Title:
ANTI-CEA ANTIBODY AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/259550
Kind Code:
A1
Abstract:
Provided is an anti-CEA antibody comprising a heavy chain variable region and a light chain variable region, a drug conjugate thereof, and a composition containing the anti-CEA antibody or the drug conjugate thereof, and an application thereof as a drug.
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Inventors:
YING HUA (CN)
MAO LANGYONG (CN)
ZHANG LING (CN)
GE HU (CN)
TAO WEIKANG (CN)
MAO LANGYONG (CN)
ZHANG LING (CN)
GE HU (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2020/097984
Publication Date:
December 30, 2020
Filing Date:
June 24, 2020
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/30; A61K39/395; A61K47/68; A61P35/00; C07K19/00; C12N15/13; C12N15/63; G01N33/50
Domestic Patent References:
| WO2005086875A2 | 2005-09-22 | |||
| WO1999043817A1 | 1999-09-02 | |||
| WO2004032962A1 | 2004-04-22 | |||
| WO2005086875A2 | 2005-09-22 | |||
| WO2012117002A1 | 2012-09-07 | |||
| WO2016127790A1 | 2016-08-18 |
Foreign References:
| CN102741293A | 2012-10-17 | |||
| CN101607985A | 2009-12-23 | |||
| CN103403029A | 2013-11-20 | |||
| CN201910560329A | 2019-06-26 | |||
| CN101573384A | 2009-11-04 | |||
| US4683195A | 1987-07-28 |
Other References:
THOMPSON JA, J CLIN LAB ANAL, vol. 5, 1991, pages 344 - 366
MARSHALL J., SEMIN ONCOL., vol. 30, 2003, pages 30 - 6
NAP ET AL., TUMOUR BIOL, vol. 9, no. 2-3, 1988, pages 145 - 53
NAP ET AL., CANCER RES, vol. 52, no. 8, 1992, pages 2329 - 2339
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT, EA ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG., vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES, vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS, CANCER IMMUNOL, 2001
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC MP, IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, MP, DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
MADDEN, TL ET AL., METH. ENZYMOL., vol. 266, 1996, pages 131 - 141
STAHLI ET AL., METHODS IN ENZYMOLOGY, vol. 9, 1983, pages 242 - 253
KIRKLAND ET AL., J. IMMUNOL., vol. 137, 1986, pages 3614 - 3619
MOREL ET AL., MOLEC. IMMUNOL., vol. 25, 1988, pages 7 - 15
CHEUNG ET AL., VIROLOGY, vol. 176, 1990, pages 546 - 552
MOLDENHAUER ET AL., SCAND. J. IMMUNOL., vol. 32, 1990, pages 77 - 82
"The Immunoglobulin Facts Book", 2001
MULLIS ET AL., COLD SPRING HARBOR SYMP. OUANT. BIOL., vol. 51, 1987, pages 263
ALTSCHUL, SF ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
GISH, W. ET AL., NATURE GENET, vol. 3, 1993, pages 266 - 272
ALTSCHUL, SF ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ZHANG ET AL., GENOME RES, vol. 7, 1997, pages 649 - 656
"PCR TECHNOLOGY", 1989, STOCKTON PRESS
SAMBROOK ET AL.: "Antibodies: Laboratory Manual, and Molecular Cloning", COLD SPRING HARBOR LABORATORY
See also references of EP 3992211A4
MARSHALL J., SEMIN ONCOL., vol. 30, 2003, pages 30 - 6
NAP ET AL., TUMOUR BIOL, vol. 9, no. 2-3, 1988, pages 145 - 53
NAP ET AL., CANCER RES, vol. 52, no. 8, 1992, pages 2329 - 2339
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT, EA ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
HOLLIGER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
ALFTHAN ET AL., PROTEIN ENG., vol. 8, 1995, pages 725 - 731
CHOI ET AL., EUR. J. IMMUNOL., vol. 31, 2001, pages 94 - 106
HU ET AL., CANCER RES, vol. 56, 1996, pages 3055 - 3061
KIPRIYANOV ET AL., J. MOL. BIOL., vol. 293, 1999, pages 41 - 56
ROOVERS, CANCER IMMUNOL, 2001
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC MP, IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, MP, DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
MADDEN, TL ET AL., METH. ENZYMOL., vol. 266, 1996, pages 131 - 141
STAHLI ET AL., METHODS IN ENZYMOLOGY, vol. 9, 1983, pages 242 - 253
KIRKLAND ET AL., J. IMMUNOL., vol. 137, 1986, pages 3614 - 3619
MOREL ET AL., MOLEC. IMMUNOL., vol. 25, 1988, pages 7 - 15
CHEUNG ET AL., VIROLOGY, vol. 176, 1990, pages 546 - 552
MOLDENHAUER ET AL., SCAND. J. IMMUNOL., vol. 32, 1990, pages 77 - 82
"The Immunoglobulin Facts Book", 2001
MULLIS ET AL., COLD SPRING HARBOR SYMP. OUANT. BIOL., vol. 51, 1987, pages 263
ALTSCHUL, SF ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
GISH, W. ET AL., NATURE GENET, vol. 3, 1993, pages 266 - 272
ALTSCHUL, SF ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
ZHANG ET AL., GENOME RES, vol. 7, 1997, pages 649 - 656
"PCR TECHNOLOGY", 1989, STOCKTON PRESS
SAMBROOK ET AL.: "Antibodies: Laboratory Manual, and Molecular Cloning", COLD SPRING HARBOR LABORATORY
See also references of EP 3992211A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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