Title:
ANTI CD70 CAR-T CELL, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/047208
Kind Code:
A1
Abstract:
Provided are a CAR-T cell specifically recognizing CD70, and a preparation method therefor. The method comprises expressing a SCFV(Anti CD70)-CD8 TM-4-1BB-CD3ζ molecule in a T cell. The CAR-T cell has tumor killing activity and may be used for preparing a medication in the treatment of a tumor with the high expression level of CD70 molecules.
Inventors:
GUO ZHIGANG (CN)
JI FENG (CN)
LIU RUI (CN)
WU TING (CN)
LI ENJIE (CN)
LI LULU (CN)
LI MENGHAN (CN)
HU ZHIGANG (CN)
JI FENG (CN)
LIU RUI (CN)
WU TING (CN)
LI ENJIE (CN)
LI LULU (CN)
LI MENGHAN (CN)
HU ZHIGANG (CN)
Application Number:
PCT/CN2020/092192
Publication Date:
March 18, 2021
Filing Date:
May 26, 2020
Export Citation:
Assignee:
ZHEJIANG BLUE SHIELD PHARMACEUTICAL CO LTD (CN)
International Classes:
C12N5/10; A61K39/00; A61P35/00; C12N15/62; C12N15/867
Domestic Patent References:
| WO2018132513A1 | 2018-07-19 |
Foreign References:
| CN110592023A | 2019-12-20 | |||
| CN105331586A | 2016-02-17 |
Other References:
CHONG-YANG TANG, HAI-TAO GE, ZHI-GUO LIN, HUANG JIAN-PING: "Potential Role of Runaway CD70 in the Occurrence and Treatment of Glioma", PROGRESS IN MODERN BIOMEDICINE, XIAN DAI SHENG WU YI XUE JIN ZHAN BIAN JI BU, CN, vol. 16, no. 7, 1 March 2016 (2016-03-01), CN, pages 1363 - 1365, XP055790961, ISSN: 1673-6273, DOI: 10.13241/j.cnki.pmb.2016.07.038
PARK YUK PHEEL; JIN LINCHUN; BENNETT KATIE B.; WANG DUNRUI; FREDENBURG KRISTIANNA M.; TSENG JENNIFER E.; CHANG LUNG‐JI; HUANG JIAN: "CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma", ORAL ONCOLOGY, ELSEVIER SCIENCE, OXFORD, GB, vol. 78, 20 February 2018 (2018-02-20), GB, pages 145 - 150, XP085353974, ISSN: 1368-8375, DOI: 10.1016/j.oraloncology.2018.01.024
PARK YUK PHEEL; JIN LINCHUN; BENNETT KATIE B.; WANG DUNRUI; FREDENBURG KRISTIANNA M.; TSENG JENNIFER E.; CHANG LUNG‐JI; HUANG JIAN: "CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma", ORAL ONCOLOGY, ELSEVIER SCIENCE, OXFORD, GB, vol. 78, 20 February 2018 (2018-02-20), GB, pages 145 - 150, XP085353974, ISSN: 1368-8375, DOI: 10.1016/j.oraloncology.2018.01.024
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP) (CN)
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