadu; Orange Jasmine is found in Kolhapur of Maharashtra, Chikmagalur, Coorg, Hassan, Mysore, N. Kanara, Shimoga of Karnataka, and All districts of Kerala; MyricaNagi is found in Uttarakhand; Myristicafragrans Houtt. is found in Sindhudurg of Maharashtra, throughout Kerala, and Kanniyakumari, Tirunelveli of Tamil Nadu; Indian spikenard is found in Meghalaya, Sikkim, Uttar Pradesh, Uttarakhand; Sweet Flag is found in Kottayam, Alappuzha, Idukki, Thiruvananthapuram, Kozhikkode, Wayanad, Thrissur, Ernakulam, Palakkad, Malappuram of Kerala; Allium sativum L. (garlic)is found in Andhra Pradesh, Uttar Pradesh, Madras and Gujarat; Black pepperis found inKerala, Tamil Nadu, karnatka, Konkan Region, Pondicherry;Apiumgraveolens (celery) is found in Dindigul, Nilgiri of Tamil Nadu; Areca catechu is found in all districts of Kerala; Indian birthwort is found in Belgaum, Chikmagalur, Coorg, Hassan, Mysore, N. Kanara, Shimoga districts of Karnataka, All districts of Kerala and Tamil Nadu; Asteracanthalongifolia is found in Madhya Pradesh, and Bihar; Margosa tree is found in Kerala; Ajwain is found in Rajastan; Indian Laburnum is found throughout India, except Jammu & Kashmir, Himachal Pradesh, Sikkim, Arunachal Pradesh; Cinnamomumcamphora is found in Satara of Maharashtra, Chikmagalur of Karnataka, Kasaragod, Thiruvananthapuram, Thrissur of Kerala, Dindigul, Kancheepuram, Nilgiri, and Salem of Tamil Nadu; Cinnamomumverum is found in all districts of Kerala; Turk's turban is found in Pune in Maharashtra, Bangalore, Hassan, Mysore in Karnataka, all districts of Kerala, and Tamil Nadu; Clitoriaternatea is found in Maharashtra, Karnataka, Tamil Nadu and Kerala; Ivy gourd is found in Kolhapur, Nasik, Pune, Raigad, Ratnagiri, Satara, Sindhudurg, Thane of Maharashtra, Belgaum, Mysore of Karnataka, all districts of Tamil Nadu and Kerala; Iryisp is found in Punjab and Himachal Pradesh; Koshatis found in Punjab and Haryana; Dodder is found in Kottayam, Alappuzha, Idukki, Kollam, Pathanamthitta, Wayanad, Kozhikkode of Kerala; Thorn apple is found in all districts of Kerala;Desmodiumgangeticum is found in Chikmagalur, Coorg of Karnataka and throughout Maharashtra and Kerala; Indian sarsaparilla is most commonly found in Maharashtra, and Bengal; Tellicherry is found in grafted Malabar plants grown on Mount Tellicherry; Bellyache bush is found in Kerala, Tamil Nadu, Karnataka and Gujarat; Wild Basil is found foot hills of Himalaya, Himachal Pradesh, hilly Punjab;Oroxylumindicum is found in Himachal Pradesh, Punjab, Konkan area, Western Ghat and Coromandel Coast; Screwpine is found in Himalaya;Physalisperuviana is found in Kottayam, Idukki, Kollam, Pathanamthitta, Palakkad, Wayanad districts of Kerala; Cedrusdeodara is found in Kerala and Tamil Nadu; Indian Beech is mainly found in Maharashtra, Kerala, Karnataka, and Tamil Nadu; Styphnolobiumjaponicum is found in Maharashtra, Bengal and Gujarat; Rauwolfia serpentine is found in Pune, Raigad, Ratnagiri, Satara, Sindhudurg, Thane of Maharashtra, Chikmagalur, Dharwar, N. Kanara, Shimoga, S. Kanara of Karnataka, all districts of Kerala, and Kanniyakumari, Nilgiri, Tirunelveli of Tamil Nadu; Ricinuscommunis is found in Chikmagalur, Hassan, Mysore, Shimoga of Karnataka, all districts of Tamil Nadu and Kerala; Rubiatinctorum L. is found in Chikmagalur of Karnataka; Shorearobusta is found in Karnataka, Madhya Pradesh, Uttar Pradesh and Uttarakhand; Black nightshade is found in Coimbatore, Nilgiri of Tamil Nadu and throughout Maharashtra; Fenugreek is found throughout Maharashtra; Indian privet is found in all districts of Kerala; Juniper berry is found in Himalayas; Mexican poppy is found in Idukki, Malappuram, Palakkad, Kollam, Wayanad of Kerala; Elephant creeper is found in Kolhapur, Pune, Raigad, Thane of Maharashtra, Belgaum, Chikmagalur, Mysore, N. Kanara of Karnataka, All districts of Kerala, Coimbatore, Nilgiri, Tirunelveli of Tamil Nadu; Spiny Barleria is found in Maharashtra, Karnataka, Kerala and Tamil Nadu; Swallowwort is found in Punjab, Haryana and Uttar Pradesh; Clerodendrumphlomidis is found in Maharashtra, Karnataka and Tamil Nadu; Rosha grass is found in Maharashtra, Karnataka, Andhra Pradesh and Uttar Pradesh; Garden quinine is found in Kottayam, Alappuzha, Kasaragode, Kollam, Palakkad, Kannur, Thiruvananthapuram, Malappuram, Kozhikkode, Wayanad, Thrissur, Ernakulam districts of Kerala; Small pepper is found in parts of Himalayas.

[0060] Although the subject matter has been described in considerable detail with reference to certain preferred embodiments thereof, other embodiments are possible.

EXAMPLES

[0061] The disclosure will now be illustrated with working examples, which is intended to illustrate the working of disclosure and not intended to take restrictively to imply any limitations on the scope of the present disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice of the disclosed methods and compositions, the exemplary methods, devices and materials are described herein. It is to be understood that this disclosure is not limited to particular methods, and experimental conditions described, as such methods and conditions may vary.

Table 1

Name Part

Malkangani (Celastruspaniculatus) Seeds

Akarkara (Anacyclus pyrethrum) Flower

Kushala (Nux vomica) Seeds

Ashavgandha (Withaniasomnifera) Roots and leaves

Chitrak (Plumbagozeylanica) Root

Table 2

Name Part

Tejpat (Cinnamomumtamala) Leaves

Jamalgota (Croton Tigluim) Seeds Long/clove (Syzygiumaromaticum) Dried flower bud

Shunthi/ginger (Zingiberofficinale) Root

Sesame (Sesamumindicum) Seed

Belladonna (Amaryllis Belladonna) Bulb

Kaner (Thevetiaper viana) Leaves

Harsingar (Nyctantches arbor-tristis) Flower

Rasana (PlucheaLanceolata) Leaves

Vayebding (embelliaribes(Burman. F) Seeds

Jangliarend (Jatrophacurcas) Root

Peppermint (Menthapiperata(Linn) Whole plant

Karmin (Murrayapaniculata) Flower

Kayefal (myricanagi thumb. M. Esculanta) Root

Nutmeg (M. malabarica) Fruit

Jatamansi (Nardostachysjatamansi DC) Root

Vacha (Acoruscalamus) Root

Garlic (Allium sativum) Cloves

Black pepper (Piper nigrum) Fruit

Badiajwain (Apiumgraveolens) Seeds

Poogifal (Areca catechu) Fruit

Rudarjata/Indian birthwort Root

(Aristolochiaindica)

Talamkhana (Astercanthalongifolia) Seeds

Neem (Azadirachtaindica) Leaves

Ajwayan (Trachyspermumammi) Seeds

Amaltas (Cassia fistula) Fruit

Camphor (Cinnamomumcamphora) Whole plant

Cinnamon (Cinnamomumverum) Bark bharandieng:- turkisturbon Root

(clerodendronserratumspreng)

Aparajita (Clitoriaternatea) Root

Ivy gourd (Cocciniagrandis) Whole plant

Patharchur (Bergenialigulata) Leaf kebukkand (costusspeciosus (koenjsmith) Stem and roots

Dodder (Cuscuta) Stem and seeds

Thorn apple (Daturastramonium) Leaves and roots

Sarveen(Desmodiumgangeticum. DC) Root

Anantmool (Hemidesmusindicus) Root

Kootaj (Holarrhenaantidysenterica (Wall) Bark

Ratan jot /alkanet (Alkannatinctoria) Whole plant

Kali tulsi/Indian basil Seeds sonapatha (oroxylumindicum vent) Roots

Screw pine/kevada Root (Pandan usamaryllifolius)

Rasbhari/cape gooseberry Leaves (Physalisperuviana)

cheed tree (Cedrusdeodara) Gum

karanj tree (Pongamiapinnata) Seeds

kherchampa (Magoliachampaca) Root

Sarapgandha (Raicwolfiaserpentina) Root

Caster oil plant Seed

Madder (RubiaTinctorum) Root

Sal tree (shorearobustagaertn) Bark

Kakmachi (Solanumnigrum) Any part

Fenugreek Seeds

Nirgundi (Vitexnegundo) Root

Peacock bird Feathers

Juniper berry Root

Mexican poppy Root

Elephant creeper (Argyreia nervosa) Whole plant

spiny yellow barleria (Baleriarotundifolia) Whole plant

Indian shallow wort (Calotropisprocera) Root

Clerodendrum Whole plant

garden quinine (Cinchona) Root

pahadipipal Fruit

Example 1

[0062] A composition "A" was prepared by the following method: (a) 500g of Malkangani seeds were dried under sun/shade to obtain an extract; (b)25g of each of plant parts of Table 2 were dried under sun/shade to obtain extracts; (c) the extracts from step (a) and step (b) were combined by contacting them with mustard oil (4000L), sesame oil (30L) and cow urine (27L) in a closed container and heated at a temperature in the range of 107-150°C for a time period of 75-95 hours. Gas build up was allowed to escape. At the end of the time period, the concoction was strained and filtered to obtain composition A. The composition was applied topically daily (preferably at night time before bed) to arthritic patients with swelling and pain in joints. The patients reported significant improvement in increase in joint movement and reduction in pain and swelling within 26- 30 days of application regimen.

Example 2

[0063] A composition "B" was prepared by the following method: (a) 500g of Akarkaraflowers were dried under sun/shade to obtain an extract; (b) 25g of each of plant parts of Table 2 were dried under sun/shade to obtain extracts; (c) the extracts from step (a) and step (b) were combined by contacting them with mustard oil (4000L), sesame oil (30L) and cow urine (27L) in a closed container and heated at a temperature in the range of 107-150°C for a time period of 75-95 hours. Gas build up was allowed to escape. At the end of the time period, the concoction was strained and filtered to obtain composition B. The composition was applied topically daily(preferably at night time before bed) to arthritic patients with swelling and pain in joints. The patients reported significant improvement in increase in joint movement and reduction in pain and swelling within 30- 34 days of application regimen.

Example 3

[0064] In a manner similar to that of Example 1 or 2, other compositions "C", "D", and "E" were prepared comprising kushala, ashavgandha, or chitrak respectively. For composition C patients reported improvement by23-26 days, for composition D patients reported improvement by 28-32 days, and for composition E patients reported improvement by 31-35 days.

Example 4

[0065] Next, a composition comprising malkangani and akarkara was prepared by (a) 250g of Akarkara flowers and 250g of malkagani seeds were dried under sun/shade to obtain an extract; (b) 25g of each of plant parts of Table 2 were dried under sun/shade to obtain extracts; (c) the extracts from step (a) and step (b) were combined by contacting them with mustard oil (4000L), sesame oil (30L) and cow urine (27L) in a closed container and heated at a temperature in the range of 107-150°C for a time period of 75-95 hours. Gas build up was allowed to escape. At the end of the time period, the concoction was strained and filtered. The composition was applied topically daily (preferably at night time before bed)to arthritic patients with swelling and pain in joints. The patients reported significant improvement in increase in joint movement and reduction in pain and swelling within 22-25 days of application regimen.

Example 5

[0066] Similar to Example 4, a composition comprising malkangani seeds extract and chitrak root extract was prepared. Patients reported improvement in various parameters within 26-29 days.

Example 6 [0067] Next, a composition comprising malkangani seed extract, akarkara flower extract, and kushala seeds extract was prepared by (a) 165g of Akarkara flowers, 165g of malkagani seeds, and 165g of kushala seeds were dried under sun/shade to obtain an extract; (b) 25g of each of plant parts of Table 2 were dried under sun/shade to obtain extracts; (c) the extracts from step (a) and step (b) were combined by contacting them with mustard oil (4000L), sesame oil (30L) and cow urine (27L) in a closed container and heated at a temperature in the range of 107-150°C for a time period of 75-95 hours. Gas build up was allowed to escape. At the end of the time period, the concoction was strained and filtered. The composition was applied topically daily(preferably at night time before bed) to arthritic patients with swelling and pain in joints. The patients reported significant improvement in increase in joint movement and reduction in pain and swelling within 17- 20 days of application regimen.

Example 7

[0068] Similar to Example 6, a composition comprising malkangani seeds extract, kushala seed extract, and chitrak root extract was prepared. Patients reported improvement in various parameters within 19-25 days.

Example 8

[0069] Next, a composition comprising malkangani seed extract, akarkara flower extract, kushala seeds extract, and ashavgandha root and leaves extract was prepared by (a) 125g of Akarkara flowers, 125g of malkagani seeds, 125g of kushala seeds, and 125 g of ashavgandha root and leaves were dried under sun/shade to obtain an extract; (b) 25g of each of plant parts of Table 2 were dried under sun/shade to obtain extracts; (c) the extracts from step (a) and step (b) were combined by contacting them with mustard oil (4000L), sesame oil (30L) and cow urine (27L) in a closed container and heated at a temperature in the range of 107-150°C for a time period of 75-95 hours. Gas build up was allowed to escape. At the end of the time period, the concoction was strained and filtered. The composition was applied topically daily (preferably at night time before bed)to arthritic patients with swelling and pain in joints. The patients reported significant improvement in increase in joint movement and reduction in pain and swelling within 12- 15 days of application regimen.

Example 9 [0070] Similar to example 8, a composition comprising malkangani seed extract, akarkara flower extract, kushala seeds extract, and chitrak root extract was prepared. Patients reported improvement in various parameters within 14-18 days.

Example 10

[0071] Next, a composition comprising malkangani seed extract, akarkara flower extract, kushala seeds extract, ashavgandha root and leaves extract, and chitrak root extract was prepared by (a) lOOg of Akarkara flowers, lOOg of malkagani seeds, lOOg of kushala seeds, lOOg of ashavgandha root and leaves, and lOOg chitrak root were dried under sun/shade to obtain an extract; (b) 25g of each of plant parts of Table 2 were dried under sun/shade to obtain extracts; (c) the extracts from step (a) and step (b) were combined by contacting them with mustard oil (4000L), sesame oil (30L) and cow urine (27L) in a closed container and heated at a temperature in the range of 107-150°C for a time period of 75-95 hours. Gas build up was allowed to escape. At the end of the time period, the concoction was strained and filtered. The composition was applied topically daily (preferably at night time before bed)to arthritic patients with swelling and pain in joints. The patients reported significant improvement in increase in joint movement and reduction in pain and swelling within 7-10 days of application regimen.

Discussion

[0072] It can be appreciated from the above examples that the extracts of plants as shows in Table 1 is able to provide therapeutic advantage to arthritic patients suffering from loss in range of joint movement, pain, and swelling in joints. Particularly, unexpectedly and surprisingly, it is seen that for a particular combination of extracts as described in Example 10, patients reported beneficial effects in as less as 7-10 days compared to a similar effect reported over a longer duration of time (Examples 1-9) for extracts obtained from other combinations of plants of Table 1. It is also to be appreciated that not all combinations of plant extracts show a beneficial synergistic effect, as in numerous instances (as shown in Examples 1-9), not all combinations show an incremental beneficial effect.

[0073] Overall, the present invention provides a novel composition and method of preparing the said composition, which essentially comprises extracts from particular parts of 5 different plants (Table 1), which provides synergism in benefitting arthritic patients. The composition further comprises a collection of about 63 other extracts (table 2). The composition is made using mustard and sesame oil (having high smoke point and being cheap), and cow urine.