Title:
ANTI-CD19 HUMANIZED ANTIBODY AND IMMUNE EFFECTOR CELL TARGETING CD19
Document Type and Number:
WIPO Patent Application WO/2018/108106
Kind Code:
A1
Abstract:
Disclosed are an anti-CD19 humanized antibody prepared from a murine monoclonal antibody, a chimeric antigen receptor containing the humanized antibody, and an immune cell expressing the humanized antibody. Not only does the humanized antibody of the present invention not produce an anti-antibody response (AAR) and a human anti-mouse antibody response (HAMA), but same also has better affinity than a murine antibody, and has excellent activity and safety, thereby providing a new means for treating CD19-expressing tumors.
Inventors:
WANG PENG (CN)
GAO HUIPING (CN)
SHI ZHIMIN (CN)
LI ZONGHAI (CN)
GAO HUIPING (CN)
SHI ZHIMIN (CN)
LI ZONGHAI (CN)
Application Number:
PCT/CN2017/115973
Publication Date:
June 21, 2018
Filing Date:
December 13, 2017
Export Citation:
Assignee:
CARSGEN THERAPEUTICS LTD (CN)
SHANGHAI CANCER INST (CN)
SHANGHAI CANCER INST (CN)
International Classes:
C07K16/28; A61K35/17; A61K39/395; A61P35/00; C07K19/00; C12N5/10; C12N7/01; C12N15/13; C12N15/63
Foreign References:
| CN102209556A | 2011-10-05 | |||
| CN105392888A | 2016-03-09 | |||
| CN102209556A | 2011-10-05 |
Other References:
NADLER ET AL., J. IMMUNOL., vol. 131, 1983, pages 244 - 250
LOKEN ET AL., BLOOD, vol. 70, 1987, pages 1316 - 1324
GROSSBARD ET AL., BR. J. HAEMATOL, vol. 102, 1998, pages 509 - 15
TREON ET AL., SEMIN. ONCOL, vol. 30, 2003, pages 248 - 52
J IMMUNOL, vol. 138, no. 9, 1 May 1987 (1987-05-01), pages 2793 - 9
VAHIDEH AHMADZADEH ET AL., MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY, vol. 33, no. 2, pages 2014
LEUKOCYTE TYPING II, pages 391 - 402
DAYHOFF ET AL., ATLAS OF PROTEIN SEQUENCE AND STRUCTURE, vol. 5, no. 3, 1978
J. SAMBROOK ET AL.: "Molecular Cloning Experiment Guide", 2002, SCIENCE PRESS
J IMMUNOL., vol. 138, no. 9, 1 May 1987 (1987-05-01), pages 2793 - 9
See also references of EP 3556772A4
LOKEN ET AL., BLOOD, vol. 70, 1987, pages 1316 - 1324
GROSSBARD ET AL., BR. J. HAEMATOL, vol. 102, 1998, pages 509 - 15
TREON ET AL., SEMIN. ONCOL, vol. 30, 2003, pages 248 - 52
J IMMUNOL, vol. 138, no. 9, 1 May 1987 (1987-05-01), pages 2793 - 9
VAHIDEH AHMADZADEH ET AL., MONOCLONAL ANTIBODIES IN IMMUNODIAGNOSIS AND IMMUNOTHERAPY, vol. 33, no. 2, pages 2014
LEUKOCYTE TYPING II, pages 391 - 402
DAYHOFF ET AL., ATLAS OF PROTEIN SEQUENCE AND STRUCTURE, vol. 5, no. 3, 1978
J. SAMBROOK ET AL.: "Molecular Cloning Experiment Guide", 2002, SCIENCE PRESS
J IMMUNOL., vol. 138, no. 9, 1 May 1987 (1987-05-01), pages 2793 - 9
See also references of EP 3556772A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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