Title:
ANTI-CHYMASE APTAMER AND USE FOR SAME
Document Type and Number:
WIPO Patent Application WO/2019/107532
Kind Code:
A1
Abstract:
The present invention provides an aptamer that binds to chymase and includes a consensus sequence that is represented by UAACR1N1R2GGGG (provided that the uracil may be thymine). (In the formula, R1 and R2 are arbitrary single bases, and N1 is 3–30 bases).
Inventors:
YAMAZAKI SATOKO (JP)
NONAKA YOSUKE (JP)
NAKAMURA YOSHIKAZU (JP)
MURAGUCHI MASAHIRO (JP)
MURATA KAORI (JP)
NONAKA YOSUKE (JP)
NAKAMURA YOSHIKAZU (JP)
MURAGUCHI MASAHIRO (JP)
MURATA KAORI (JP)
Application Number:
PCT/JP2018/044132
Publication Date:
June 06, 2019
Filing Date:
November 30, 2018
Export Citation:
Assignee:
RIBOMIC INC (JP)
International Classes:
C12N15/115; A61K31/7088; A61K47/51; A61K47/55; A61K49/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/08; A61P19/10; A61P21/00; A61P25/00; A61P27/02; A61P35/00; A61P37/08; A61P43/00; C12Q1/6806
Domestic Patent References:
| WO2010143714A1 | 2010-12-16 | |||
| WO1991019813A1 | 1991-12-26 | |||
| WO1994008050A1 | 1994-04-14 | |||
| WO1995007364A1 | 1995-03-16 | |||
| WO2010143714A1 | 2010-12-16 |
Foreign References:
| US6500835B2 | 2002-12-31 | |||
| US5660985A | 1997-08-26 | |||
| JP2017230503A | 2017-11-30 |
Other References:
JIN, D. ET AL.: "A chymase inhibitory RNA aptamer improves cardiac function and survival after myocardial infarction", MOLECULAR THERAPY - NUCLEIC ACIDS, vol. 14, 13 November 2018 (2018-11-13), pages 41 - 51, XP055616361, DOI: 10.1016/j.omtn.2018.11.001
JIN, DENAN ET AL.: "Chymase inhibition by novel RNA aptamers and improvement effect on cardiac function and survival rate after myocardial infarction", PROGRAMS AND ABSTRACTS OF THE 23TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR PROTEASES IN PATHOPHYSIOLOGY, 30 July 2018 (2018-07-30), pages 40, XP009521235
SPROAT ET AL., NUCLE. ACID. RES., vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
"Nucleic Acid", vol. 2, HIROKAWA PUBLISHING COMPANY, article "Synthesis and Analysis of Nucleic Acid"
ELLINGTONSZOSTAK, NATURE, vol. 346, 1990, pages 818 - 822
TUERK ET AL., SCIENCE, vol. 249, 1990, pages 505 - 510
M. ZUKER, NUCLEIC ACIDS RES., vol. 31, no. 13, 2003, pages 3406 - 3415
JIN, DENAN ET AL.: "Chymase inhibition by novel RNA aptamers and improvement effect on cardiac function and survival rate after myocardial infarction", PROGRAMS AND ABSTRACTS OF THE 23TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR PROTEASES IN PATHOPHYSIOLOGY, 30 July 2018 (2018-07-30), pages 40, XP009521235
SPROAT ET AL., NUCLE. ACID. RES., vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
"Nucleic Acid", vol. 2, HIROKAWA PUBLISHING COMPANY, article "Synthesis and Analysis of Nucleic Acid"
ELLINGTONSZOSTAK, NATURE, vol. 346, 1990, pages 818 - 822
TUERK ET AL., SCIENCE, vol. 249, 1990, pages 505 - 510
M. ZUKER, NUCLEIC ACIDS RES., vol. 31, no. 13, 2003, pages 3406 - 3415
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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