Title:
ANTI-IL-13/IL-17 BISPECIFIC ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/127405
Kind Code:
A3
Abstract:
The invention provides anti-IL-13/IL-17 bispecific antibodies, in particular, anti-IL13/IL17 AA, AF and FF antibodies and methods of using the same, including without limitation, methods of using the anti-IL-13/IL-17 bispecific antibodies for treating moderate to severe asthma and/or eosinophilic asthma.
Inventors:
WU LAWREN (US)
ARRON JOSEPH R (US)
DILLON MICHAEL (US)
CHOY DAVID F (US)
SOHN SUE (US)
SPIESS CHRISTOPH (US)
SHATZ WHITNEY (US)
ARRON JOSEPH R (US)
DILLON MICHAEL (US)
CHOY DAVID F (US)
SOHN SUE (US)
SPIESS CHRISTOPH (US)
SHATZ WHITNEY (US)
Application Number:
PCT/US2015/017168
Publication Date:
October 15, 2015
Filing Date:
February 23, 2015
Export Citation:
Assignee:
GENENTECH INC (US)
HOFFMANN LA ROCHE (CH)
HOFFMANN LA ROCHE (CH)
International Classes:
A61K39/395; A61P11/06; C07K16/24
Domestic Patent References:
| WO2013102042A2 | 2013-07-04 | |||
| WO2009136286A2 | 2009-11-12 | |||
| WO2012083132A2 | 2012-06-21 | |||
| WO2005062967A2 | 2005-07-14 | |||
| WO2014165771A2 | 2014-10-09 |
Other References:
C. SPIESS ET AL: "Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 37, 13 September 2013 (2013-09-13), pages 26583 - 26593, XP055116683, ISSN: 0021-9258, DOI: 10.1074/jbc.M113.480483
LUCA GALLELLI ET AL: "Update on Anticytokine Treatment for Asthma", BIOMED RESEARCH INTERNATIONAL, vol. 182, no. 3, 1 January 2013 (2013-01-01), pages 1577 - 10, XP055186327, ISSN: 2314-6133, DOI: 10.4049/jimmunol.1101980
HUANG F ET AL: "Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 121, no. 6, 1 June 2008 (2008-06-01), pages 1415 - 1421.e3, XP022760251, ISSN: 0091-6749, [retrieved on 20080606], DOI: 10.1016/J.JACI.2008.04.016
LUCA GALLELLI ET AL: "Update on Anticytokine Treatment for Asthma", BIOMED RESEARCH INTERNATIONAL, vol. 182, no. 3, 1 January 2013 (2013-01-01), pages 1577 - 10, XP055186327, ISSN: 2314-6133, DOI: 10.4049/jimmunol.1101980
HUANG F ET AL: "Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 121, no. 6, 1 June 2008 (2008-06-01), pages 1415 - 1421.e3, XP022760251, ISSN: 0091-6749, [retrieved on 20080606], DOI: 10.1016/J.JACI.2008.04.016
Attorney, Agent or Firm:
CHANG, Y. Elaine et al. (Inc.Mail Stop 4, South San Francisco California, US)
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