Title:
ANTI-INFLAMMATORY AGENT
Document Type and Number:
WIPO Patent Application WO/2003/082855
Kind Code:
A1
Abstract:
(IIa) (I) (IIIa) [In the formula (I), R1 and R3 are the same or different and each represents hydrogen, -NR4R5 (wherein R4 and R5 are the same or different and each represents hydrogen, (un)substituted lower alkyl, etc.), etc.; and R2 represents a group represented by the formula (IIa) (wherein R7a represents -NR8R9, etc.), a group represented by the formula (IIIa) (wherein R10 represents (un)substituted lower alkyl, etc.), etc.] The anti-inflammatory agent contains as an active ingredient a 5-cyanopyrimidine derivative represented by the formula (I), a quaternary ammonium salt thereof, or a pharmacologically acceptable salt of either. Also provided are a 5-cyanopyrimidine derivative represented by the formula (I) wherein R3 is, e.g., hydrogen and a pharmacologically acceptable salt or other derivative thereof.
Inventors:
MACHII DAISUKE (JP)
YAMAURA YOSUKE (JP)
ARAI HITOSHI (JP)
YANAGAWA KOJI (JP)
OHSHIMA ETSUO (JP)
KAWANABE ARI (JP)
IWASE MIHO (JP)
KOBAYASHI KATSUYA (GB)
SATO TAKASHI (JP)
MIKI ICHIRO (JP)
YAMAURA YOSUKE (JP)
ARAI HITOSHI (JP)
YANAGAWA KOJI (JP)
OHSHIMA ETSUO (JP)
KAWANABE ARI (JP)
IWASE MIHO (JP)
KOBAYASHI KATSUYA (GB)
SATO TAKASHI (JP)
MIKI ICHIRO (JP)
Application Number:
PCT/JP2003/004009
Publication Date:
October 09, 2003
Filing Date:
March 28, 2003
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
MACHII DAISUKE (JP)
YAMAURA YOSUKE (JP)
ARAI HITOSHI (JP)
YANAGAWA KOJI (JP)
OHSHIMA ETSUO (JP)
KAWANABE ARI (JP)
IWASE MIHO (JP)
KOBAYASHI KATSUYA (GB)
SATO TAKASHI (JP)
MIKI ICHIRO (JP)
MACHII DAISUKE (JP)
YAMAURA YOSUKE (JP)
ARAI HITOSHI (JP)
YANAGAWA KOJI (JP)
OHSHIMA ETSUO (JP)
KAWANABE ARI (JP)
IWASE MIHO (JP)
KOBAYASHI KATSUYA (GB)
SATO TAKASHI (JP)
MIKI ICHIRO (JP)
International Classes:
A61K31/506; A61P29/00; A61P37/08; A61P43/00; C07D401/12; (IPC1-7): C07D401/12; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61P29/00; A61P37/08; A61P43/00; C07D239/42; C07D401/04; C07D401/14; C07D403/04; C07D403/12; C07D405/12; C07D413/04
Domestic Patent References:
| WO2001046200A1 | 2001-06-28 | |||
| WO2000059498A1 | 2000-10-12 |
Other References:
EL-SAYED A.M. BRADAWEY ET AL.: "Nonsteroidal antiinflammatory agents. Part 1: Antiinflammatory, analgesic and antipyretic activity of some new 1-(pyrimidin-2-yl)-3-pyrazolin-5-ones and 2-(pyrimidin-2-yl)-1,2,4,5,6,7-hexahydro-3H-indazol-3-ones", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 5, 1998, pages 349 - 361, XP002962153
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