Title:
ANTI-HUMAN TRANSFERRIN RECEPTOR ANTIBODY PERMEATING BLOOD-BRAIN BARRIER
Document Type and Number:
WIPO Patent Application WO/2016/208695
Kind Code:
A1
Abstract:
Disclosed is a means that can be used for modifying a biologically or pharmacologically active substance from a form incapable of permeating the blood-brain barrier to a form capable of permeating the blood-brain barrier. Also disclosed is a modified substance obtained by using the means. The means is anti-human transferrin receptor antibody and the modified substance is a molecular conjugate of a biologically active protein or a pharmacologically active low-molecular-weight compound and anti-human transferrin receptor antibody.
Inventors:
SONODA HIROYUKI (JP)
TAKAHASHI KENICHI (JP)
TAKAHASHI KENICHI (JP)
Application Number:
PCT/JP2016/068738
Publication Date:
December 29, 2016
Filing Date:
June 24, 2016
Export Citation:
Assignee:
JAPAN CHEM RES (JP)
International Classes:
C12N15/09; A61K39/395; A61K45/00; A61P9/10; A61P21/02; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P31/04; A61P31/12; A61P35/00; C07K14/475; C07K16/18; C07K16/28; C07K16/46; C07K19/00; C12N5/10; C12N9/10; C12N9/16; C12N9/24; C12N9/64; C12N15/113; C12P21/08
Domestic Patent References:
| WO2013177062A2 | 2013-11-28 | |||
| WO2015009961A1 | 2015-01-22 | |||
| WO2015098989A1 | 2015-07-02 | |||
| WO2012075037A1 | 2012-06-07 | |||
| WO2014189973A2 | 2014-11-27 |
Foreign References:
| JPH05500944A | 1993-02-25 | |||
| JP2014514313A | 2014-06-19 |
Other References:
SADE H. ET AL.: "A Human Blood-Brain Barrier Transcytosis Assay Reveals Antibody Transcytosis Influenced by pH-Dependent Receptor Binding.", PLOS ONE., vol. 9, no. 4, 2014, pages e96340, XP055221844, Retrieved from the Internet [retrieved on 20160818]
FRIDEN PM. ET AL.: "Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor.", J PHARMACOL EXP THER., vol. 278, no. 3, 1996, pages 1491 - 1498, XP000984836
PARDRIDGE WM.: "Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody.", EXPERT OPIN DRUG DELIV., vol. 12, no. 2, February 2015 (2015-02-01), pages 207 - 222, XP009183494
See also references of EP 3315606A4
FRIDEN PM. ET AL.: "Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor.", J PHARMACOL EXP THER., vol. 278, no. 3, 1996, pages 1491 - 1498, XP000984836
PARDRIDGE WM.: "Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody.", EXPERT OPIN DRUG DELIV., vol. 12, no. 2, February 2015 (2015-02-01), pages 207 - 222, XP009183494
See also references of EP 3315606A4
Attorney, Agent or Firm:
HAYASAKA, Takumi (JP)
Takumi Hayasaka (JP)
Takumi Hayasaka (JP)
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