Title:
ANTI-HER2 ANTIBODIES AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2016/205531
Kind Code:
A3
Abstract:
The invention provides anti-HER2 antibodies, including anti-HER2 antibodies of improved stability or affinity, and methods of using the same.
Inventors:
MATHIEU MARY (US)
DENNIS MARK (US)
DENNIS MARK (US)
Application Number:
PCT/US2016/037891
Publication Date:
February 09, 2017
Filing Date:
June 16, 2016
Export Citation:
Assignee:
GENENTECH INC (US)
HOFFMANN LA ROCHE (CH)
HOFFMANN LA ROCHE (CH)
International Classes:
C07K16/28; C07K16/32
Domestic Patent References:
| WO2003087131A2 | 2003-10-23 | |||
| WO2012143524A2 | 2012-10-26 | |||
| WO2012075581A1 | 2012-06-14 |
Foreign References:
| EP2482212A1 | 2012-08-01 |
Other References:
GERSTNER R B ET AL: "Sequence plasticity in the antigen-binding site of a therapeutic anti-HER 2 antibody", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 321, 1 January 2002 (2002-01-01), pages 851 - 862, XP002972421, ISSN: 0022-2836, DOI: 10.1016/S0022-2836(02)00677-0
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; March 2015 (2015-03-01), YANG YUEMEI ET AL: "Improving Trastuzumab's Stability Profile by Removing the Two Degradation Hotspots.", XP002761546, Database accession no. NLM25820189
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; March 2015 (2015-03-01), YANG YUEMEI ET AL: "Improving Trastuzumab's Stability Profile by Removing the Two Degradation Hotspots.", XP002761546, Database accession no. NLM25820189
Attorney, Agent or Firm:
ROPP, Traci H. et al. (US)
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