Title:
ANTI-HER2 AFFIBODY, AND SWITCHABLE CHIMERIC ANTIGEN RECEPTOR USING SAME AS SWITCH MOLECULE
Document Type and Number:
WIPO Patent Application WO/2021/210939
Kind Code:
A1
Abstract:
The present invention relates to an anti-HER2 affibody, and a switch molecule comprising a cotinine-coupled anti-HER2 affibody. The anti-HER2 affibody of the present invention, when coupled with cotinine, reacts to positive cell lines in which HER2 is expressed if treated together with Cot-sCART, so as to induce the activity of immunocytes, and thus can be effectively used as a switch molecule for an sCART therapeutic agent.
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Inventors:
KIM KI HYUN (KR)
LEE HYUN-JONG (KR)
LEE JONG-SEO (KR)
LEE HYUN-JONG (KR)
LEE JONG-SEO (KR)
Application Number:
PCT/KR2021/004793
Publication Date:
October 21, 2021
Filing Date:
April 16, 2021
Export Citation:
Assignee:
ABCLON INC (KR)
International Classes:
C07K16/32; A61K31/40; A61K39/00; A61P37/02; C07K14/705; C07K16/44
Domestic Patent References:
| WO2018128485A1 | 2018-07-12 | |||
| WO2012096760A1 | 2012-07-19 | |||
| WO1995019374A1 | 1995-07-20 | |||
| WO2009080811A1 | 2009-07-02 | |||
| WO1988010649A | ||||
| WO1988007085A1 | 1988-09-22 | |||
| WO1988007086A1 | 1988-09-22 | |||
| WO1988009344A1 | 1988-12-01 |
Foreign References:
| KR20190121716A | 2019-10-28 | |||
| KR20180031727A | 2018-03-28 | |||
| US20150307564A1 | 2015-10-29 | |||
| KR20200047025A | 2020-05-07 |
Other References:
ABCLON INC.: "CAR-T's Core Competitive Edge is Antibody Development Technology", EQUITY RESEARCH, 22 April 2019 (2019-04-22), pages 1 - 16, XP009531397
GOLDSTEIN R ET AL., EXPERT REV ANTICANCER THER., 2013
YU F ET AL., MABS, 2014
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J. MOL. BIO., vol. 48, 1970, pages 443
PEARSONLIPMAN, METHODS IN MOL. BIOL., vol. 24, 1988, pages 307 - 31
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
CAO ET AL., ANGEW CHEM INT ED ENGL., vol. 55, no. 26, 20 June 2016 (2016-06-20), pages 7520 - 7524
"Remington's Pharmaceutical Sciences", 1995
"Cellular and Molecular Immunology", 1991, W. B. SAUNDERS CO., pages: 41 - 50
NISONOFF, A.: "Introduction to Molecular Immunology", 1984, SINAUER ASSOCIATES, INC., pages: 45 - 65
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH
ROSENBERG ET AL., NEW ENG. J. OF MED., vol. 319, 1988, pages 1676
GOLDSTEIN R ET AL., EXPERT REV ANTICANCER THER., 2013
YU F ET AL., MABS, 2014
SCHEIT: "Nucleotide Analogs", 1980, JOHN WILEY
UHLMANPEYMAN, CHEMICAL REVIEWS, vol. 90, 1990, pages 543 - 584
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J. MOL. BIO., vol. 48, 1970, pages 443
PEARSONLIPMAN, METHODS IN MOL. BIOL., vol. 24, 1988, pages 307 - 31
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC. ACIDS RES., vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP. APPL. BIOSCI., vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 31
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
CAO ET AL., ANGEW CHEM INT ED ENGL., vol. 55, no. 26, 20 June 2016 (2016-06-20), pages 7520 - 7524
"Remington's Pharmaceutical Sciences", 1995
"Cellular and Molecular Immunology", 1991, W. B. SAUNDERS CO., pages: 41 - 50
NISONOFF, A.: "Introduction to Molecular Immunology", 1984, SINAUER ASSOCIATES, INC., pages: 45 - 65
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1987, U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH
ROSENBERG ET AL., NEW ENG. J. OF MED., vol. 319, 1988, pages 1676
Attorney, Agent or Firm:
KONG, Byung Wook (KR)
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