Title:
ANTI-HS6ST2 ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/074049
Kind Code:
A1
Abstract:
Disclosed are: an antibody which binds to HS6ST2 protein; a pharmaceutical composition containing the antibody as an active ingredient; a method for diagnosing a cancer using the antibody; HS6ST2 protein to which a cytotoxic substance is bound; and a pharmaceutical composition containing the HS6ST2 protein as an active ingredient.
More Like This:
Inventors:
KAWAI SHIGETO (JP)
KIMURA NAOKI (JP)
KIMURA NAOKI (JP)
Application Number:
PCT/JP2009/071271
Publication Date:
July 01, 2010
Filing Date:
December 22, 2009
Export Citation:
Assignee:
FORERUNNER PHARMA RES CO LTD (JP)
KAWAI SHIGETO (JP)
KIMURA NAOKI (JP)
KAWAI SHIGETO (JP)
KIMURA NAOKI (JP)
International Classes:
C12N15/09; A61K39/395; A61P35/00; C07K16/40; C07K16/46; G01N33/574; C12P21/08
Domestic Patent References:
| WO2003104453A1 | 2003-12-18 | |||
| WO1994025585A1 | 1994-11-10 | |||
| WO1993012227A1 | 1993-06-24 | |||
| WO1992003918A1 | 1992-03-19 | |||
| WO1994002602A1 | 1994-02-03 | |||
| WO1994011523A2 | 1994-05-26 | |||
| WO1996002576A1 | 1996-02-01 | |||
| WO1993011161A1 | 1993-06-10 | |||
| WO1999054342A1 | 1999-10-28 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2002079255A1 | 2002-10-10 | |||
| WO2008093688A1 | 2008-08-07 |
Foreign References:
| EP0239400A2 | 1987-09-30 | |||
| EP0404097A2 | 1990-12-27 | |||
| JP2007020155A | 2007-01-25 |
Other References:
HABUCHI H. ET AL: "Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparansulphate 6-0-sulphotransferase-2 having different expression patterns and properties", BIOCHEM. J., vol. 371, 2003, pages 131 - 142, XP002683188, DOI: doi:10.1042/bj20021259
HABUCHI H. ET AL: "The occurrence of three isoforms of heparan sulfate 6-0- sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine", J. BIOL. CHEM., vol. 275, no. 4, 2000, pages 2859 - 2868, XP002148154, DOI: doi:10.1074/jbc.275.4.2859
BACKEN A.C. ET AL: "Heparan sulphate synthetic and editing enzymes in ovarian cancer", BR. J. CANCER, vol. 96, no. 10, 2007, pages 1544 - 1548, XP055037801, DOI: doi:10.1038/sj.bjc.6603747
GOICHIRO MIYAKE ET AL: "Heparan Ryusan-O- Ryusan Ten'i Koso-gun (HS2ST, HS6ST) no Hito Sodo Idenshi no Cloning to Gan Soshiki ni Okeru Hatsugen", CANCER SCIENCE, vol. 91, 1 September 2000 (2000-09-01), pages 145
See also references of EP 2388320A4
FASEB J., vol. 10, 1996, pages 598 - 614
J BIOL CHEM., vol. 279, 2004, pages 42732
"Functions of cell surface heparan sulfate proteoglycans", ANNU REV BIOCHEM., vol. 68, 1999, pages 729 - 777
"Heparan sulfate: growth control with a restricted sequence menu", J CLIN INVEST., vol. 108, 2001, pages 357 - 361
"Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor", J BIOL CHEM., vol. 269, 1994, pages 27149
"The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer", J CLIN INVEST., vol. 102, 1998, pages 1662
"Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro", J BIOL CHEM., vol. 273, 1998, pages 51
"Structural differences between heparan sulphates of proteoglycan involved in the formation of basement membranes in vivo by Lewis-lung-carcinoma-derived cloned cells with different metastatic potentials", BIOCHEM J., vol. 288, 1992, pages 215
"The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine", J BIOL CHEM., vol. 275, 2000, pages 2859
"Regulated diversity of heparan sulfate", J BIOL CHEM., vol. 273, 1998, pages 24979
"Stem domains of heparan sulfate 6-O.sulfotransferase are required for golgi localization, oligomer formation and enzyme activity", J CELL SCI., vol. 117, 2004, pages 3331
"Purification and characterization of heparan sulfate 6- sulfotransferase from the culture medium of Chinese hamster ovary cells", J BIOL CHEM., vol. 270, 1995, pages 4172
"Molecular characterization and expression of heparan-sulfate 6-sulfotransferase", J BIOL CHEM., vol. 273, 1998, pages 9208
"Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6.O-sulphotransferase-2 having different expression patterns and properties", BIOCHEM J., vol. 371, 2003, pages 131
"Regulation of heparan sulfate 6-O-sulfation by ?-secretase activity", J BIOL CHEM., 2007, pages 282
"Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity", J BIOL CHEM., vol. 278, 2003, pages 24371
"Affinity, kinetic, and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate", BIOCHEMISTRY, vol. 45, 2006, pages 5122
"Cell surface heparan sulfate proteoglycans", J BIOL CHEM., vol. 267, 1992, pages 9451
"Heparan sulfate proteoglycan as a plasma membrane carrier", TRENDS BIOCHEM SCI., vol. 28, 2003, pages 145
"Novel aspects of glypican glycobiology", CELL MOL LIFE SCI., vol. 61, 2004, pages 1016
"Internalization and trafficking of cell surface proteoglycans and proteoglycan-binding ligands", TRAFFIC., vol. 8, 2007, pages 389
"Glycosaminoglycans in human lung cancer", CANCER., vol. 48, 1981, pages 2016
"Heparan sulfate proteoglycan expression in human lung-cancer cells", INT J CANCER., vol. 74, 1997, pages 335
"Heterogeneity of heparan sulfates in human lung", AM J RESPIR CELL MOL BIOL., vol. 30, 2004, pages 166
SAMBROOK, J ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G., MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DE ST. GROTH, S. F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, I. S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER. G., MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
VANDAMME, A. M. ET AL., EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, vol. 18, 1979
CHOMCZYNSKI, P. ET AL., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FROHMAN, M.A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 8998 - 9002
BELYAVSKY, A. ET AL., NUCLEIC ACIDS RES., vol. 17, 1989, pages 2919 - 2932
J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
MIZUSHIMA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
FASEBJ., vol. 6, 1992, pages 2422 - 2427
BETTER ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
LEI, S. P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379
"Antibodies A Laboratory Manual.", 1988, COLD SPRING HARBOR LABORATORY
EBERT, K.M. ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
SATO, K. ET AL., CANCER RES, vol. 53, 1993, pages 851 - 856
CO, M.S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M., HORWITZ, A. H., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
SKERRA, A., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
LAMOYI, E., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 669
BIRD, R. E. ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
HOLLIGER P ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
PROC. NATL. ACAD. SCI. U.S.A, vol. 85, 1988, pages 5879 - 5883
CELLULAR & MOLECULAR IMMUNOLOGY, vol. 3, 2006, pages 439 - 443
HUDSON ET AL., J IMMUNOL. METHODS, vol. 231, 1999, pages 177 - 189
PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
CO, M. S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M., HORWITZ, A. H., METHODS ENZYMOL., vol. 178, 1989, pages 476 - 496
PLUCKTHUN, A., SKERRA, A., METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
LAMOYI, E., METHODS ENZYMOL., vol. 121, 1986, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 669
BIRD, R. E., WALKER, B. W., TRENDS BIOTECHNOL., vol. 9, 1991, pages 132 - 137
LANGONE J.J. ET AL., METHODS IN ENZYMOLOGY, vol. 93, 1983, pages 307 - 308
NATURE MEDICINE, vol. 2, 1996, pages 350 - 353
FULTON R.J. ET AL., J. BIOL. CHEM., vol. 261, 1986, pages 5314 - 5319
SIVAM G. ET AL., CANCER RES., vol. 47, 1987, pages 3169 - 3173
CUMBER A.J. ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
WAWRZYNCZAK E.J. ET AL., CANCER RES., vol. 50, 1990, pages 7519 - 7562
GHEEITE V. ET AL., J. IMMUNOL. METHODS, vol. 142, 1991, pages 223 - 230
THORPE P.E. ET AL., CANCER RES., vol. 47, 1987, pages 5924 - 5931
WAWRZYNCZAK E.J. ET AL., BR. J. CANCER, vol. 66, 1992, pages 361 - 366
BOLOGNESI A. ET AL., CLIN. EXP. IMMUNOL., vol. 89, 1992, pages 341 - 346
STIRPE F., BARBIERI L., FEBS LETTER, vol. 195, 1986, pages 1 - 8
STIRPE F., BARBIERI L., FEBS LETTER, vol. 195, 1986, pages 1 - 8
STIRPE, vol. 1-8, 1986, pages 1
STIRPE F., BARBIERI L, FEBS 1 LETTER, vol. 195, 1986, pages 1 - 8
CASELLAS P. ET AL., EUR. J. BIOCHEM., vol. 176, 1988, pages 581 - 588
"Current protocols in Immunology", 1993, JOHN WILEY & SONS, INC.
HASHIMOTO-GOTOH, T. ET AL., GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ, SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER W, FRITZ HJ, METHODS. ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA, PROC NATL ACAD SCI USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
MARK, D. F. ET AL., PROC. NAT1. ACAD. SCI. USA, vol. 81, 1984, pages 5662 - 5666
ZOLLER, M. J., SMITH, M., NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487 - 6500
WANG, A. ET AL., SCIENCE, vol. 224, pages 1431 - 1433
DALBADIE-MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 6413
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
ACTA ONCOL., vol. 32, 1993, pages 825 - 830
"Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-0-sulphotransferase-2 having different expression patterns and properties", BIOCHEM J., vol. 371, 2003, pages 131
BIOCHEM J., vol. 371, 2003, pages 131
"Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer", CANCER RES, vol. 62, 2002, pages 5210
"Serum and urinary concentrations of heparan sulfate in patients with diabetic nephropathy", KIDNEY INT, vol. 56, 1999, pages 650
"Isolation and characterization of glycosaminoglycans in human plasma", J CLIN INVEST, vol. 76, 1985, pages 1984
HABUCHI H. ET AL: "The occurrence of three isoforms of heparan sulfate 6-0- sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine", J. BIOL. CHEM., vol. 275, no. 4, 2000, pages 2859 - 2868, XP002148154, DOI: doi:10.1074/jbc.275.4.2859
BACKEN A.C. ET AL: "Heparan sulphate synthetic and editing enzymes in ovarian cancer", BR. J. CANCER, vol. 96, no. 10, 2007, pages 1544 - 1548, XP055037801, DOI: doi:10.1038/sj.bjc.6603747
GOICHIRO MIYAKE ET AL: "Heparan Ryusan-O- Ryusan Ten'i Koso-gun (HS2ST, HS6ST) no Hito Sodo Idenshi no Cloning to Gan Soshiki ni Okeru Hatsugen", CANCER SCIENCE, vol. 91, 1 September 2000 (2000-09-01), pages 145
See also references of EP 2388320A4
FASEB J., vol. 10, 1996, pages 598 - 614
J BIOL CHEM., vol. 279, 2004, pages 42732
"Functions of cell surface heparan sulfate proteoglycans", ANNU REV BIOCHEM., vol. 68, 1999, pages 729 - 777
"Heparan sulfate: growth control with a restricted sequence menu", J CLIN INVEST., vol. 108, 2001, pages 357 - 361
"Heparan sulfate is essential to amphiregulin-induced mitogenic signaling by the epidermal growth factor receptor", J BIOL CHEM., vol. 269, 1994, pages 27149
"The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer", J CLIN INVEST., vol. 102, 1998, pages 1662
"Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro", J BIOL CHEM., vol. 273, 1998, pages 51
"Structural differences between heparan sulphates of proteoglycan involved in the formation of basement membranes in vivo by Lewis-lung-carcinoma-derived cloned cells with different metastatic potentials", BIOCHEM J., vol. 288, 1992, pages 215
"The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine", J BIOL CHEM., vol. 275, 2000, pages 2859
"Regulated diversity of heparan sulfate", J BIOL CHEM., vol. 273, 1998, pages 24979
"Stem domains of heparan sulfate 6-O.sulfotransferase are required for golgi localization, oligomer formation and enzyme activity", J CELL SCI., vol. 117, 2004, pages 3331
"Purification and characterization of heparan sulfate 6- sulfotransferase from the culture medium of Chinese hamster ovary cells", J BIOL CHEM., vol. 270, 1995, pages 4172
"Molecular characterization and expression of heparan-sulfate 6-sulfotransferase", J BIOL CHEM., vol. 273, 1998, pages 9208
"Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6.O-sulphotransferase-2 having different expression patterns and properties", BIOCHEM J., vol. 371, 2003, pages 131
"Regulation of heparan sulfate 6-O-sulfation by ?-secretase activity", J BIOL CHEM., 2007, pages 282
"Oligosaccharide library-based assessment of heparan sulfate 6-O-sulfotransferase substrate specificity", J BIOL CHEM., vol. 278, 2003, pages 24371
"Affinity, kinetic, and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate", BIOCHEMISTRY, vol. 45, 2006, pages 5122
"Cell surface heparan sulfate proteoglycans", J BIOL CHEM., vol. 267, 1992, pages 9451
"Heparan sulfate proteoglycan as a plasma membrane carrier", TRENDS BIOCHEM SCI., vol. 28, 2003, pages 145
"Novel aspects of glypican glycobiology", CELL MOL LIFE SCI., vol. 61, 2004, pages 1016
"Internalization and trafficking of cell surface proteoglycans and proteoglycan-binding ligands", TRAFFIC., vol. 8, 2007, pages 389
"Glycosaminoglycans in human lung cancer", CANCER., vol. 48, 1981, pages 2016
"Heparan sulfate proteoglycan expression in human lung-cancer cells", INT J CANCER., vol. 74, 1997, pages 335
"Heterogeneity of heparan sulfates in human lung", AM J RESPIR CELL MOL BIOL., vol. 30, 2004, pages 166
SAMBROOK, J ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G., MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DE ST. GROTH, S. F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, I. S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER. G., MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
VANDAMME, A. M. ET AL., EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, vol. 18, 1979
CHOMCZYNSKI, P. ET AL., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FROHMAN, M.A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 8998 - 9002
BELYAVSKY, A. ET AL., NUCLEIC ACIDS RES., vol. 17, 1989, pages 2919 - 2932
J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
MIZUSHIMA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
FASEBJ., vol. 6, 1992, pages 2422 - 2427
BETTER ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
LEI, S. P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379
"Antibodies A Laboratory Manual.", 1988, COLD SPRING HARBOR LABORATORY
EBERT, K.M. ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
SATO, K. ET AL., CANCER RES, vol. 53, 1993, pages 851 - 856
CO, M.S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M., HORWITZ, A. H., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
SKERRA, A., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
LAMOYI, E., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 669
BIRD, R. E. ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
HOLLIGER P ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
PROC. NATL. ACAD. SCI. U.S.A, vol. 85, 1988, pages 5879 - 5883
CELLULAR & MOLECULAR IMMUNOLOGY, vol. 3, 2006, pages 439 - 443
HUDSON ET AL., J IMMUNOL. METHODS, vol. 231, 1999, pages 177 - 189
PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
CO, M. S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M., HORWITZ, A. H., METHODS ENZYMOL., vol. 178, 1989, pages 476 - 496
PLUCKTHUN, A., SKERRA, A., METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
LAMOYI, E., METHODS ENZYMOL., vol. 121, 1986, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 669
BIRD, R. E., WALKER, B. W., TRENDS BIOTECHNOL., vol. 9, 1991, pages 132 - 137
LANGONE J.J. ET AL., METHODS IN ENZYMOLOGY, vol. 93, 1983, pages 307 - 308
NATURE MEDICINE, vol. 2, 1996, pages 350 - 353
FULTON R.J. ET AL., J. BIOL. CHEM., vol. 261, 1986, pages 5314 - 5319
SIVAM G. ET AL., CANCER RES., vol. 47, 1987, pages 3169 - 3173
CUMBER A.J. ET AL., J. IMMUNOL. METHODS, vol. 135, 1990, pages 15 - 24
WAWRZYNCZAK E.J. ET AL., CANCER RES., vol. 50, 1990, pages 7519 - 7562
GHEEITE V. ET AL., J. IMMUNOL. METHODS, vol. 142, 1991, pages 223 - 230
THORPE P.E. ET AL., CANCER RES., vol. 47, 1987, pages 5924 - 5931
WAWRZYNCZAK E.J. ET AL., BR. J. CANCER, vol. 66, 1992, pages 361 - 366
BOLOGNESI A. ET AL., CLIN. EXP. IMMUNOL., vol. 89, 1992, pages 341 - 346
STIRPE F., BARBIERI L., FEBS LETTER, vol. 195, 1986, pages 1 - 8
STIRPE F., BARBIERI L., FEBS LETTER, vol. 195, 1986, pages 1 - 8
STIRPE, vol. 1-8, 1986, pages 1
STIRPE F., BARBIERI L, FEBS 1 LETTER, vol. 195, 1986, pages 1 - 8
CASELLAS P. ET AL., EUR. J. BIOCHEM., vol. 176, 1988, pages 581 - 588
"Current protocols in Immunology", 1993, JOHN WILEY & SONS, INC.
HASHIMOTO-GOTOH, T. ET AL., GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ, SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER W, FRITZ HJ, METHODS. ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA, PROC NATL ACAD SCI USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
MARK, D. F. ET AL., PROC. NAT1. ACAD. SCI. USA, vol. 81, 1984, pages 5662 - 5666
ZOLLER, M. J., SMITH, M., NUCLEIC ACIDS RESEARCH, vol. 10, 1982, pages 6487 - 6500
WANG, A. ET AL., SCIENCE, vol. 224, pages 1431 - 1433
DALBADIE-MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 6413
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
ACTA ONCOL., vol. 32, 1993, pages 825 - 830
"Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-0-sulphotransferase-2 having different expression patterns and properties", BIOCHEM J., vol. 371, 2003, pages 131
BIOCHEM J., vol. 371, 2003, pages 131
"Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer", CANCER RES, vol. 62, 2002, pages 5210
"Serum and urinary concentrations of heparan sulfate in patients with diabetic nephropathy", KIDNEY INT, vol. 56, 1999, pages 650
"Isolation and characterization of glycosaminoglycans in human plasma", J CLIN INVEST, vol. 76, 1985, pages 1984
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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