Title:
ANTI-HER2 ANTIBODY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2022/196697
Kind Code:
A1
Abstract:
Provided is a non-cardiotoxic antibody drug for breast cancer treatment. The present invention relates to an anti-HER2 antibody, or a functional fragment thereof, that binds to HER2 expressed in breast cancer cells and does not bind to HER2 expressed in myocardial cells, and a pharmaceutical composition containing the same.
Inventors:
IRIMURA TATSURO (JP)
FUJIHIRA HARUHIKO (JP)
NAGAI DENDA KAORI (JP)
SAITO MITSUE (JP)
HORIMOTO YOSHIYA (JP)
SASAKI RITSUKO (JP)
NOJI MIKI (JP)
SUZUKI KAZUHIRO (JP)
AKATSUKA JUN-ICHI (JP)
ONO KEN-ICHIRO (JP)
NISHIDA SHIYO (JP)
MATSUURA KATSUHISA (JP)
SHIMIZU TATSUYA (JP)
FUJIHIRA HARUHIKO (JP)
NAGAI DENDA KAORI (JP)
SAITO MITSUE (JP)
HORIMOTO YOSHIYA (JP)
SASAKI RITSUKO (JP)
NOJI MIKI (JP)
SUZUKI KAZUHIRO (JP)
AKATSUKA JUN-ICHI (JP)
ONO KEN-ICHIRO (JP)
NISHIDA SHIYO (JP)
MATSUURA KATSUHISA (JP)
SHIMIZU TATSUYA (JP)
Application Number:
PCT/JP2022/011687
Publication Date:
September 22, 2022
Filing Date:
March 15, 2022
Export Citation:
Assignee:
JUNTENDO EDUCATIONAL FOUND (JP)
MEDICAL & BIOLOGICAL LABORATORIES CO LTD (JP)
MEDICAL & BIOLOGICAL LABORATORIES CO LTD (JP)
International Classes:
C07K16/32; A61K38/05; A61K39/395; A61K47/68; A61P35/00; C12N15/13; C12P21/08
Foreign References:
| JP2009529010A | 2009-08-13 |
Other References:
DUARTE HENRIQUE, BALMAÑA MERITXELL, MEREITER STEFAN, OSÓRIO HUGO, GOMES JOANA, REIS CELSO: "Gastric Cancer Cell Glycosylation as a Modulator of the ErbB2 Oncogenic Receptor", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 18, no. 11, pages 2262, XP055967536, DOI: 10.3390/ijms18112262
KIT OLEG I., FRANTSIYANTS ELENA M., DJENKOVA LUBOV A., KATELNITSKAYA OKSANA V., SHIKHLYAROVA ALLA I., SAGAKYANTS ALEKSANDR B., VER: "Cardiotoxicity: a challenge for modern oncology", CARDIOMETRY, vol. 13814, no. 13, 1 November 2018 (2018-11-01), XP055967534, DOI: 10.12710/cardiometry.2018.13.814
KIT OLEG I., FRANTSIYANTS ELENA M., DJENKOVA LUBOV A., KATELNITSKAYA OKSANA V., SHIKHLYAROVA ALLA I., SAGAKYANTS ALEKSANDR B., VER: "Cardiotoxicity: a challenge for modern oncology", CARDIOMETRY, vol. 13814, no. 13, 1 November 2018 (2018-11-01), XP055967534, DOI: 10.12710/cardiometry.2018.13.814
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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