ANTI-CD137 ANTIGEN-BINDING MOLECULE FOR USE IN CANCER TREATMENT

Title:

ANTI-CD137 ANTIGEN-BINDING MOLECULE FOR USE IN CANCER TREATMENT

Document Type and Number:

WIPO Patent Application WO/2021/162020

Kind Code:

A1

Abstract:

[Problem] The purpose of the present disclosure is to provide: an anti-cancer agent having immune cell activation action, cytotoxic activity, or anti-tumor activity, and yet having little activity against non-tumor tissues such as normal tissues, and also having few side effects; a combination therapy that uses said anti-cancer agent together with other anti-cancer agents; and a pharmaceutical composition for use in the combination therapy. [Solution] Provided are: an anti-cancer agent; a combination therapy using the anti-cancer agent together with other anti-cancer agents; and a pharmaceutical composition for use in the combination therapy. This anti-cancer agent includes an anti-CD137 antigen-binding molecule according to the present disclosure as an active ingredient, where the binding activity of the molecule against CD137 varies depending on a variety of substances (e.g., low molecular compounds) on target tissues. As a result, the anti-cancer agent has immune cell activation action, cytotoxic activity, or anti-tumor activity, and yet has little activity against non-tumor tissues such as normal tissues, and also has few side effects. The anti-cancer agent is expected to be applicable to various types of cancer.

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Inventors:

SAKURAI MIKA (JP)
NARITA YOSHINORI (SG)
TANIGUCHI KENJI (JP)
MIKAMI HIROFUMI (JP)
HORIKAWA SAYURI (JP)
UCHIKAWA RYO (JP)
ONO NATSUKI (JP)
HAMADA KOKI (JP)

Application Number:

PCT/JP2021/004871

Publication Date:

August 19, 2021

Filing Date:

February 10, 2021

Export Citation:

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Assignee:

CHUGAI PHARMACEUTICAL CO LTD (JP)

International Classes:

A61K39/395; A61K45/00; A61P35/00; A61P43/00; C07K16/28; C07K16/30; C07K16/46; C12N15/13

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HARUNA, Masao et al. (JP)

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