Title:
ANTI-CDH6 ANTIBODY AND ANTI-CDH6 ANTIBODY-DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2018/212136
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: an antibody having an internalization activity of binding to CDH6; an antibody-drug conjugate consisting of the aforesaid antibody and a drug having an antitumor activity; a medicine using the antibody-drug conjugate, said medicine having a therapeutic effect on tumors; a method for treating tumors using the antibody, the antibody-drug conjugate or the medicine; etc. Provided are: an anti-CDH6 antibody having an internalization activity; an antibody-drug conjugate consisting of the aforesaid antibody and a drug having an antitumor activity; and a medicine and a method for treating tumors using the same.
Inventors:
SAITO ATSUKO (JP)
HIRATA TSUYOSHI (JP)
NAKAMURA KENSUKE (JP)
HIRATA TSUYOSHI (JP)
NAKAMURA KENSUKE (JP)
Application Number:
PCT/JP2018/018572
Publication Date:
November 22, 2018
Filing Date:
May 14, 2018
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/13; A61K9/00; A61K31/4745; A61K39/395; A61K47/68; A61P13/12; A61P15/08; A61P35/00; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
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| WO2016024195A1 | 2016-02-18 | |||
| WO2014057687A1 | 2014-04-17 | |||
| WO2014057687A1 | 2014-04-17 | |||
| WO2016024195A1 | 2016-02-18 | |||
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Foreign References:
| US20160297890A1 | 2016-10-13 | |||
| US20160297890A1 | 2016-10-13 |
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CELL DEATH AND DIFFERENTIATION, vol. 15, 2008, pages 751 - 761
MOLECULAR BIOLOGY OF THE CELL, vol. 15, December 2004 (2004-12-01), pages 5268 - 5282
BIO TECHNIQUES, vol. 28, January 2000 (2000-01-01), pages 162 - 165
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MIR LMBUREAU MFGEHL JRANGARA RROUY DCAILLAUD JMDELAERE PBRANELLEC DSCHWARTZ BSCHERMAN D, PROC NATL ACAD SCI USA, vol. 96, no. 8, 13 April 1999 (1999-04-13), pages 4262 - 7
MCMAHON JM1SIGNORI EWELLS KEFAZIO VMWELLS DJ., GENE THER., vol. 8, no. 16, August 2001 (2001-08-01), pages 1264 - 70
PROC. NATL. ACAD. SCI. U.S.A., vol. 81, 1984, pages 6851 - 6855
NATURE, vol. 321, 1986, pages 522 - 525
LARKIN MABLACKSHIELDS GBROWN NPCHENNA RMCGETTIGAN PAMCWILLIAM HVALENTIN FWALLACE IMWILMLOPEZ R: "Clustal W and Clustal X version 2.0", BIOINFORMATICS, vol. 23, no. 21, 2007, pages 2947 - 2948
TOMIZUKA, K. ET AL., NATURE GENETICS, vol. 16, 1997, pages 133 - 143
KUROIWA, Y. ET AL., NUCL. ACIDS RES., vol. 26, 1998, pages 3447 - 3448
YOSHIDA, H. ET AL.: "Animal Cell Technology: Basic and Applied Aspects", vol. 10, 1999, KLUWER ACADEMIC PUBLISHERS, pages: 69 - 73
TOMIZUKA, K. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
WORMSTONE, I. M. ET AL., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 43, no. 7, 2002, pages 2301 - 2308
CARMEN, S. ET AL., BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS, vol. 1, no. 2, 2002, pages 189 - 203
SIRIWARDENA, D. ET AL., OPHTHALMOLOGY, vol. 109, no. 3, 2002, pages 427 - 431
NATURE BIOTECHNOLOGY, vol. 23, no. 9, 2005, pages 1105 - 1116
ANNU. REV. IMMUNOL, vol. 12, 1994, pages 433 - 455
LORI BURTON ET AL., PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 12, 2007, pages 265 - 273
GLUZMAN, Y., CELL, vol. 23, 1981, pages 175 - 182
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
HERMANSON, G.T: "Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS, pages: 56 - 136,456-493
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
"Protein Cell", PHARMACOL REV, vol. 68, January 2016 (2016-01-01), pages 3 - 19
PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
QUEEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
METHODS IN ENZYMOLOGY, vol. 203, 1991, pages 121 - 153
NUC. ACID RES., vol. 35, 2007, pages D301 - D303
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH
See also references of EP 3626825A4
SHIMOYAMA Y ET AL., CANCER RESEARCH, vol. 55, 15 May 1995 (1995-05-15), pages 2206 - 2211
INOUE T ET AL., DEVELOPMENTAL BIOLOGY, 1997, pages 183 - 194
OSTERHOUT J A ET AL., NEURON, vol. 71, 25 August 2011 (2011-08-25), pages 632 - 639
CHO E A ET AL., DEVELOPMENT, vol. 125, 1998, pages 803 - 812
MAH S P ET AL., DEVELOPMENTAL BIOLOGY, vol. 38-53, 2000, pages 223
PAUL R ET AL., CANCER RESEARCH, vol. 2741-2748, 1 July 1997 (1997-07-01), pages 57
SHIMAZUI T ET AL., CANCER, vol. 101, no. 5, 1 September 2004 (2004-09-01), pages 963 - 968
KOEBEL M ET AL., PLOS MEDICINE, vol. 5, no. 12, December 2008 (2008-12-01), pages 1749 - 1760
GUGNONI M ET AL., ONCOGENE, vol. 36, 2017, pages 667 - 677
POLAKIS P., PHARMACOLOGICAL REVIEWS, vol. 68, 2016, pages 3 - 19
PETERS C ET AL., BIOSCIENCE REPORTS, vol. 35, 2015, pages 1 - 20
GOEPPERT B ET AL., EPIGENETICS, vol. 11, no. 11, 2016, pages 780 - 790
YOKOI S ET AL., AMERICAN JOURNAL OF PATHOLOGY, vol. 161, no. 1, 2002, pages 207 - 216
CELL DEATH AND DIFFERENTIATION, vol. 15, 2008, pages 751 - 761
MOLECULAR BIOLOGY OF THE CELL, vol. 15, December 2004 (2004-12-01), pages 5268 - 5282
BIO TECHNIQUES, vol. 28, January 2000 (2000-01-01), pages 162 - 165
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
URLAUB, G.CHASIN, L. A., PROC. NATL. ACAD. SCI. U.S.A., vol. 77, 1980, pages 4126 - 4220
AIHARA HMIYAZAKI J, NAT BIOTECHNOL., vol. 16, no. 9, September 1998 (1998-09-01), pages 867 - 70
MIR LMBUREAU MFGEHL JRANGARA RROUY DCAILLAUD JMDELAERE PBRANELLEC DSCHWARTZ BSCHERMAN D, PROC NATL ACAD SCI USA, vol. 96, no. 8, 13 April 1999 (1999-04-13), pages 4262 - 7
MCMAHON JM1SIGNORI EWELLS KEFAZIO VMWELLS DJ., GENE THER., vol. 8, no. 16, August 2001 (2001-08-01), pages 1264 - 70
PROC. NATL. ACAD. SCI. U.S.A., vol. 81, 1984, pages 6851 - 6855
NATURE, vol. 321, 1986, pages 522 - 525
LARKIN MABLACKSHIELDS GBROWN NPCHENNA RMCGETTIGAN PAMCWILLIAM HVALENTIN FWALLACE IMWILMLOPEZ R: "Clustal W and Clustal X version 2.0", BIOINFORMATICS, vol. 23, no. 21, 2007, pages 2947 - 2948
TOMIZUKA, K. ET AL., NATURE GENETICS, vol. 16, 1997, pages 133 - 143
KUROIWA, Y. ET AL., NUCL. ACIDS RES., vol. 26, 1998, pages 3447 - 3448
YOSHIDA, H. ET AL.: "Animal Cell Technology: Basic and Applied Aspects", vol. 10, 1999, KLUWER ACADEMIC PUBLISHERS, pages: 69 - 73
TOMIZUKA, K. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
WORMSTONE, I. M. ET AL., INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 43, no. 7, 2002, pages 2301 - 2308
CARMEN, S. ET AL., BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS, vol. 1, no. 2, 2002, pages 189 - 203
SIRIWARDENA, D. ET AL., OPHTHALMOLOGY, vol. 109, no. 3, 2002, pages 427 - 431
NATURE BIOTECHNOLOGY, vol. 23, no. 9, 2005, pages 1105 - 1116
ANNU. REV. IMMUNOL, vol. 12, 1994, pages 433 - 455
LORI BURTON ET AL., PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 12, 2007, pages 265 - 273
GLUZMAN, Y., CELL, vol. 23, 1981, pages 175 - 182
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
HERMANSON, G.T: "Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS, pages: 56 - 136,456-493
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
"Protein Cell", PHARMACOL REV, vol. 68, January 2016 (2016-01-01), pages 3 - 19
PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
QUEEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
METHODS IN ENZYMOLOGY, vol. 203, 1991, pages 121 - 153
NUC. ACID RES., vol. 35, 2007, pages D301 - D303
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE NATIONAL INSTITUTES OF HEALTH
See also references of EP 3626825A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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