Title:
ANTI-COMPLEMENT COMPONENT ANTIBODIES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2019/198807
Kind Code:
A1
Abstract:
The invention provides anti-complement component antibodies such as anti-C1s antibodies and anti-C1r antibodies, and methods of using the same. The invention also provides pharmaceutical formulations comprising the antibodies, and methods of treating an individual having a complement-mediated disease or disorder comprising administering the antibody to the individual. The binding specificity and C1q displacement function of the anti-C1s antibodies and anti-C1r antibodies are evaluated. Time dependent complement neutralization function and binding to native and truncated C1s or C1r proteins are also shown for the antibodies.
Inventors:
FUKUZAWA TAKU (JP)
HARAYA KENTA (JP)
HO WEI SHIONG ADRIAN (SG)
TAKAHASHI NORIYUKI (SG)
MURAOKA MASARU (JP)
HARAYA KENTA (JP)
HO WEI SHIONG ADRIAN (SG)
TAKAHASHI NORIYUKI (SG)
MURAOKA MASARU (JP)
Application Number:
PCT/JP2019/015919
Publication Date:
October 17, 2019
Filing Date:
April 12, 2019
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/18; A61K39/395
Domestic Patent References:
| WO2013192240A2 | 2013-12-27 | |||
| WO2017091719A1 | 2017-06-01 | |||
| WO2016164358A1 | 2016-10-13 | |||
| WO2010136831A1 | 2010-12-02 |
Foreign References:
| US20160053023A1 | 2016-02-25 | |||
| US20160326237A1 | 2016-11-10 |
Other References:
BALLY, ISABELLE ET AL.: "Identification of the C1q-binding Sites of Human C1r and C1s", J.BIOL.CHEM., vol. 284, no. 29, May 2009 (2009-05-01), pages 19340 - 19348, XP055644666
TSENG, YIOU ET AL.: "PROBING THE STRUCTURE OF C1 WITH AN ANTI-Cls MONOCLONAL ANTIBODY: THE POSSIBLE EXISTENCE OF TWO FORMS OF C1 IN SOLUTION", MOLECULAR IMMUNOLOGY, vol. 34, no. 8 / 9, 1997, pages 671 - 679, XP055246713
ALMITAIRI, JAMAL O. M. ET AL.: "Structure of the C1r-C1s interaction of the C1 complex of complement activation", PNAS, vol. 115, no. 4, 23 January 2018 (2018-01-23), pages 768 - 773, XP055644672
See also references of EP 3774892A4
TSENG, YIOU ET AL.: "PROBING THE STRUCTURE OF C1 WITH AN ANTI-Cls MONOCLONAL ANTIBODY: THE POSSIBLE EXISTENCE OF TWO FORMS OF C1 IN SOLUTION", MOLECULAR IMMUNOLOGY, vol. 34, no. 8 / 9, 1997, pages 671 - 679, XP055246713
ALMITAIRI, JAMAL O. M. ET AL.: "Structure of the C1r-C1s interaction of the C1 complex of complement activation", PNAS, vol. 115, no. 4, 23 January 2018 (2018-01-23), pages 768 - 773, XP055644672
See also references of EP 3774892A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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