Title:
ANTI-CD122 ANTIBODIES, ANTI-CD132 ANTIBODIES, AND RELATED BISPECIFIC BINDING PROTEINS
Document Type and Number:
WIPO Patent Application WO/2023/078113
Kind Code:
A1
Abstract:
Provided are antibodies capable of binding CD122, antibodies capable of binding CD132, and bispecific CD122/CD132 binding proteins in FIT-Ig or duobody format prepared with antigen binding fragments thereof. The antibodies and bispecific binding proteins are useful for treating or preventing diseases such as T cell dysfunctional disorders or cancers.
Inventors:
GONG SHIYONG (CN)
HUANG LINI (CN)
WU CHENGBIN (CN)
WU DANQING (CN)
WU XUAN (CN)
ZHANG RUI (CN)
HUANG LINI (CN)
WU CHENGBIN (CN)
WU DANQING (CN)
WU XUAN (CN)
ZHANG RUI (CN)
Application Number:
PCT/CN2022/127036
Publication Date:
May 11, 2023
Filing Date:
October 24, 2022
Export Citation:
Assignee:
EPIMAB BIOTHERAPEUTICS HK LTD (CN)
International Classes:
C07K16/28; A61K39/00; C07K16/46
Domestic Patent References:
| WO2019092181A1 | 2019-05-16 | |||
| WO2017021540A1 | 2017-02-09 | |||
| WO2020160242A1 | 2020-08-06 | |||
| WO2011127324A2 | 2011-10-13 | |||
| WO2015103072A1 | 2015-07-09 |
Other References:
HARRIS KATHERINE E., LORENTSEN KYLE J., MALIK-CHAUDHRY HARBANI K., LOUGHLIN KAITLYN, BASAPPA HARISH MEDLARI, HARTSTEIN SHARON, AHM: "A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells", SCIENTIFIC REPORTS, vol. 11, no. 1, 1 December 2021 (2021-12-01), XP055905872, DOI: 10.1038/s41598-021-90096-8
CHANG，S. ET AL.: "Anti-γ Chain and Anti-IL-2Rβ mAbs in Combination With Donor Splenocyte Transfusion Induce H-Y Skin Grat Acceptance in Murine Model", TRANSPLANTATION PROCEEDINGS, vol. 41, 31 December 2009 (2009-12-31), pages 3913 - 3915, XP055789278
CHANG，S. ET AL.: "Anti-γ Chain and Anti-IL-2Rβ mAbs in Combination With Donor Splenocyte Transfusion Induce H-Y Skin Grat Acceptance in Murine Model", TRANSPLANTATION PROCEEDINGS, vol. 41, 31 December 2009 (2009-12-31), pages 3913 - 3915, XP055789278
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
Download PDF: