Title:
ANTI-CADHERIN ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2010/126137
Kind Code:
A1
Abstract:
Provided is an anti-cadherin antibody having strong antibody-dependent cytotoxicity. The anti-cadherin antibody recognizes cadherin domain 4 (EC4), cadherin domain (EC5), or a domain upstream from EC1, and has an antibody-dependent cytotoxicity of 30% or greater at an antibody concentration of 1 µg/mL.
Inventors:
ABURATANI HIROYUKI (JP)
ZHANG LILIN (JP)
ISHII KEISUKE (JP)
KOUDA KATSUSHI (JP)
SAKAMOTO AYA (JP)
KATSUMI KEIKO (JP)
ONISHI HIROSHI (JP)
KAYUKAWA YOKO (JP)
ZHANG LILIN (JP)
ISHII KEISUKE (JP)
KOUDA KATSUSHI (JP)
SAKAMOTO AYA (JP)
KATSUMI KEIKO (JP)
ONISHI HIROSHI (JP)
KAYUKAWA YOKO (JP)
Application Number:
PCT/JP2010/057694
Publication Date:
November 04, 2010
Filing Date:
April 30, 2010
Export Citation:
Assignee:
UNIV TOKYO (JP)
PERSEUS PROTEOMICS INC (JP)
ABURATANI HIROYUKI (JP)
ZHANG LILIN (JP)
ISHII KEISUKE (JP)
KOUDA KATSUSHI (JP)
SAKAMOTO AYA (JP)
KATSUMI KEIKO (JP)
ONISHI HIROSHI (JP)
KAYUKAWA YOKO (JP)
PERSEUS PROTEOMICS INC (JP)
ABURATANI HIROYUKI (JP)
ZHANG LILIN (JP)
ISHII KEISUKE (JP)
KOUDA KATSUSHI (JP)
SAKAMOTO AYA (JP)
KATSUMI KEIKO (JP)
ONISHI HIROSHI (JP)
KAYUKAWA YOKO (JP)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N5/10; C12N15/09
Domestic Patent References:
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| WO2002097395A2 | 2002-12-05 | |||
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Other References:
YUTAKA SHIMOYAMA ET AL.: "Molecular Cloning of a Human Ca2+-dependent Cell-Cell Adhesion Molecule Homologous to Mouse Placental Cadherin: Its Low Expression in Human Placental Tissues", THE JOURNAL OF CELL BIOLOGY, vol. 109, 1 October 1989 (1989-10-01), pages 1787 - 1794, XP008159562
See also references of EP 2426149A4
YOSHIDA; TAKEICHI, CELL, vol. 28, 1982, pages 217 - 224
NOSE A. ET AL., CELL, vol. 61, 1990, pages 147 - 155
KLINGEL H. ET AL., J OF CELL SCIENCE, vol. 113, 2000, pages 2829 - 36
THOMPSON JD ET AL., NUCLEIC ACIDS RESEARCH, vol. 22, no. 22, 1994, pages 3673 - 3680
THOMPSON JD ET AL., NUCLEIC ACIDS RESEARCH, vol. 25, no. 24, 1997, pages 4876 - 4882
SAMBROOK, J ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2426149A4
YOSHIDA; TAKEICHI, CELL, vol. 28, 1982, pages 217 - 224
NOSE A. ET AL., CELL, vol. 61, 1990, pages 147 - 155
KLINGEL H. ET AL., J OF CELL SCIENCE, vol. 113, 2000, pages 2829 - 36
THOMPSON JD ET AL., NUCLEIC ACIDS RESEARCH, vol. 22, no. 22, 1994, pages 3673 - 3680
THOMPSON JD ET AL., NUCLEIC ACIDS RESEARCH, vol. 25, no. 24, 1997, pages 4876 - 4882
SAMBROOK, J ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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