Title:
ANTI-CLDN-5 ANTIBODY, AND DRUG CONTAINING SAID ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2018/207638
Kind Code:
A1
Abstract:
The problem of providing a novel molecule having high specificity to CLDN-5 and capable of recognizing an extracellular domain of CLDN-5 can be solved by an antibody capable of specifically recognizing the three-dimensional structure or the primary structure of an extracellular domain of Claudin-5 protein.
Inventors:
KONDOH MASUO (JP)
YAGI KIYOHITO (JP)
DOI TAKEFUMI (JP)
OKADA YOSHIAKI (JP)
HASHIMOTO YOSUKE (JP)
SAWASAKI TATSUYA (JP)
TAKEDA HIROYUKI (JP)
ENDO KOHKI (JP)
TAMURA MAKI (JP)
YAGI KIYOHITO (JP)
DOI TAKEFUMI (JP)
OKADA YOSHIAKI (JP)
HASHIMOTO YOSUKE (JP)
SAWASAKI TATSUYA (JP)
TAKEDA HIROYUKI (JP)
ENDO KOHKI (JP)
TAMURA MAKI (JP)
Application Number:
PCT/JP2018/016975
Publication Date:
November 15, 2018
Filing Date:
April 26, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
UNIV NAT CORP EHIME UNIV (JP)
FUJIFILM WAKO PURE CHEMICAL CORP (JP)
UNIV NAT CORP EHIME UNIV (JP)
FUJIFILM WAKO PURE CHEMICAL CORP (JP)
International Classes:
C07K16/28; A61K39/395; A61K47/42; A61K47/68; A61P43/00; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N5/12; C12N15/13
Domestic Patent References:
WO2009028663A1 | 2009-03-05 | |||
WO2008114733A1 | 2008-09-25 | |||
WO2016088689A1 | 2016-06-09 |
Foreign References:
US20110064792A1 | 2011-03-17 | |||
JP2016525558A | 2016-08-25 | |||
JP2016047845A | 2016-04-07 | |||
JP2003524384A | 2003-08-19 |
Other References:
LIAO, ZHUANGBIN ET AL.: "Specific binding of a mutated fragment ofClostridium perfringensenterotoxin to endothelial claudin-5 and its modulation of cerebral vascular permeability", NEUROSCIENCE, vol. 327, 13 April 2016 (2016-04-13), pages 53 - 63, XP029535193
NITTA, TAKEHIRO: "Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice", J. CELL BIOL., vol. 161, no. 3, 12 May 2003 (2003-05-12), pages 653 - 660, XP002472300
ESCUDERO-ESPARZA, ASTRID ET AL.: "Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 31, no. 43, 2012, pages 1 - 18, XP021117275
PROTZE, JONAS ET AL.: "Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5", CELL. MOL. LIFE SCI., vol. 72, 2015, pages 1417 - 1432, XP035471604
MATTHEW CAMPBELLANNA-SOPHIA KIANGPAUL F. KENNACHRISTIAN KERSKENSCHRISTOPH BLAULAURENCE O'DWYERAMANDA TIVNANJULIE ANNE KELLYBRENDA : "RNAi-mediated reversible opening of the blood-brain barrier", THE JOURNAL OF GENE MEDICINE, vol. 10, 2008, pages 930 - 947, XP002536283, DOI: 10.1002/JGM.1211
CHRISTIAN STAATCAROLINE COISNESEBASTIAN DABROWSKISVETLANA M. STAMATOVICANUSKA V. ANDJELKOVICHARTWIG WOLBURGBRITTA ENGELHARDTINGOLF: "Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers", BIOMATERIALS, vol. 54, 2015, pages 9 - 20, XP055343621, DOI: 10.1016/j.biomaterials.2015.03.007
JONAS PROTZEMIRIAM EICHNERANNA PIONTEKSTEFAN DINTERJANROSSAKINGA GRAZYNA BLECHARZPETER VAJKOCZYJOERG PIONTEKGERD KRAUSE: "Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5", CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 72, 2015, pages 1417 - 1432, XP035471604, DOI: 10.1007/s00018-014-1761-6
KARLIN SALTSCHUL SF: "Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes", PROC NATL ACAD SCI USA, vol. 87, 1990, pages 2264 - 2268, XP001030853, DOI: 10.1073/pnas.87.6.2264
KARLINSALTSCHUL SF: "Applications and statistics for multiple high-scoring segments in molecular sequences", PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873 - 7, XP001030852, DOI: 10.1073/pnas.90.12.5873
"Current protocols in Molecular Biology", 1987, JOHN WILEY AND SONS
See also references of EP 3623384A4
NITTA, TAKEHIRO: "Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice", J. CELL BIOL., vol. 161, no. 3, 12 May 2003 (2003-05-12), pages 653 - 660, XP002472300
ESCUDERO-ESPARZA, ASTRID ET AL.: "Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 31, no. 43, 2012, pages 1 - 18, XP021117275
PROTZE, JONAS ET AL.: "Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5", CELL. MOL. LIFE SCI., vol. 72, 2015, pages 1417 - 1432, XP035471604
MATTHEW CAMPBELLANNA-SOPHIA KIANGPAUL F. KENNACHRISTIAN KERSKENSCHRISTOPH BLAULAURENCE O'DWYERAMANDA TIVNANJULIE ANNE KELLYBRENDA : "RNAi-mediated reversible opening of the blood-brain barrier", THE JOURNAL OF GENE MEDICINE, vol. 10, 2008, pages 930 - 947, XP002536283, DOI: 10.1002/JGM.1211
CHRISTIAN STAATCAROLINE COISNESEBASTIAN DABROWSKISVETLANA M. STAMATOVICANUSKA V. ANDJELKOVICHARTWIG WOLBURGBRITTA ENGELHARDTINGOLF: "Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers", BIOMATERIALS, vol. 54, 2015, pages 9 - 20, XP055343621, DOI: 10.1016/j.biomaterials.2015.03.007
JONAS PROTZEMIRIAM EICHNERANNA PIONTEKSTEFAN DINTERJANROSSAKINGA GRAZYNA BLECHARZPETER VAJKOCZYJOERG PIONTEKGERD KRAUSE: "Directed structural modification of Clostridium perfringens enterotoxin to enhance binding to claudin-5", CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 72, 2015, pages 1417 - 1432, XP035471604, DOI: 10.1007/s00018-014-1761-6
KARLIN SALTSCHUL SF: "Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes", PROC NATL ACAD SCI USA, vol. 87, 1990, pages 2264 - 2268, XP001030853, DOI: 10.1073/pnas.87.6.2264
KARLINSALTSCHUL SF: "Applications and statistics for multiple high-scoring segments in molecular sequences", PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873 - 7, XP001030852, DOI: 10.1073/pnas.90.12.5873
"Current protocols in Molecular Biology", 1987, JOHN WILEY AND SONS
See also references of EP 3623384A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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