Title:
ANTI-CRR2 ANTIBODIES AND METHODS OF USE THEREFOR
Document Type and Number:
WIPO Patent Application WO2000005265
Kind Code:
A3
Abstract:
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor (2) (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
Inventors:
LAROSA GREGORY J (US)
HORVATH CHRISTOPHER (US)
NEWMAN WALTER (US)
HORVATH CHRISTOPHER (US)
NEWMAN WALTER (US)
Application Number:
PCT/US1999/016452
Publication Date:
April 27, 2000
Filing Date:
July 22, 1999
Export Citation:
Assignee:
LEUKOSITE INC (US)
LAROSA GREGORY J (US)
HORVATH CHRISTOPHER (US)
NEWMAN WALTER (US)
LAROSA GREGORY J (US)
HORVATH CHRISTOPHER (US)
NEWMAN WALTER (US)
International Classes:
A61K39/395; A61P9/10; A61P29/00; G01N33/53; A61P31/18; A61P37/02; A61P43/00; C07K16/00; C07K16/28; C12N5/10; C12N15/02; C12N15/09; C12P21/08; C12Q1/02; G01N33/566; G01N33/577; C12R1/91; (IPC1-7): C07K16/28; G01N33/53; A61K39/395
Domestic Patent References:
| WO1997031949A1 | 1997-09-04 | |||
| WO1995019436A1 | 1995-07-20 |
Other References:
FRADE J M R ET AL: "The amino-terminal domain of the CCR2 chemokine receptor acts a coreceptor for HIV-1 infection.", JOURNAL OF CLINICAL INVESTIGATION, (1997 AUG 1) 100 (3) 497-502., XP002099012
FRADE J M ET AL: "Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells.", JOURNAL OF IMMUNOLOGY, (1997 DEC 1) 159 (11) 5576-84., XP002126697
FRADE J M ET AL: "Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells.", JOURNAL OF IMMUNOLOGY, (1997 DEC 1) 159 (11) 5576-84., XP002126697
Download PDF: