ANTI-DLL3 CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Title:

ANTI-DLL3 CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2021/008610

Kind Code:

A1

Abstract:

Provided herein are anti-DLL3 chimeric antigen receptors (CARs), DLL3 binding proteins and uses of such CARs or DLL3 binding proteins in the treatment of DLL3 associated disorders, such as small cell lung cancer.

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Inventors:

ZHAO TAO (CN)
PENG YUANYUAN (CN)
TANG AN (CN)
WANG SUJUAN (CN)
YANG SHUAI (CN)
ZHANG WANG (CN)
WU SHU (CN)
HAO RUIDONG (CN)

Application Number:

PCT/CN2020/102717

Publication Date:

January 21, 2021

Filing Date:

July 17, 2020

Export Citation:

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Assignee:

NANJING LEGEND BIOTECH CO LTD (CN)

International Classes:

C07K19/00; A61P35/00; C07K16/30; C12N15/62

Domestic Patent References:

WO2016138038A1	2016-09-01
WO2016138038A1	2016-09-01
WO2019067805A1	2019-04-04
WO2019067805A1	2019-04-04
WO2018195348A1	2018-10-25
WO2018195348A1	2018-10-25
WO2018044866A1	2018-03-08
WO2019195408A1	2019-10-10
WO2019195408A1	2019-10-10
WO2019200007A1	2019-10-17
WO2019200007A1	2019-10-17
WO2018121712A1	2018-07-05

Foreign References:

CN105153315A

2015-12-16

Other References:

OWEN，D.H. ET AL.: "DLL3: an emerging target in small cell lung cancer", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 12, 18 June 2019 (2019-06-18), XP055693469, DOI: 20200923183843X
OWEN，D.H. ET AL.: "DLL3: an emerging target in small cell lung cancer", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 12, 18 June 2019 (2019-06-18), XP055693469, DOI: 20200925132149Y
See also references of EP 3999550A4

Attorney, Agent or Firm:

CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)

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