Title:
ANTI-HER2 IMMUNOTOXIN MOLECULE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/071987
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biological pharmacy, and in particular to an anti-HER2 immunotoxin molecule and a preparation method therefor and an application thereof. The anti-HER2 immunotoxin molecule comprises, from an amino end to a carboxyl end, a fusion polypeptide of an H-L1-PE structure or a PE-L1-H structure, wherein H is an anti-HER2 antibody or an antigen binding fragment thereof, L1 is a linker 1, and PE comprises part or all of a structural domain III of Pseudomonas exotoxin A. The immunotoxin molecule of the present invention can target cancer cells having HER2 positive expression in a high-specificity manner, thereby achieving efficient killing of cancer cells and inhibition of tumor growth.
Inventors:
XIAO JIANGUO (CN)
HUANG HAOMIN (CN)
ZHU ZHENPING (CN)
HUANG HAOMIN (CN)
ZHU ZHENPING (CN)
Application Number:
PCT/CN2022/127056
Publication Date:
May 04, 2023
Filing Date:
October 24, 2022
Export Citation:
Assignee:
SUNSHINE GUOJIAN PHARMACEUTICAL SHANGHAI CO LTD (CN)
International Classes:
A61K39/00; C07K19/00; A61P35/00; C12N15/62; C12N15/63
Domestic Patent References:
| WO2020050628A1 | 2020-03-12 |
Foreign References:
| CN106589131A | 2017-04-26 | |||
| CN113521015A | 2021-10-22 | |||
| RU2576232C1 | 2016-02-27 | |||
| US20190040151A1 | 2019-02-07 | |||
| CN112770769A | 2021-05-07 | |||
| CN103648525A | 2014-03-19 |
Other References:
MAHMOUDI REZA, DIANAT-MOGHADAM HASSAN, POOREBRAHIM MANSOUR, SIAPOUSH SAMANEH, POORTAHMASEBI VAHDAT, SALAHLOU REZA, RAHMATI MOHAMMA: "Recombinant immunotoxins development for HER2-based targeted cancer therapies", CANCER CELL INTERNATIONAL, vol. 21, no. 1, 1 December 2021 (2021-12-01), pages 470, XP093061110, DOI: 10.1186/s12935-021-02182-6
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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