Title:
ANTI-CANCER BINDING MOLECULE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/036043
Kind Code:
A1
Abstract:
Provided are an anti-cancer binding molecule and the use thereof, and specifically provided is a bispecific binding molecule of 4-1BB and GPC3. The bispecific binding molecule comprises a first domain that specifically binds to 4-1BB, and a second domain that specifically binds to GPC3. Further provided is the use of the bispecific binding molecule in the treatment or prevention of cancers.
Inventors:
MENG XIANGXUE (CN)
SHI JIYA (CN)
JIE MIAOXING (CN)
YANG MIN (CN)
WANG YAQIU (CN)
REN ZHIHENG (CN)
CHEN LIMO (CN)
LI WENJIA (CN)
SHI JIYA (CN)
JIE MIAOXING (CN)
YANG MIN (CN)
WANG YAQIU (CN)
REN ZHIHENG (CN)
CHEN LIMO (CN)
LI WENJIA (CN)
Application Number:
PCT/CN2022/116450
Publication Date:
March 16, 2023
Filing Date:
September 01, 2022
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07K16/30; A61K39/395; A61P35/00; C07K16/46; C07K19/00; C12N15/13; C12N15/64; C12N15/85
Domestic Patent References:
| WO2020173897A1 | 2020-09-03 | |||
| WO2017196764A1 | 2017-11-16 |
Foreign References:
| CN113166247A | 2021-07-23 | |||
| CN112739718A | 2021-04-30 | |||
| CN108112253A | 2018-06-01 | |||
| CN115315447A | 2022-11-08 |
Other References:
BIRGIT BOSSENMAIER; CORINNA SCHLOSSER; RACHIDA SIHAM BEL AIBA; CHRISTIAN BARTHELS; BENJAMIN WEICHE; TIMO EICHNER; MICHELLE YEGRES;: "Abstract 3268: Costimulatory T-cell engagement by PRS-342, a GPC3/4-1BB bispecific molecule, leads to activation of T-cells and tumor growth inhibition in a HCC humanized mouse model.", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 79, no. 13_Supplement, 1 July 2019 (2019-07-01), US, XP009544224, ISSN: 0008-5472, DOI: 10.1158/1538-7445.AM2019-3268
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