Title:
ANTI-HLA-G CHIMERIC ANTIGEN RECEPTOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/182861
Kind Code:
A1
Abstract:
The present invention relates to: a chimeric antigen receptor comprising an antigen-binding site specifically binding to HLA-G, which is an immune checkpoint; immune cells into which the receptor is introduced; and use thereof. The immune cells can effectively remove cancer cells in which an immune checkpoint is expressed, such that even the activation of endogenous immune cells, which had been suppressed by immune checkpoints, can be expected, and thus can be effectively used as an immunotherapeutic method for various cancer diseases related to HLA-G.
Inventors:
KWON KI MUN (KR)
LEE BO EUN (KR)
BYUN SUNG HYUN (KR)
KIM CHAK HEE (KR)
YANG YOO HEE (KR)
KIM JI EUN (KR)
LEE BO EUN (KR)
BYUN SUNG HYUN (KR)
KIM CHAK HEE (KR)
YANG YOO HEE (KR)
KIM JI EUN (KR)
Application Number:
PCT/KR2023/003960
Publication Date:
September 28, 2023
Filing Date:
March 24, 2023
Export Citation:
Assignee:
HK INNO N CORP (KR)
International Classes:
C07K16/28; A61K39/00; A61P35/00
Foreign References:
| KR20210075117A | 2021-06-22 | |||
| KR20200097749A | 2020-08-19 | |||
| KR20210005080A | 2021-01-13 |
Other References:
DATABASE PROTEIN ANONYMOUS : "Sequence 54 from patent US 11111302", XP093095895, retrieved from NCBI
KRIJGSMAN DANIËLLE, ROELANDS JESSICA, HENDRICKX WOUTER, BEDOGNETTI DAVIDE, KUPPEN PETER J. K.: "HLA-G: A New Immune Checkpoint in Cancer?", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 12, pages 4528, XP093039278, DOI: 10.3390/ijms21124528
KRIJGSMAN DANIËLLE, ROELANDS JESSICA, HENDRICKX WOUTER, BEDOGNETTI DAVIDE, KUPPEN PETER J. K.: "HLA-G: A New Immune Checkpoint in Cancer?", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 12, pages 4528, XP093039278, DOI: 10.3390/ijms21124528
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
Download PDF: