Title:
ANTI-HUMAN IL6 MONOCLONAL ANTIBODIES, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/109947
Kind Code:
A1
Abstract:
The present invention provide anti-human IL6 monoclonal antibodies, amino acid sequences of the variable region of the heavy chain and of the variable region of the light chain thereof, and encoding nucleotide sequences thereof. The present invention also provides a method for preparing the anti-human IL6 monoclonal antibodies and use of the anti-human IL6 monoclonal antibodies in the preparation of an antitumor drug. The present anti-human IL6 monoclonal antibodies can inhibit cell proliferation by blocking an IL6 signal pathway, thereby achieving the purpose of tumor Immunotherapy.
Inventors:
YIN LIUSONG (CN)
LIN FENG (CN)
WANG LEI (CN)
XU YUNYUN (CN)
DING LI (CN)
LIN FENG (CN)
WANG LEI (CN)
XU YUNYUN (CN)
DING LI (CN)
Application Number:
PCT/CN2018/119353
Publication Date:
June 13, 2019
Filing Date:
December 05, 2018
Export Citation:
Assignee:
NANJINGJINSIRUI SCIENCE & TECH BIOLOGY CORP (CN)
International Classes:
C07K16/24; A61K39/395; A61P35/00; C12N15/13
Foreign References:
| CN102083860A | 2011-06-01 | |||
| CN107249631A | 2017-10-13 | |||
| CN1694894A | 2005-11-09 | |||
| CN102245207A | 2011-11-16 |
Other References:
JANEWAY ET AL.: "Immunology: The Immune System in Health and Disease", 2005, GARLAND SCIENCE
YOSHIMOTO ET AL., IMMUNOTHERAPY, vol. 5, 2009, pages 825 - 844
STEWART ET AL., CANCER METASTASIS REV., vol. 30, 2011, pages 125 - 140
INT. J. MOL. SCI., vol. 16, 2015, pages 1691 - 1710
See also references of EP 3722311A4
YOSHIMOTO ET AL., IMMUNOTHERAPY, vol. 5, 2009, pages 825 - 844
STEWART ET AL., CANCER METASTASIS REV., vol. 30, 2011, pages 125 - 140
INT. J. MOL. SCI., vol. 16, 2015, pages 1691 - 1710
See also references of EP 3722311A4
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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