Title:
ANTI-CD3 ANTIBODY, AND MOLECULE CONTAINING SAID ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2018/117237
Kind Code:
A1
Abstract:
The present invention provides: a novel antibody capable of binding to human CD3; or a molecule which is capable of binding to an antigen and contains the antibody.
Provided are: a novel antibody capable of binding to human CD3; a molecule which contains the antibody and is capable of binding to an antigen; a pharmaceutical composition which contains the antibody or the molecule as an active ingredient and has a cytotoxic activity; and others.
Inventors:
TAKAHASHI TOHRU (JP)
YOSHIMURA CHIGUSA (JP)
KOZUMA SHIHO (JP)
NAKAMURA KENSUKE (JP)
SUZUKI CHIKAKO (JP)
ICHIKAWA JUNYA (JP)
YOSHIMURA CHIGUSA (JP)
KOZUMA SHIHO (JP)
NAKAMURA KENSUKE (JP)
SUZUKI CHIKAKO (JP)
ICHIKAWA JUNYA (JP)
Application Number:
PCT/JP2017/046006
Publication Date:
June 28, 2018
Filing Date:
December 21, 2017
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/09; A61K39/395; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| WO2016116626A1 | 2016-07-28 | |||
| WO2015181098A1 | 2015-12-03 | |||
| WO2016076345A1 | 2016-05-19 | |||
| WO2012162067A2 | 2012-11-29 | |||
| WO2007108152A1 | 2007-09-27 | |||
| WO2008119567A2 | 2008-10-09 | |||
| WO2015026892A1 | 2015-02-26 | |||
| WO1990007861A1 | 1990-07-26 | |||
| WO2013147153A1 | 2013-10-03 | |||
| WO1999054342A1 | 1999-10-28 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO1990007861A1 | 1990-07-26 | |||
| WO1992001047A1 | 1992-01-23 | |||
| WO1992020791A1 | 1992-11-26 | |||
| WO1993006213A1 | 1993-04-01 | |||
| WO1993011236A1 | 1993-06-10 | |||
| WO1993019172A1 | 1993-09-30 | |||
| WO1995001438A1 | 1995-01-12 | |||
| WO1995015388A1 | 1995-06-08 | |||
| WO2004061104A2 | 2004-07-22 | |||
| WO2008119565A2 | 2008-10-09 |
Foreign References:
| JP2009511521A | 2009-03-19 | |||
| JP2014517844A | 2014-07-24 | |||
| US8236308B2 | 2012-08-07 | |||
| US6972323B1 | 2005-12-06 | |||
| US4946778A | 1990-08-07 | |||
| US5260203A | 1993-11-09 | |||
| US5091513A | 1992-02-25 | |||
| US5455030A | 1995-10-03 | |||
| US7129330B1 | 2006-10-31 | |||
| US6214388B1 | 2001-04-10 | |||
| EP2270053A1 | 2011-01-05 |
Other References:
SALMERON A ET AL., J. IMMUNOL., vol. 147, 1991, pages 3047 - 3052
COSMI AB ET AL., TRANSPLANTATION, vol. 32, 1981, pages 535 - 539
GILBERT EM ET AL., AM.J.MED., vol. 82, 1987, pages 202 - 206
THISTLETHWAITE JR ET AL., TRANSPLANATION, vol. 43, 1987, pages 176 - 184
ABRAMOWICZ D ET AL., TRANSPLANATION, vol. 48, 1989, pages 524 - 526
THISTLETHWAITE, JR ET AL., AM. J. KIDNEY DIS., vol. 11, 1988, pages 112 - 119
MEUER, SC ET AL., EUR. J. IMMUNOL., vol. 136, 1986, pages 4106 - 4112
GEORGE AJ ET AL., J. IMMUNOL., vol. 152, no. 4, 1994, pages 1802 - 11
WOODLE ES ET AL., J IMMUNOL, vol. 148, no. 9, 1992, pages 2756 - 63
YANKELEVICH M ET AL., PEDIATR. BLOOD CANCER, vol. 59, no. 7, 2012, pages 1198 - 1205
OHMACHI T ET AL., CLIN. CANCER RES, vol. 12, no. 18, 2006, pages 3857 - 3863
MUHLMANN G. ET AL., J. CLIN. PATHOL., vol. 62, no. 2, 2009, pages 152 - 158
FONG D. ET AL., BR. J. CANCER, vol. 99, no. 8, 2000, pages 1290 - 1295
FONG D ET AL., MOD. PATHOL., vol. 21, no. 2, 2000, pages 186 - 191
NING S. ET AL., NEUROL. SCI., vol. 34, no. 10, 2013, pages 1745 - 1750
SANDUSKY ET AL., J. MED. PRIMATOL., vol. 15, 1986, pages 441 - 451
UDA ET AL., J.MED.PRIMATOL., vol. 30, 2001, pages 141 - 147
CONRAD ML, CYTOMETRY A, vol. 71, no. 11, 2007, pages 925 - 33
LUM LG ET AL., BIODRUGS, vol. 25, no. 6, 2011, pages 365 - 379
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, vol. 27, 2003, pages 55 - 77
"GenBank", Database accession no. NM 001283615.1
SAIKI, R.K. ET AL., SCIENCE, vol. 239, 1988, pages 487 - 489
LARS KJER-NIELSEN ET AL., PNAS, vol. 101, no. 20, 2004, pages 16268 - 7680
MUYLDEMANS S ET AL., PROTEIN ENG., vol. 113, no. 9, 1994, pages 1129 - 315
NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 1126 - 1136
HAMERS-CASTERMAN C ET AL., NATURE, vol. 363, no. 6428, 1993, pages 446 - 448
LEE, H-S ET AL., MOLECULAR IMMUNOLOGY, vol. 36, 1999, pages 61 - 71
SHIRRMANN, T. ET AL., MAB S, vol. 2, no. 1, 2010, pages 1 - 4
NATURE, vol. 321, 1986, pages 522 - 525
MARJAN HEZAREH ET AL., JOURNAL OF VIROLOGY, vol. 75, no. 24, 2001, pages 12161 - 12168
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
CHODHFRURLAUB, GCHASIN, L.A., PNAS, vol. 77, 1980, pages 4126 - 4220
WEIR, D. M.: "Handbook of Experimental Immunology", vol. I. II. III., 1987, BLACKWELL SCIENTIFIC PUBLICATIONS
KABAT, E. A.MAYER, M. M.: "Experimental Immunochemistry", 1964, CHARLES C THOMAS PUBLISHER
KOHLER ET AL., EUR. J. IMMNOL., vol. 6, 1977, pages 511
MILSTEIN ET AL., NATURE, vol. 266, 1977, pages 495
SUBEDI GP ET AL., J VIS EXP, vol. 106, 2015
GLUZMAN, Y, CELL, vol. 23, 1981, pages 175 - 182
TOMIZUKA, K ET AL., NATURE GENETICS, vol. 16, 1997, pages 133 - 143
KUROIWA, Y, NUC. ACIDS RES., vol. 26, 1998, pages 3447 - 3448
YOSHIDA, H: "Animal Cell Technology: Basic and Applied Aspects", vol. 10, 1999, KLUWER ACADEMIC PUBLISHERS, pages: 69 - 73
TOMIZUKA, K, PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
ANNU. REV. IMMUNOL, vol. 12, 1994, pages 433 - 455
HUSTON, J.S. ET AL., PNAS, vol. 85, 1988, pages 5879 - 5883
METHODS MOL BIOL, vol. 1045, 2013, pages 1 - 27
PROTEIN ENG DES SEL, vol. 2, 2012, pages 81 - 8
PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
KIM, K.S. ET AL., J. MOL. BIOL., vol. 302, 2000, pages 899 - 916
SGRO: "Orthoclone, Janssen-Cilag", TOXICOLOGY, vol. 105, 1995, pages 23 - 29
METHODS IN ENZYMOLOGY, vol. 203, 1991, pages 121 - 153
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH
QUEEN ET AL., PNAS, vol. 86, 1989, pages 10029 - 10033
See also references of EP 3561057A4
COSMI AB ET AL., TRANSPLANTATION, vol. 32, 1981, pages 535 - 539
GILBERT EM ET AL., AM.J.MED., vol. 82, 1987, pages 202 - 206
THISTLETHWAITE JR ET AL., TRANSPLANATION, vol. 43, 1987, pages 176 - 184
ABRAMOWICZ D ET AL., TRANSPLANATION, vol. 48, 1989, pages 524 - 526
THISTLETHWAITE, JR ET AL., AM. J. KIDNEY DIS., vol. 11, 1988, pages 112 - 119
MEUER, SC ET AL., EUR. J. IMMUNOL., vol. 136, 1986, pages 4106 - 4112
GEORGE AJ ET AL., J. IMMUNOL., vol. 152, no. 4, 1994, pages 1802 - 11
WOODLE ES ET AL., J IMMUNOL, vol. 148, no. 9, 1992, pages 2756 - 63
YANKELEVICH M ET AL., PEDIATR. BLOOD CANCER, vol. 59, no. 7, 2012, pages 1198 - 1205
OHMACHI T ET AL., CLIN. CANCER RES, vol. 12, no. 18, 2006, pages 3857 - 3863
MUHLMANN G. ET AL., J. CLIN. PATHOL., vol. 62, no. 2, 2009, pages 152 - 158
FONG D. ET AL., BR. J. CANCER, vol. 99, no. 8, 2000, pages 1290 - 1295
FONG D ET AL., MOD. PATHOL., vol. 21, no. 2, 2000, pages 186 - 191
NING S. ET AL., NEUROL. SCI., vol. 34, no. 10, 2013, pages 1745 - 1750
SANDUSKY ET AL., J. MED. PRIMATOL., vol. 15, 1986, pages 441 - 451
UDA ET AL., J.MED.PRIMATOL., vol. 30, 2001, pages 141 - 147
CONRAD ML, CYTOMETRY A, vol. 71, no. 11, 2007, pages 925 - 33
LUM LG ET AL., BIODRUGS, vol. 25, no. 6, 2011, pages 365 - 379
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, vol. 27, 2003, pages 55 - 77
"GenBank", Database accession no. NM 001283615.1
SAIKI, R.K. ET AL., SCIENCE, vol. 239, 1988, pages 487 - 489
LARS KJER-NIELSEN ET AL., PNAS, vol. 101, no. 20, 2004, pages 16268 - 7680
MUYLDEMANS S ET AL., PROTEIN ENG., vol. 113, no. 9, 1994, pages 1129 - 315
NATURE BIOTECHNOLOGY, vol. 23, 2005, pages 1126 - 1136
HAMERS-CASTERMAN C ET AL., NATURE, vol. 363, no. 6428, 1993, pages 446 - 448
LEE, H-S ET AL., MOLECULAR IMMUNOLOGY, vol. 36, 1999, pages 61 - 71
SHIRRMANN, T. ET AL., MAB S, vol. 2, no. 1, 2010, pages 1 - 4
NATURE, vol. 321, 1986, pages 522 - 525
MARJAN HEZAREH ET AL., JOURNAL OF VIROLOGY, vol. 75, no. 24, 2001, pages 12161 - 12168
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
CHODHFRURLAUB, GCHASIN, L.A., PNAS, vol. 77, 1980, pages 4126 - 4220
WEIR, D. M.: "Handbook of Experimental Immunology", vol. I. II. III., 1987, BLACKWELL SCIENTIFIC PUBLICATIONS
KABAT, E. A.MAYER, M. M.: "Experimental Immunochemistry", 1964, CHARLES C THOMAS PUBLISHER
KOHLER ET AL., EUR. J. IMMNOL., vol. 6, 1977, pages 511
MILSTEIN ET AL., NATURE, vol. 266, 1977, pages 495
SUBEDI GP ET AL., J VIS EXP, vol. 106, 2015
GLUZMAN, Y, CELL, vol. 23, 1981, pages 175 - 182
TOMIZUKA, K ET AL., NATURE GENETICS, vol. 16, 1997, pages 133 - 143
KUROIWA, Y, NUC. ACIDS RES., vol. 26, 1998, pages 3447 - 3448
YOSHIDA, H: "Animal Cell Technology: Basic and Applied Aspects", vol. 10, 1999, KLUWER ACADEMIC PUBLISHERS, pages: 69 - 73
TOMIZUKA, K, PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
ANNU. REV. IMMUNOL, vol. 12, 1994, pages 433 - 455
HUSTON, J.S. ET AL., PNAS, vol. 85, 1988, pages 5879 - 5883
METHODS MOL BIOL, vol. 1045, 2013, pages 1 - 27
PROTEIN ENG DES SEL, vol. 2, 2012, pages 81 - 8
PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
KIM, K.S. ET AL., J. MOL. BIOL., vol. 302, 2000, pages 899 - 916
SGRO: "Orthoclone, Janssen-Cilag", TOXICOLOGY, vol. 105, 1995, pages 23 - 29
METHODS IN ENZYMOLOGY, vol. 203, 1991, pages 121 - 153
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH
QUEEN ET AL., PNAS, vol. 86, 1989, pages 10029 - 10033
See also references of EP 3561057A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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