Title:
ANTI-DENGUE VIRUS ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/025546
Kind Code:
A3
Abstract:
The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.
Inventors:
SASISEKHARAN RAM (US)
ROBINSON LUKE NATHANIEL (US)
THARAKARAMAN KANNAN (US)
ROBINSON LUKE NATHANIEL (US)
THARAKARAMAN KANNAN (US)
Application Number:
PCT/US2013/052062
Publication Date:
April 17, 2014
Filing Date:
July 25, 2013
Export Citation:
Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
A61K39/00; A61K39/12; A61K39/395; A61K39/42
Domestic Patent References:
| WO2010093335A1 | 2010-08-19 | |||
| WO2013089647A1 | 2013-06-20 |
Foreign References:
| US20050147614A1 | 2005-07-07 | |||
| US20110008256A1 | 2011-01-13 | |||
| US20090312190A1 | 2009-12-17 | |||
| US20110212105A1 | 2011-09-01 |
Other References:
COCKBUM ET AL.: "Mechanism of Dengue Virus Broad Cross-Neutralization by a Monoclonal Antibody", STRUCTURE, vol. 20, 8 February 2012 (2012-02-08), pages 303 - 314, XP028414368
DATABASE PDB [online] 21 November 2013 (2013-11-21), "CHAIN A, CRYSTAL STRUCTURE OF THE DENGUE VIRUS SEROTYPE 4 ENVELOPE PROTEIN DOMAIN III IN COMPLEX WITH THE VARIABLE DOMAINS OF MAB 4E11.", XP055190917, accession no. NCBI Database accession no. 3UYP_A
BEDOUELLE ET AL.: "Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus", FEBS JOURNAL, vol. 273, 2006, pages 34 - 46, XP055183465
DATABASE PDB [online] 21 November 2013 (2013-11-21), "CHAIN A, CRYSTAL STRUCTURE OF THE DENGUE VIRUS SEROTYPE 4 ENVELOPE PROTEIN DOMAIN III IN COMPLEX WITH THE VARIABLE DOMAINS OF MAB 4E11.", XP055190917, accession no. NCBI Database accession no. 3UYP_A
BEDOUELLE ET AL.: "Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus", FEBS JOURNAL, vol. 273, 2006, pages 34 - 46, XP055183465
Attorney, Agent or Firm:
JARRELL, Brenda, Herschbach et al. (Hall & Stewart LLPTwo International Plac, Boston MA, US)
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