Title:
ANTI-HEPATITIS B VIRUS AGENT TARGETING HOST FACTOR DOCK11
Document Type and Number:
WIPO Patent Application WO/2023/090381
Kind Code:
A1
Abstract:
Disclosed is a new anti-HBV agent targeting host factor DOCK11. This anti-HBV agent contains, as an active ingredient, a substance which binds to DOCK11 and inhibits the function of DOCK11. In one embodiment, the anti-HBV according to the present invention contains, as an active ingredient, a DOCK11-binding peptide constituted by a specific amino acid sequence. The DOCK11-binding peptide may be a carrier molecule (for example, antibody, antibody fragment, or single-chain antibody binding to asialoglycoprotein receptor) for delivery into cells, a cell membrane permeation-promoting molecule, or in a form connected to a nuclear localization signal.
Inventors:
YANAGAWA HIROSHI (JP)
TABATA NORIKO (JP)
IDE MAYUKO (JP)
YONEMURA YUKO (JP)
ITO SATORU (JP)
KANEKO SHUICHI (JP)
HONDA MASAO (JP)
MURAI KAZUHISA (JP)
TABATA NORIKO (JP)
IDE MAYUKO (JP)
YONEMURA YUKO (JP)
ITO SATORU (JP)
KANEKO SHUICHI (JP)
HONDA MASAO (JP)
MURAI KAZUHISA (JP)
Application Number:
PCT/JP2022/042642
Publication Date:
May 25, 2023
Filing Date:
November 17, 2022
Export Citation:
Assignee:
PUROTECH BIO INC (JP)
International Classes:
A61K45/00; A61K38/10; A61K47/68; A61P1/16; A61P31/20; A61P43/00; C07K7/08; C07K16/28; C12N15/12; C12N15/13; C12N15/62
Domestic Patent References:
| WO2017082202A1 | 2017-05-18 |
Foreign References:
| KR20200101075A | 2020-08-27 |
Other References:
IDE MAYUKO, TABATA NORIKO, YONEMURA YUKO, SHIRASAKI TAKAYOSHI, MURAI KAZUHISA, WANG YING, ISHIDA ATSUYA, OKADA HIKARI, HONDA MASAO: "Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 298, no. 7, 1 July 2022 (2022-07-01), US , pages 102097, XP093067061, ISSN: 0021-9258, DOI: 10.1016/j.jbc.2022.102097
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
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