Title:
ANTI-CCR8 ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/040216
Kind Code:
A3
Abstract:
Provided herein are isolated monoclonal antibody anti-CCR8 antibodies, antigen binding fragments thereof, mutants thereof, variants thereof and uses thereof for the treatment of diseases such as cancer. The mutant antibodies have a complementarity-determining region 3 modified to eliminate post-translational modification, and to improve stability and potency of the antibody. The variant antibodies have various levels of afucosylation. Also provided herein are methods of use of the anti-CCR8 antibodies, including methods of treatment of cancer. Also provided are polynucleotides encoding the heavy chain or the light chain or the antigen-binding portion thereof described herein, and vectors, especially expression vector, including the polynucleotides described herein.
Inventors:
BROUSSEAU DAVID T (US)
WALKINSHAW GAIL (US)
WITSCHI CLAUDIA (US)
WALKINSHAW GAIL (US)
WITSCHI CLAUDIA (US)
Application Number:
PCT/US2023/072462
Publication Date:
April 11, 2024
Filing Date:
August 18, 2023
Export Citation:
Assignee:
FIBROGEN INC (US)
International Classes:
C07K16/28; A61K39/00; A61P35/00; C07K14/715
Domestic Patent References:
| WO2021163064A2 | 2021-08-19 | |||
| WO2021142002A1 | 2021-07-15 | |||
| WO2021194942A1 | 2021-09-30 | |||
| WO2022136647A1 | 2022-06-30 |
Attorney, Agent or Firm:
ENDEJANN, N. Nicole et al. (US)
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