Title:
(ANTI-CDH6 ANTIBODY)-(PYRROLOBENZODIAZEPINE DERIVATIVE) CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2020/100954
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: an antibody which can bind specifically to CDH6 and has a high internalization activity; an antibody-drug conjugate which contains the antibody and has a high anti-tumor activity; a medicine which is prepared using the antibody-drug conjugate and has a therapeutic effect on tumors; a method for treating a tumor using the antibody, the antibody-drug conjugate or the medicine; and others. According to the present invention, there are provided: an anti-CDH6 antibody which has an internalization activity; an (anti-CDH6 antibody)-drug conjugate which comprises the anti-CDH6 antibody and a novel PBD derivative bonded to each other and has a high anti-tumor activity; and a medicine and a method for treating a tumor, in each of which the anti-CDH6 antibody or the (anti-CDH6 antibody)-drug conjugate is used.
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Inventors:
SAITO ATSUKO (JP)
HARADA NAOYA (JP)
YONEDA KOZO (JP)
HAYAKAWA ICHIRO (JP)
MEGURO MASAKI (JP)
DOI FUMINAO (JP)
HARADA NAOYA (JP)
YONEDA KOZO (JP)
HAYAKAWA ICHIRO (JP)
MEGURO MASAKI (JP)
DOI FUMINAO (JP)
Application Number:
PCT/JP2019/044588
Publication Date:
May 22, 2020
Filing Date:
November 13, 2019
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
C12N15/13; A61K39/395; A61K47/68; A61P35/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/63; C12P21/08
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| WO2019065964A1 | 2019-04-04 | |||
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| WO2014057687A1 | 2014-04-17 | |||
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ANGEW. CHEM. INT. ED., vol. 55, 2016, pages 2361 - 2367
BIOTECHNOL. PROG., vol. 28, 2012, pages 608 - 622
SANGLIER-CIANFERANI, S., ANAL. CHEM., vol. 85, 2013, pages 715 - 736
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PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
QUEEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
METHODS IN ENZYMOLOGY, vol. 203, 1991, pages 121 - 153
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See also references of EP 3882349A4
SHIMOYAMA Y ET AL., CANCER RESEARCH, vol. 2206-2211, 15 May 1995 (1995-05-15), pages 55
INOUE T ET AL., DEVELOPMENTAL BIOLOGY, 1997, pages 183 - 194
OSTERHOUT J A ET AL., NEURON, vol. 632-639, 25 August 2011 (2011-08-25), pages 71
CHO E A ET AL., DEVELOPMENT, vol. 803-812, 1998, pages 125
MAH S P ET AL., DEVELOPMENTAL BIOLOGY, vol. 38-53, 2000, pages 223
PAUL R ET AL., CANCER RESEARCH, vol. 2741-2748, 1997, pages 57
SHIMAZUI T ET AL., CANCER, vol. 101, no. 5, 1 September 2004 (2004-09-01), pages 963 - 968
KOEBEL M ET AL., PLOS MEDICINE, vol. 5, no. 12, December 2008 (2008-12-01), pages 1749 - 1760
GUGNONI M ET AL., ONCOGENE, vol. 36, 2017, pages 667 - 677
POLAKIS P., PHARMACOLOGICAL REVIEWS, vol. 68, 2016, pages 3 - 19
PETERS C ET AL., BIOSCIENCE REPORTS, vol. 35, 2015, pages 1 - 20
GOEPPERT B ET AL., EPIGENETICS, vol. 11, no. 11, 2016, pages 780 - 790
YOKOI S ET AL., AMERICAN JOURNAL OF PATHOLOGY, vol. 161, no. 1, 2002, pages 207 - 216
JULIA MANTAJ ET AL., ANGEWANDTE CHEMIE INTERNATIONL EDITION, vol. 55, 2016, pages 2 - 29
DYEISON ANTONOW, CHEMICAL REVIEWS, vol. 111, 2010, pages 2815 - 2864
ACCOUNTS OF CHEMICAL RESEARCH, vol. 19, 1986, pages 230 - 11
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, 1992, pages 4939
JOURNAL OF ORGANIC CHEMISTRY, vol. 61, 1996, pages 8141
CELL DEATH AND DIFFERENTIATION, vol. 15, 2008, pages 751 - 761
MOLECULAR BIOLOGY OF THE CELL, vol. 15, December 2004 (2004-12-01), pages 5268 - 5282
BIO TECHNIQUES, vol. 28, January 2000 (2000-01-01), pages 162 - 165
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
URLAUB, G.CHASIN, L. A., PROC. NATL. ACAD. SCI. U.S.A., vol. 77, 1980, pages 4126 - 4220
AIHARA HMIYAZAKI, J. NAT BIOTECHNOL., vol. 16, no. 9, September 1998 (1998-09-01), pages 867 - 70
MIR LMBUREAU MFGEHL JRANGARA RROUY DCAILLAUD JMDELAERE PBRANELLEC DSCHWARTZ BSCHERMAN D, PROC NATL ACAD SCI USA., vol. 96, no. 8, 13 April 1999 (1999-04-13), pages 4262 - 7
MCMAHON JM1SIGNORI EWELLS KEFAZIO VMWELLS DJ., GENE THER, vol. 8, no. 16, August 2001 (2001-08-01), pages 1264 - 70
PROC. NATL. ACAD. SCI. U.S.A., vol. 81, 1984, pages 6851 - 6855
NATURE, vol. 321, 1986, pages 522 - 525
TOMIZUKA, K. ET AL., NATURE GENETICS, vol. 16, 1997, pages 133 - 143
KUROIWA, Y. ET AL., NUCL. ACIDS RES., vol. 26, 1998, pages 3447 - 3448
YOSHIDA, H. ET AL.: "Animal Cell Technology: Basic and Applied Aspects", vol. 10, 1999, KLUWER ACADEMIC PUBLISHERS, pages: 69 - 73
TOMIZUKA, K. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 722 - 727
WORMSTONE, I. M. ET AL., INVESTIGATIVE OPHTHALMOLOGY VISUAL SCIENCE, vol. 43, no. 7, 2002, pages 2301 - 2308
CARMEN, S. ET AL., BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS, vol. 1, no. 2, 2002, pages 189 - 203
SIRIWARDENA, D. ET AL., OPHTHALMOLOGY, vol. 109, no. 3, 2002, pages 427 - 431
NATURE BIOTECHNOLOGY, vol. 23, no. 9, 2005, pages 1105 - 1116
ANNU. REV. IMMUNOL, vol. 12, 1994, pages 433 - 455
LORI BURTON ET AL., PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, vol. 12, 2007, pages 265 - 273
GLUZMAN, Y., CELL, vol. 23, 1981, pages 175 - 182
JOURNAL OF CHROMATOGRAPHY A, vol. 705, 1995, pages 129 - 134
ANALYTICAL BIOCHEMISTRY, vol. 360, 2007, pages 75 - 83
JOURNAL OF VIROLOGY, vol. 75, no. 24, 15 December 2001 (2001-12-15), pages 12161 - 12168
EDELMAN ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 63, 15 May 1969 (1969-05-15), pages 78 - 85
"Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS
"Antibodies: A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY
ACS CHEMICAL BIOLOGY, vol. 7, 2012, pages 110
ACS MEDICINAL CHEMISTRY LETTERS, vol. 7, 2016, pages 1005
BIOCONJUGATE CHEMISTRY, vol. 26, 2015, pages 2233
ANGEW. CHEM. INT. ED., vol. 55, 2016, pages 2361 - 2367
BIOTECHNOL. PROG., vol. 28, 2012, pages 608 - 622
SANGLIER-CIANFERANI, S., ANAL. CHEM., vol. 85, 2013, pages 715 - 736
J. ORG CHEM., vol. 74, no. 5, 2009, pages 2210 - 2212
HELV. CHIM. ACTA, vol. 95, 2012, pages 1928 - 1936
J. AM. CHEM. SOC., vol. 134, 2012, pages 12308 - 12318
J. AM. CHEM. SOC., vol. 126, 2004, pages 15046 - 15047
PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
QUEEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 10029 - 10033
METHODS IN ENZYMOLOGY, vol. 203, 1991, pages 121 - 153
JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, 2004, pages 1161
TETRAHEDRON LETTERS, vol. 53, 2012, pages 3847
TETRAHEDRON, vol. 51, 1995, pages 5617
See also references of EP 3882349A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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