ANTI-B7-H7 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Title:

ANTI-B7-H7 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/138579

Kind Code:

A1

Abstract:

Disclosed are an anti-B7-H7 antibody or an antigen-binding fragment thereof, a preparation method therefor and the use thereof. The antibody comprises VL and/or VH; the VL comprises CDRs or mutations thereof: LCDR1, LCDR2 and LCDR3 as shown in amino acid sequences of SEQ ID NO: 82, SEQ ID NO: 94-100, and SEQ ID NOs: 111, 112, 114-116, 120 and 121; and the VH comprises CDRs or mutations thereof: HCDR1, HCDR2 and HCDR3 as shown in the amino acid sequence of SEQ ID NO: 7, SEQ ID NO: 34 or 36, and SEQ ID NO: 57-68. The anti-B7-H7 antibody or antigen-binding fragment thereof of the present invention has high affinity and high biological activity for B7-H7, and can effectively block the binding of B7-H7 to a receptor CD28H thereof and the binding of B7-H7 to a receptor KIR3DL3 thereof; furthermore, the anti-B7-H7 antibody or antigen-binding fragment thereof only specifically binds to B7-H7 without cross-reacting with other member proteins of the B7 family, and has good stability; in addition, the anti-B7-H7 antibody or antigen-binding fragment thereof shows strong in-vivo anti-tumor activity.

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Inventors:

WU XIAODONG (CN)
WANG YONGQIANG (CN)
LV XIAOCHENG (CN)
CHEN FEI (CN)
LI XUEMEI (CN)
ZHAO JIUQIAO (CN)
RONG YIPING (CN)

Application Number:

PCT/CN2023/072622

Publication Date:

July 27, 2023

Filing Date:

January 17, 2023

Export Citation:

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Assignee:

HARBOUR BIOMED US INC (US)

International Classes:

C07K16/28; A61K39/395; A61P35/00; C07K16/46; C07K19/00; C12N5/10; C12N15/13; C12N15/63; G01N33/50

Foreign References:

CN106414489A	2017-02-15
CN112153977A	2020-12-29
CN112930357A	2021-06-08
US20160002337A1	2016-01-07

Attorney, Agent or Firm:

LIU , SHEN & ASSOCIATES (CN)

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