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Title:
ANTI-DIARRHEA FORMULATION WHICH AVOIDS ANTIMICROBIAL RESISTANCE
Document Type and Number:
WIPO Patent Application WO/2016/032944
Kind Code:
A4
Abstract:
An oral formulation of bromelain effective to treat and prevent diarrhea caused by pathogenic microbes. This formulation does not kill pathogenic microbes, and thus does not facilitate the proliferation of anti-microbial resistant organisms. The invention entails formulating an aqueous oral suspension of bromelain, Blanose sodium carboxymethyl cellulose, citric acid anhydrous, Epikuron 135F lecithin oil and ethylenedinitrilotetraacetic acid, disodium salt dihydrate ("EDTA").

Inventors:
MYNOTT, Tracey, L. (433 Logan Road, Stones CornerBrisbane, QLD 4120, 4120, AU)
WALSH, John (Sidney, AU)
Application Number:
US2015/046509
Publication Date:
March 03, 2016
Filing Date:
August 24, 2015
Export Citation:
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Assignee:
ANATARA LIFESCIENCES LIMITED (433 Logan Road, Stones CornerBrisbane, QLD 4120, 4120, AU)
PHARMACEUTICAL PATENT ATTONREYS, LLC (55 Madison Avenue, 4th FloorMorristown, NJ, 07960, US)
International Classes:
A23K1/165
Attorney, Agent or Firm:
POHL, J. Mark (Pharmaceutical Patent Attorneys, LLC55 Madison Ave,4th Floo, Morristown NJ, 07960, US)
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Claims:
AMENDED CLAIMS

received by the International Bureau on 10 March 2016 (10.03.2016)

1. An oral veterinary formulation comprising an anti-diarrhea effective amount of bromelain, substantially free of enteric polymer.

2. An oral veterinary formulation comprising an anti-diarrhea effective amount of bromelain, substantially free of pthaiate.

3. The oral veterinary formulation of claim 2, wherein said ph thai ate comprises cellulose acetate phthaiate.

4. An oral veterinary formulation comprising an anti- diarrhea effective amount of bromelain, and chelating agent,

5. The oral veterinary formulation of claim 4, wherein the chelating agent comprises EDTA.

6. An oral veterinary formulation comprising an anti- diarrhea effective amount of bromelain and an emulsifier in an amount effective to improve the solubility of said bromelain in water.

7. The oral veterinary formulation of claim 6, said emulsifier comprising lecithin.

8. The oral veterinary formulation of claim 7, further comprising citric acid.

9. An anti-diarrheal oral dosage form comprising an anti-diarrheal effective amount of carboxymethylcellulose.

10. The dosage form of claim 9, further comprising bromelain.

1 1. The dosage form of claim 10, where the oral dosage form is a drink or oral drench.

12. The dosage form of claim 30, where the dosage form is a veterinary dosage form.

13. A method for preventing the proliferation of anti-microbial resistant pathogenic gut microbes in humans, animals or fish, comprising; (a) identifying a human, animal or fish vulnerable to infection by pathogenic gut microbes, and then (b) orally administering to said human, animal or fish an amount of bromelain effective to prevent said human, animal or fish from becoming diarrheal from said pathogenic gut microbes, whereby said human, animal or fish is no longer vulnerable to infection by said pathogenic gut microbes, whereby said human, animal or fish is not administered an anti- microbial effective amount of an anti-microbial to treat or prevent diarrhea by said pathogenic gut bacteria.

14. A method for preventing the proliferation of pathogenic gut microbes in humans, animals or fish, comprising: (a) identifying a human, animal or fish vulnerable to infection by pathogenic gut microbes, and then (b) orally administering to said human, animal or fish an amount of bromelain effective to prevent said human, animal or fish from becoming sick from said pathogenic gut microbes, whereby said human, animal or fish is no longer vulnerable to infection by said pathogenic gut microbes, whereby said human, animal or fish is not administered an anti- microbial effective amount of an anti-microbial to treat or prevent said infection by said pathogenic gut microbes.

15. The dosage form of Claim 2, where the dosage form is animal feed.

16. The use of the oral veterinary formulation of Claim 2 to promote growth.