Title:
ANTI-HIV ANTIBODY AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2020/090747
Kind Code:
A1
Abstract:
The present inventors conducted intensive studies on an antibody capable of resulting in HIV virus control over a long period of time at a high possibility in a group with sole administration thereof once or several times. As a result, the present inventors surprisingly found that, when SW-1C10 antibody, which was obtained by producing an antibody gene reported as 1C10 in silkworms, was solely administered only a few times, the number of viruses in the blood was suppressed to the detection limit or lower at an early stage in all of individuals administered therewith and, moreover, the viral RNA in the blood was maintained at the detection limit or lower for a long time of 12 weeks. In conventional antibody production methods using silkworms, the antibody yields roughly amount to several hundred g/cocoon or several μg/mg of cocoon. No attempt had been made hitherto to increase the productivity. The present inventors conducted intensive studies to find, from among a large number of anti-HIV antibodies, an antibody that can be produced at a higher yield by silkworms. As a result, the present inventors found that 1C10 antibody and 1D9 antibody, both being anti-HIV antibodies, were produced in silk threads of silkworms at higher yields than the conventional yields.
Inventors:
TOMITA MASAHIRO (JP)
SHIMIZU MAMORU (JP)
MATSUSHITA SHUZO (JP)
KUWATA TAKEO (JP)
MICHISHITA MASAHIRO (JP)
YASUTOMI YASUHIRO (JP)
OKAMURA TOMOTAKA (JP)
SHIMIZU MAMORU (JP)
MATSUSHITA SHUZO (JP)
KUWATA TAKEO (JP)
MICHISHITA MASAHIRO (JP)
YASUTOMI YASUHIRO (JP)
OKAMURA TOMOTAKA (JP)
Application Number:
PCT/JP2019/042184
Publication Date:
May 07, 2020
Filing Date:
October 28, 2019
Export Citation:
Assignee:
IMMUNO BIOLOGICAL LABORATORIES CO LTD (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
CURED INC (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
CURED INC (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
C07K16/10; A01K67/033; A61K39/395; A61P31/18; C12N15/13; C12N15/63; C12P21/08
Domestic Patent References:
| WO2009066702A1 | 2009-05-28 | |||
| WO2009066702A1 | 2009-05-28 | |||
| WO2017135452A1 | 2017-08-10 | |||
| WO2012120500A2 | 2012-09-13 |
Foreign References:
| JP2014012024A | 2014-01-23 | |||
| JP2014012024A | 2014-01-23 | |||
| US20080301823A1 | 2008-12-04 | |||
| JP2012182995A | 2012-09-27 | |||
| JP2004344123A | 2004-12-09 | |||
| JP2008125366A | 2008-06-05 | |||
| US20100081150A1 | 2010-04-01 | |||
| US20100304436A1 | 2010-12-02 | |||
| JP2016082962A | 2016-05-19 | |||
| US6602684B1 | 2003-08-05 | |||
| JP2018203114A | 2018-12-27 |
Other References:
ANONYMOUS: "the conclusion of the contract of the joint development with CURED CO., LTD.", 16 March 2018 (2018-03-16), JP, pages 1 - 2, XP009527840, Retrieved from the Internet [retrieved on 20191115]
KRISTEL PAOLA RAMIREZ VALDEZ, TAKEO KUWATA, YASUHIRO MARUTA, KAZUKI TANAKA, MUNTASIR ALAM, KAZUHISA YOSHIMURA, SHUZO MATSUSHITA: "Complementary and synergistic activities of anti-V3, CD 4bs and CD 4i antibodies derived from a single individual can cover a wide range of HIV-1 strains.", VIROLOGY, vol. 475, 1 January 2015 (2015-01-01), pages 187 - 203, XP055705633, ISSN: 0042-6822, DOI: 10.1016/j.virol.2014.11.011
YOSHIAKI NISHIMURA, RAJEEV GAUTAM, TAE-WOOK CHUN, REZA SADJADPOUR, KATHRYN E. FOULDS, MASASHI SHINGAI, FLORIAN KLEIN, ANNA GAZUMYA: "Early antibody therapy can induce long-lasting immunity to SHIV.", NATURE, vol. 543, 13 March 2017 (2017-03-13), pages 559 - 563, XP055705634, ISSN: 0028-0836, DOI: 10.1038/nature21435
RAJAT DESIKAN, RAJA RUBESH, DIXIT NARENDRA M.: "Early exposure to broadly neutralizing antibodies triggers a switch from progressive disease to lasting control of SHIV infection", 13 February 2019 (2019-02-13), XP055705638, Retrieved from the Internet [retrieved on 20191115], DOI: 10.1101/548727
MASASHI IIZUKA ET AL., FEBS JOURNAL, vol. 276, 2009, pages 5806 - 5820
MINORU TODA ET AL., MABS, vol. 7, no. 6, 2015, pages 1138 - 1150
DAN H. BAROUCH ET AL., NATURE, vol. 503, no. 7475, 2013, pages 224 - 228
KRISTEL PAOLA RAMIREZ VALDEZ ET AL., VIROLOGY, vol. 475, 2015, pages 187 - 203
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
HONEGGER, A ET AL., J. MOL. BIOL., vol. 309, 2001, pages 657 - 670
MACCALLUM ET AL., J MOL BIOL, vol. 262, no. 5, 1996, pages 732 - 745
J VIROL., vol. 86, 2012, pages 12039 - 52
TAMURA, T ET AL., NATURE BIOTECHNOLOGY, vol. 18, 2000, pages 81 - 84
NATURE BIOTECHNOLOGY, vol. 21, 2003, pages 52 - 56
GREG ALAZAR ET AL., PNAS, vol. 103, no. 11, 2006, pages 4005 - 4010
CANCER RES, vol. 67, no. 18, 2007, pages 8882 - 8890
YAKUJI NIPPO LIMITED: "Handbook of Pharmaceutical Excipients Fifth Edition", APHA PUBLICATIONS, article "Japanese Pharmaceutical Excipients"
REIMANN K.A. ET AL., J. VIROL., vol. 70, pages 6922 - 6928
NAT. BIOTECHNOL., vol. 18, 2000, pages 81 - 84
KANDA, Y. ET AL., J. BIOTECHNOL, vol. 130, no. 3, 2007, pages 300 - 10
RIPKA, J. ET AL., SOMAT CELL MOL GENET, vol. 12, no. 1, 1986, pages 51 - 62
SHIELDS, R. L. ET AL., J BIOL CHEM, vol. 277, no. 30, 2002, pages 26733 - 40
SCIENCE, vol. 329, 2010, pages 856 - 61
NATURE, vol. 477, 2011, pages 466 - 470
BIOTECHOL. BIOENG., vol. 106, 2010, pages 860 - 870
VIROLOGY., vol. 475, 2015, pages 187 - 203
SCIENCE, vol. 253, 1991, pages 71 - 4
J VIROL, vol. 86, 2012, pages 12039 - 52
AIDS, vol. 23, 2009, pages 897 - 906
MOL. CELLULAR PROTEOM., vol. 6, 2007, pages 1437 - 1445
KRISTEL PAOLA RAMIREZ VALDEZ, TAKEO KUWATA, YASUHIRO MARUTA, KAZUKI TANAKA, MUNTASIR ALAM, KAZUHISA YOSHIMURA, SHUZO MATSUSHITA: "Complementary and synergistic activities of anti-V3, CD 4bs and CD 4i antibodies derived from a single individual can cover a wide range of HIV-1 strains.", VIROLOGY, vol. 475, 1 January 2015 (2015-01-01), pages 187 - 203, XP055705633, ISSN: 0042-6822, DOI: 10.1016/j.virol.2014.11.011
YOSHIAKI NISHIMURA, RAJEEV GAUTAM, TAE-WOOK CHUN, REZA SADJADPOUR, KATHRYN E. FOULDS, MASASHI SHINGAI, FLORIAN KLEIN, ANNA GAZUMYA: "Early antibody therapy can induce long-lasting immunity to SHIV.", NATURE, vol. 543, 13 March 2017 (2017-03-13), pages 559 - 563, XP055705634, ISSN: 0028-0836, DOI: 10.1038/nature21435
RAJAT DESIKAN, RAJA RUBESH, DIXIT NARENDRA M.: "Early exposure to broadly neutralizing antibodies triggers a switch from progressive disease to lasting control of SHIV infection", 13 February 2019 (2019-02-13), XP055705638, Retrieved from the Internet
MASASHI IIZUKA ET AL., FEBS JOURNAL, vol. 276, 2009, pages 5806 - 5820
MINORU TODA ET AL., MABS, vol. 7, no. 6, 2015, pages 1138 - 1150
DAN H. BAROUCH ET AL., NATURE, vol. 503, no. 7475, 2013, pages 224 - 228
KRISTEL PAOLA RAMIREZ VALDEZ ET AL., VIROLOGY, vol. 475, 2015, pages 187 - 203
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
HONEGGER, A ET AL., J. MOL. BIOL., vol. 309, 2001, pages 657 - 670
MACCALLUM ET AL., J MOL BIOL, vol. 262, no. 5, 1996, pages 732 - 745
J VIROL., vol. 86, 2012, pages 12039 - 52
TAMURA, T ET AL., NATURE BIOTECHNOLOGY, vol. 18, 2000, pages 81 - 84
NATURE BIOTECHNOLOGY, vol. 21, 2003, pages 52 - 56
GREG ALAZAR ET AL., PNAS, vol. 103, no. 11, 2006, pages 4005 - 4010
CANCER RES, vol. 67, no. 18, 2007, pages 8882 - 8890
YAKUJI NIPPO LIMITED: "Handbook of Pharmaceutical Excipients Fifth Edition", APHA PUBLICATIONS, article "Japanese Pharmaceutical Excipients"
REIMANN K.A. ET AL., J. VIROL., vol. 70, pages 6922 - 6928
NAT. BIOTECHNOL., vol. 18, 2000, pages 81 - 84
KANDA, Y. ET AL., J. BIOTECHNOL, vol. 130, no. 3, 2007, pages 300 - 10
RIPKA, J. ET AL., SOMAT CELL MOL GENET, vol. 12, no. 1, 1986, pages 51 - 62
SHIELDS, R. L. ET AL., J BIOL CHEM, vol. 277, no. 30, 2002, pages 26733 - 40
SCIENCE, vol. 329, 2010, pages 856 - 61
NATURE, vol. 477, 2011, pages 466 - 470
BIOTECHOL. BIOENG., vol. 106, 2010, pages 860 - 870
VIROLOGY., vol. 475, 2015, pages 187 - 203
SCIENCE, vol. 253, 1991, pages 71 - 4
J VIROL, vol. 86, 2012, pages 12039 - 52
AIDS, vol. 23, 2009, pages 897 - 906
MOL. CELLULAR PROTEOM., vol. 6, 2007, pages 1437 - 1445
Attorney, Agent or Firm:
NAGOYA INTERNATIONAL PATENT FIRM et al. (JP)
Download PDF: