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Title:
ANTI-HEPATITIS C VIRUS NUCLEOSIDE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/184361
Kind Code:
A1
Abstract:
Disclosed are a compound represented by general formula (I), and pharmaceutically acceptable salt thereof, wherein A is O or C=CH2; B is a nucleoside base; Z is a connecting bond or CHR4; when W is a connecting bond or C(O), R is CH(R')C(Y)OR5; when W is CHC(Y)OR5, R is H; Y is O or S; R1 is H, D or CN; R2 is H, D, X, CN, CH=CH2, CCH or N3; each R3 independently is H, D, X, OH, N3, NR"2, or C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl unsubstituted or substituted by 1-5 halogens; each Ra independently is H, X, CN, R", NR"2, OR" or CO2R", or a 3- to 8-membered carbocyclic ring formed by Ra on two adjacent carbon atoms and the connected carbon atoms; each R" independently is D, C1-6 alkyl, C3-8 cycloalkyl, C1-6 acyl or C1-6 sulfonamido; alternatively the two R" and a connected nitrogen atom form a 4- to 8-membered ring. The compound represented by general formula (I) of the present invention has an excellent anti-hepatitis C virus effect.

Inventors:
ZHANG, Suoming (Room 206, Building No. 9 Lane 1011 Halei Road, Zhangjiang High Tech Par, Pudong New District Shanghai 3, 201203, CN)
Application Number:
CN2016/082001
Publication Date:
November 24, 2016
Filing Date:
May 13, 2016
Export Citation:
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Assignee:
SHANGHAI TANGRUN PHARMACEUTICALS, CO.LTD (Room 206, Building No.9 Lane 1011 Halei Road, Zhangjiang High Tech Par, Pudong New District Shanghai 3, 201203, CN)
International Classes:
C07H19/11; A61K31/706; A61K31/7068; A61K31/7072; A61K31/7076; A61P1/16; A61P31/14; C07H19/213; C07H19/23
Foreign References:
CN103421068A2013-12-04
CN1290707A2001-04-11
CA2749394A12010-07-15
Attorney, Agent or Firm:
SINO-ELITE INTELLECTUAL PROPERTY AGENCY (BEIJING) (B1105, TOP Office Center No.28 Xuanwumenwai Avenu, Xicheng District Beijing 2, 100052, CN)
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