Title:
ANTI-BAG3 ANTIBODIES FOR THERAPEUTIC USE
Document Type and Number:
WIPO Patent Application WO/2014/147503
Kind Code:
A3
Abstract:
The present invention relates to the use of BAG3 antibodies as a medicament, particular for use in the treatment of pancreatic tumours or other pathologies of immune, inflammatory, neoplastic and/or degenerative nature.
Inventors:
TURCO MARIA CATERINA (IT)
Application Number:
PCT/IB2014/059416
Publication Date:
December 04, 2014
Filing Date:
March 04, 2014
Export Citation:
Assignee:
BIOUNIVERSA SRL (IT)
International Classes:
A61P35/00; A61K39/395; C07K16/18; C07K16/30
Domestic Patent References:
| WO2003055908A2 | 2003-07-10 | |||
| WO2011067377A1 | 2011-06-09 | |||
| WO2013189775A1 | 2013-12-27 |
Other References:
A.FALCO: "Ruolo della proteina BAG3 nel micro ambiente tumorale", 2011, XP002714756, Retrieved from the Internet [retrieved on 20131014]
MICHELINA FESTA ET AL: "BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy", AMERICAN JOURNAL OF PATHOLOGY; [10640], AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY, US, vol. 178, no. 6, 1 June 2011 (2011-06-01), pages 2504 - 2512, XP002685427, ISSN: 0002-9440, [retrieved on 20110510], DOI: 10.1016/J.AJPATH.2011.02.002
ROSATI ALESSANDRA ET AL: "Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival.", THE AMERICAN JOURNAL OF PATHOLOGY NOV 2012, vol. 181, no. 5, November 2012 (2012-11-01), pages 1524 - 1529, XP002714757, ISSN: 1525-2191
WANG HUA-QIN ET AL: "Characterization of BAG3 Cleavage During Apoptosis of Pancreatic Cancer Cells", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 224, no. 1, July 2010 (2010-07-01), pages 94 - 100, XP002714758, ISSN: 0021-9541
MICHELINA FESTA ET AL: "BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy", AMERICAN JOURNAL OF PATHOLOGY; [10640], AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY, US, vol. 178, no. 6, 1 June 2011 (2011-06-01), pages 2504 - 2512, XP002685427, ISSN: 0002-9440, [retrieved on 20110510], DOI: 10.1016/J.AJPATH.2011.02.002
ROSATI ALESSANDRA ET AL: "Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival.", THE AMERICAN JOURNAL OF PATHOLOGY NOV 2012, vol. 181, no. 5, November 2012 (2012-11-01), pages 1524 - 1529, XP002714757, ISSN: 1525-2191
WANG HUA-QIN ET AL: "Characterization of BAG3 Cleavage During Apoptosis of Pancreatic Cancer Cells", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 224, no. 1, July 2010 (2010-07-01), pages 94 - 100, XP002714758, ISSN: 0021-9541
Attorney, Agent or Firm:
PISTOLESI, Roberto et al. (Via Nino Bixio 7, Milano, IT)
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