Title:
ANTI-HIV DRUG
Document Type and Number:
WIPO Patent Application WO/1990/009181
Kind Code:
A1
Abstract:
This invention provides an anti-HIV drug containing as an active ingredient a sulfated polysaccharide originating in sea cucumber and/or pharmaceutically acceptable salts thereof.
Inventors:
HOSHINO HIROO (JP)
Application Number:
PCT/JP1990/000159
Publication Date:
August 23, 1990
Filing Date:
February 09, 1990
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
KOTAI KASEI KK (JP)
KOTAI KASEI KK (JP)
International Classes:
C08B37/00; (IPC1-7): A61K31/725
Foreign References:
| JPS6348849B2 | 1988-09-30 | |||
| JPS6225126B2 | 1987-06-01 | |||
| JPH01165525A | 1989-06-29 | |||
| JPH01132526A | 1989-05-25 | |||
| JPS6413026A | 1989-01-17 | |||
| JPS6425724A | 1989-01-27 | |||
| JPS6452723A | 1989-02-28 | |||
| JPS63253026A | 1988-10-20 | |||
| JPS6345223A | 1988-02-26 | |||
| JPH01100127A | 1989-04-18 | |||
| JPH01275532A | 1989-11-06 | |||
| JPH01287031A | 1989-11-17 | |||
| JPH01313433A | 1989-12-18 | |||
| JPH02215A | 1990-01-05 | |||
| JPH01103601A | 1989-04-20 | |||
| JPH01199915A | 1989-08-11 | |||
| JPS6450821A | 1989-02-27 | |||
| JPH01230519A | 1989-09-14 | |||
| JPS63128001A | 1988-05-31 | |||
| EP0295956A2 | 1988-12-21 |
Other References:
CA112(3):16025d (Ucla Symp. Mol. Cell. Biol., New Ser., 100 (Mech. Action Ther. Appl. Biol. Cancer Immune Defic. Disord., 331-41 (1989) MITSUYA, HIROAKI; LOONEY, DAVID J.; KUNO, SACHIKO; UENO, RYUJI; WONG-STAAL, FLOSSIE; BRODER, SAMUEL: Abstract of "Inhibition of Virion Binding to CD4+Cells: Suppression of Human Immunodeficiency Viruses by Anionic Polysaccharides".)
CA112(1):258w (Experientia, 45 (10), 996-8 (1989) SUGAWARA, I.; ITOH, W.; KIMURA, S.; MORI S.; SHIMADA, K.: Abstract of "Further Characterization of Sulfated Homopolysaccharides as Anti-Hiv Agents".)
CA111(25):224861e (Chem. Pharm. Bull., 37 (9), 2410-12 (1989) HIRABAYASHI, K.; IWATA, S.; ITO, M.; SHIGETA, S.; NARUI, T.; MORI, T.; SHIBATA, S.: Abstract of "Inhibitory Effect of a Lichen Polysaccharide sulfate, GE-3-S, on the Replication of Human Immunodeficiency Virus (HIV) in Vitro".)
CA111(23):208773x (J. Acquired Immune Defic. Sundr., 2 (5), 441-7 (1989) TOCHIKURA, T. S.; NAKASHIMA, H.; YAMAMOTO, N.:Abstract of "Antiviral Agents with Activity Against Human Retroviruses".)
CA111(15):132308b (J. Immunol., 143(4), 1149-54 (1989) LEDERMAN, S.; GULICK, R.; CHESS, L.: Abstract of "Dextran sulfate and Heparin Interact with CD4 Molecules to Inhibit the Binding of Coat Protein (gp120) of HIV".)
CA111(9):72540p (Antiviral Res., 10(1-3), 107-15 (1988) NGAN, FUNG; CHANG, R. SHIHMAN; TABBA, HANI D.; SMITH, KEVIN M.: Abstract of "Isolation, Purification and Partial characterization of an Active Anti-HIV Compound from the Chinese Medicinal Herb Violayedoensis".)
CA110(23):205159v (Eur. J. Clin. Micrbiol. Infect. Dis., 8(2), 171-3 (1989) ITO, M.; BABA, M.; HIRABAYASHI, K.; Matsumoto, T.; SUZUKI, M.: SUZUKI, S.; SHIGETS, S.; DE CLERCQ, E.: Abstract of "Invitro Activity of Mannan Sulfate, a Novel Sulfated Polysaccharide, Against Human Immunodeficiency Virus Type 1 and other Enveloped Viruses".)
CA110(7):50810z (Antiviral Res., 9(6), 335-43 (1988) BABA, M.; NAKAJIMA, M.; SCHOLS, DOMINIQUE; PAUWELS, R.; BALZARINI. J.; DE CLERCQ, E.: Abstract of "Pentosan Polysulfate, a Sulfated Oligosaccharide, is a Potent and Selective Anti-HIV Agents in Vitro")
CA110(3):18171f (J. Infect. Dis., 158(5), 1084-7 (1988) BAGASRA, O.; LISCHNER, H. W.: Abstract of "Activity of Dextran Sulfate and other Polyanionic Polysaccharides Against Human Immodeficiency Virus".)
CA109(19):163104v (Biochem. Pharmacol., 37(15), 2887-91 (1988) YOSHIDA, O.; MAKASHIMA, H.; YOSHIDA, T.; KANEKO, Y.; YAMAMOTO, I.; MATSUZAKI, K.; URYU, T.; YAMAMOTO, N.: Abstract of "Sulfation of the Immunomodulating Polysaccharide Lentinan: a Novel Strategy for Antivirals to Human Immunodeficiency Virus (HIV)".)
CA109(19):162907x (Jpn. J. Exp. Med., 58(3), 145-51 (1988) MIZUMOTO, K.; SUGAWARA, I.; ITO, W.; KODAMA, T.; HAYAMI, M.; MORI, S.: Abstract of "Sulfated Homopolysaccharides with Immunodulating Activities are nore Potent Anti-HTLV-III Agents than Sulfated Hetero Polysaccharides".)
CA109(17):142064s (Proc. Natl. Acad. Sci. U.S.A., 85(16), 6132-6 (1988) BABA, M.; PAUWELS, R.; BALZARINI, J.; ARNOUT, J.; DESMYTER, J.; DE CLERCQ, E.: Abstract of "Mechanism of Inhibitory Effect of Dextran Sulfate and Hepain on Replication of Human Immunodeficiency Virus in Vitro")
CA109(11):89558c (Arch. Aids Res., 1(1), 45-56 (1987) YAMAMOTO, N.; NAKASHIMA, H.; YOSHIDA, O.; KANEKO, Y.; MATSUZAKI, K.; URYU, T.: Abstract of "Effect of the Sulfated Polysaccharides on HIV: a Novel Strategy of Chemical Modification for HIV Antivirals".)
CA108(11):87640d (Jpn. J. Cancer Res. (GANN), 78(11), 1164-8 (1987) NAKSHIMA, H.; YOSHIDA, O.; TOCHIKURA, T. S.; YOSHIDA, T.; MIMURA, T.; KIDO, Y.; MOTOKI, Y.; KANEKO, Y.; URYU, T.; YAMAMOTO, N.: Abstract of "Sulfation of Polysaccharides Generated and Selective Inhibitors of Human Immunodeficiency Virus Infection and Replication in Vitro".)
CA108(3):18337y (Antimicrob. Agents Chemother.. 31(10), 1524-8 (1987) NAKASHIMA, H.; KIDO, Y.; KOBAYASHI, N.; MOTOKI, Y.; NEUSHUL, M.; YAMAMOTO, N.: Abstract of "Purification and Characterization of an Avian Myeloblastosis and Human Immunodeficiency Virus Reverse Transcriptase Inhibitor, Sulfated Polysaccharides Extracted from Sea Algae".)
CA99(3):19901k (Yaoxue Xuebao, 18(3), 203-8 (1982) FAN, HUIZENG; CHEN, JUDI; LU, PEIHONG; HAO, XIAOGE; LE, HAITANG: Abstract of "Acidic Polysaccharides from Holothuria Leucospilota (Brandt)".)
CA94(8):52763m (Yao Hsueh Hsueh Pao, 15(5), 263-70 (1980) FAN, HUI-ZENG; CHEN, JU-DI; LIN, KE-ZHONG: Abstract of "Isolation of an Acidic Mucopolysaccharide from Stichopus Japonicus Selenka and some of its Physical and Chemical Properties".)
CA84(25):175525m (Chem. Pharm. Bull., 24(2), 275-84 (1976) KITAGAWA, ISAO; SUGAWARA, TAMIO; YOSIOKA, ITIRO: Abstract of "Saponin and Sapogenol. XV. Antifungal Glycosides from the Sea Cucumber Stichopus Japonicus Selenka. (2). Structures of Holotoxin A and Holotoxin B")
CA112(1):258w (Experientia, 45 (10), 996-8 (1989) SUGAWARA, I.; ITOH, W.; KIMURA, S.; MORI S.; SHIMADA, K.: Abstract of "Further Characterization of Sulfated Homopolysaccharides as Anti-Hiv Agents".)
CA111(25):224861e (Chem. Pharm. Bull., 37 (9), 2410-12 (1989) HIRABAYASHI, K.; IWATA, S.; ITO, M.; SHIGETA, S.; NARUI, T.; MORI, T.; SHIBATA, S.: Abstract of "Inhibitory Effect of a Lichen Polysaccharide sulfate, GE-3-S, on the Replication of Human Immunodeficiency Virus (HIV) in Vitro".)
CA111(23):208773x (J. Acquired Immune Defic. Sundr., 2 (5), 441-7 (1989) TOCHIKURA, T. S.; NAKASHIMA, H.; YAMAMOTO, N.:Abstract of "Antiviral Agents with Activity Against Human Retroviruses".)
CA111(15):132308b (J. Immunol., 143(4), 1149-54 (1989) LEDERMAN, S.; GULICK, R.; CHESS, L.: Abstract of "Dextran sulfate and Heparin Interact with CD4 Molecules to Inhibit the Binding of Coat Protein (gp120) of HIV".)
CA111(9):72540p (Antiviral Res., 10(1-3), 107-15 (1988) NGAN, FUNG; CHANG, R. SHIHMAN; TABBA, HANI D.; SMITH, KEVIN M.: Abstract of "Isolation, Purification and Partial characterization of an Active Anti-HIV Compound from the Chinese Medicinal Herb Violayedoensis".)
CA110(23):205159v (Eur. J. Clin. Micrbiol. Infect. Dis., 8(2), 171-3 (1989) ITO, M.; BABA, M.; HIRABAYASHI, K.; Matsumoto, T.; SUZUKI, M.: SUZUKI, S.; SHIGETS, S.; DE CLERCQ, E.: Abstract of "Invitro Activity of Mannan Sulfate, a Novel Sulfated Polysaccharide, Against Human Immunodeficiency Virus Type 1 and other Enveloped Viruses".)
CA110(7):50810z (Antiviral Res., 9(6), 335-43 (1988) BABA, M.; NAKAJIMA, M.; SCHOLS, DOMINIQUE; PAUWELS, R.; BALZARINI. J.; DE CLERCQ, E.: Abstract of "Pentosan Polysulfate, a Sulfated Oligosaccharide, is a Potent and Selective Anti-HIV Agents in Vitro")
CA110(3):18171f (J. Infect. Dis., 158(5), 1084-7 (1988) BAGASRA, O.; LISCHNER, H. W.: Abstract of "Activity of Dextran Sulfate and other Polyanionic Polysaccharides Against Human Immodeficiency Virus".)
CA109(19):163104v (Biochem. Pharmacol., 37(15), 2887-91 (1988) YOSHIDA, O.; MAKASHIMA, H.; YOSHIDA, T.; KANEKO, Y.; YAMAMOTO, I.; MATSUZAKI, K.; URYU, T.; YAMAMOTO, N.: Abstract of "Sulfation of the Immunomodulating Polysaccharide Lentinan: a Novel Strategy for Antivirals to Human Immunodeficiency Virus (HIV)".)
CA109(19):162907x (Jpn. J. Exp. Med., 58(3), 145-51 (1988) MIZUMOTO, K.; SUGAWARA, I.; ITO, W.; KODAMA, T.; HAYAMI, M.; MORI, S.: Abstract of "Sulfated Homopolysaccharides with Immunodulating Activities are nore Potent Anti-HTLV-III Agents than Sulfated Hetero Polysaccharides".)
CA109(17):142064s (Proc. Natl. Acad. Sci. U.S.A., 85(16), 6132-6 (1988) BABA, M.; PAUWELS, R.; BALZARINI, J.; ARNOUT, J.; DESMYTER, J.; DE CLERCQ, E.: Abstract of "Mechanism of Inhibitory Effect of Dextran Sulfate and Hepain on Replication of Human Immunodeficiency Virus in Vitro")
CA109(11):89558c (Arch. Aids Res., 1(1), 45-56 (1987) YAMAMOTO, N.; NAKASHIMA, H.; YOSHIDA, O.; KANEKO, Y.; MATSUZAKI, K.; URYU, T.: Abstract of "Effect of the Sulfated Polysaccharides on HIV: a Novel Strategy of Chemical Modification for HIV Antivirals".)
CA108(11):87640d (Jpn. J. Cancer Res. (GANN), 78(11), 1164-8 (1987) NAKSHIMA, H.; YOSHIDA, O.; TOCHIKURA, T. S.; YOSHIDA, T.; MIMURA, T.; KIDO, Y.; MOTOKI, Y.; KANEKO, Y.; URYU, T.; YAMAMOTO, N.: Abstract of "Sulfation of Polysaccharides Generated and Selective Inhibitors of Human Immunodeficiency Virus Infection and Replication in Vitro".)
CA108(3):18337y (Antimicrob. Agents Chemother.. 31(10), 1524-8 (1987) NAKASHIMA, H.; KIDO, Y.; KOBAYASHI, N.; MOTOKI, Y.; NEUSHUL, M.; YAMAMOTO, N.: Abstract of "Purification and Characterization of an Avian Myeloblastosis and Human Immunodeficiency Virus Reverse Transcriptase Inhibitor, Sulfated Polysaccharides Extracted from Sea Algae".)
CA99(3):19901k (Yaoxue Xuebao, 18(3), 203-8 (1982) FAN, HUIZENG; CHEN, JUDI; LU, PEIHONG; HAO, XIAOGE; LE, HAITANG: Abstract of "Acidic Polysaccharides from Holothuria Leucospilota (Brandt)".)
CA94(8):52763m (Yao Hsueh Hsueh Pao, 15(5), 263-70 (1980) FAN, HUI-ZENG; CHEN, JU-DI; LIN, KE-ZHONG: Abstract of "Isolation of an Acidic Mucopolysaccharide from Stichopus Japonicus Selenka and some of its Physical and Chemical Properties".)
CA84(25):175525m (Chem. Pharm. Bull., 24(2), 275-84 (1976) KITAGAWA, ISAO; SUGAWARA, TAMIO; YOSIOKA, ITIRO: Abstract of "Saponin and Sapogenol. XV. Antifungal Glycosides from the Sea Cucumber Stichopus Japonicus Selenka. (2). Structures of Holotoxin A and Holotoxin B")
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